Browsing Chemistry by Title
Now showing items 671-690 of 839
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Stability and Aggregation Studies of Immature Superoxide Dismutase
(University of Waterloo, 2015-08-27)Amyotrophic Lateral Sclerosis is a devastating neurological disease with no known cure. In 1993, a genetic link was established between ALS and mutant forms of Cu, Zn-superoxide dismutase (SOD1), an antioxidant enzyme ... -
Stability and Strain in Hisactophilin and Mechanism of the Myristoyl Switch
(University of Waterloo, 2019-05-23)Hisactophilin is a myristoylated, histidine-rich, pH-dependent actin- and membrane-binding protein. In response to cellular changes in pH, this β-trefoil protein reversibly switches between cytosolic and membrane- bound ... -
Stabilizing DNA G-quadruplexes by thallium(I) and its application for thallium detection
(University of Waterloo, 2015-08-21)Heavy metals such as thallium are dangerous to living organisms and the environment. They are toxic and harmful. The threat of pollution from these metals is ever growing due to increased mining around the world. Thallium ... -
Starch Nanoparticles for Targeted Anti-Cancer Drug Delivery
(University of Waterloo, 2015-08-24)In the field of anti-cancer drug delivery, nanoparticles have become an active topic of research. Nanoparticles made of biodegradable materials such as polylactic acid, proteins, and polysaccharides have been reported for ... -
Starch nanoparticles: modifications, toxicity, and drug loading
(University of Waterloo, 2015-04-30)Nanoparticles as drug delivery vehicles have been well tested and transferred into clinical practice in the past few decades. The success of most nanocarriers is attributed to their biocompatibility, controlled release and ... -
Starch-based Polymers as Flocculants of Oil Sands Mature Fine Tailings and for Extraction of Bitumen from Oil Sands
(University of Waterloo, 2020-09-25)Mature fine tailings (MFT) generated by oil sands extraction operations in Alberta pose significant environmental challenges. Polymeric flocculants are often needed to accelerate the consolidation and dewatering of MFT. A ... -
Static and Dynamic Theoretical Studies on Vibronic Model Based Potential Energy Surface(s): Locating Transition Structures and Fundamental Investigations in Time-resolved Spectroscopy
(University of Waterloo, 2017-10-05)Construction and exploration of Potential Energy Surfaces (PES) is central to the study of many interesting chemical phenomena, such as computing the rate of a chemical reaction or elucidating structure of a complex ... -
Stille Coupling of α-Acyloxybenzylstannanes with Acid Chlorides
(University of Waterloo, 2016-08-19)Two widely-accepted models (open- and cyclic- transmetalation) are applied to explain the stereochemical outcome of the Stille coupling with organotin compounds containing an sp3 chiral center. However, it is still not ... -
Stille Coupling of α-Alkoxybenzylstannanes: Optimization Study and Stereochemical Outcome
(University of Waterloo, 2011-08-24)In order to make the stereospecific palladium-catalyzed cross-coupling of α-alkoxybenzyl-stannanes a useful synthetic methodology, optimization was undertaken to improve the coupling yields between these stannanes and ... -
Stille Coupling Reactions Involving α-Alkoxybenzylstannanes
(University of Waterloo, 2007-12-20)The Stille reaction has established itself as one of the two most general and most selective palladium-catalyzed cross-coupling reactions, along with the Suzuki cross-coupling of organoboron compounds. The Stille coupling ... -
Stimuli-responsive releasing of gold nanoparticles and liposomes from aptamer-functionalized hydrogels
(Institute of Physics, 2011-11-21)Controlled release of therapeutic agents is important for improving drug efficacy and reducing toxicity. Recently, hydrogels have been used for controlled release applications. While the majority of the previous work focused ... -
Strategies for the Direct Coupling of Solid Phase Microextraction to Mass Spectrometry
(University of Waterloo, 2017-09-27)In recent years, advances in direct sample to mass spectrometry (MS) techniques have allowed for the application of these methods towards quantitative analysis in complex matrices such as biofluids and tissue. However, the ... -
Strategies to Improve Solid Phase Microextraction Sensitivity: Temperature, Geometry and Sorbent Effects
(University of Waterloo, 2013-04-24)Solid phase microextraction (SPME) has been widely used in a variety of sample matrices and proven to be a simple, fast and solvent-free sample preparation technique. A challenging limitation in the further development of ... -
Strategies Towards Asymmetric Conjugate Trifluoromethylation of α,β-Unsaturated Ketones and the Asymmetric Conjugate Addition of Boronates to β-Trifluoromethyl α,β-Unsaturated Ketones
(University of Waterloo, 2014-09-02)Currently, there are no reported methods in the literature for the conjugate addition of the trifluoromethyl group to α,β-unsaturated ketones. A bulk of this thesis focused on developing a method to overcome this problem. ... -
Streptococcus agalactiae CAMP factor: Functional Roles of N- and C-terminal Domains & Target Membrane Effect on Toxin Activity
(University of Waterloo, 2018-05-22)CAMP factor is a well-known pore-forming toxin secreted by Streptococcus agalactiae that forms discrete pores on susceptible membranes whether natural or artificial. This work reports haemolysis and liposome permeabilization ... -
Strong Hydrogen Bonds in Anion-Solvent Clusters: Structural and Thermochemical Properties
(University of Waterloo, 2008-08-28)Insight into the effect of secondary interactions, fluorination, as well as substituent effects on strong ionic hydrogen bonds has been acquired through studies of FHF-, NFnH3-n•••F- (n = 0..2) and [M-H]- (M = Glycine, ... -
Structural characterization and engineering of Adnectin inclusion bodies
(University of Waterloo, 2022-08-15)Protein aggregation is a fundamental process occurring as a response to aging, disease, protein overexpression and in many areas of biotechnology and medical applications. There has been much recent progress in determining ... -
Structural characterization of f-ALS associated SOD1 mutant aggregates using conformation-specific antibodies
(University of Waterloo, 2020-06-01)Superoxide dismutase 1 (SOD1) is a metalloenzyme ubiquitously expressed in all cells and acts as an antioxidant enzyme by catalyzing the dismutation of superoxide radicals. Several mutations in the gene encoding SOD1 are ... -
Structural Consequences of Calmodulin EF Hand Mutations
(American Chemical Society, 2017-02-21)Calmodulin (CaM) is a cytosolic Ca2+-binding protein that serves as a control element for many enzymes. It consists of two globular domains, each containing two EF hand pairs capable of binding Ca2+, joined by a flexible ... -
Structural investigation of a new cadmium coordination compound prepared by sonochemical process: Crystal structure, Hirshfeld surface, thermal, TD-DFT and NBO analyses
(Elsevier, 2019-04)A new nanostructured cadmium complex containing a tridentate Schiff base ligand was sonochemically synthesized and characterized by XRPD, FT/IR, NMR, and single crystal X-ray crystallography. Structural data showed that ...