Browsing Chemistry by Title
Now showing items 357-376 of 826
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Identification of functional regions of streptococcus agalactiae CAMP factor
(University of Waterloo, 2008-09-26)Streptococcus agalactiae CAMP factor is a protein exotoxin that contains 226 amino acid residues and forms oligomeric pores on susceptible cell membranes and liposomes. In this study, fragments of CAMP factor were created ... -
Identifying Fenton-Reacted Trimethoprim Transformation Products Using Differential Mobility Spectrometry
(ACS Publications, 2018-04-17)A transformation product of trimethoprim, a contaminant of emerging concern in the environment, is generated using an electro-assisted Fenton reaction and analyzed using differential mobility spectrometry (DMS) in combination ... -
Immature SOD1: protein folding, misfolding and aggregation
(University of Waterloo, 2023-01-25)Protein misfolding and aggregation are hallmarks of many diseases, including amyotrophic lateral sclerosis (ALS). In familial ALS, aberrant self-association of mutant Cu,Zn-superoxide dismutase (SOD1) is implicated as a ... -
Immobilization of DNA on Magnetic Microparticles for Mercury Enrichment and Detection with Flow Cytometry
(Wiley, 2011-04-26)Mercury detection in water has attracted a lot of research interest due to its highly toxic nature and adverse environmental impact. In particular, the recent discovery of specific binding of HgII to thymine-rich (T-rich) ... -
Immunoaffinity Solid Phase Microextraction
(University of Waterloo, 2007-12-18)Biological fluids are commonly analyzed in clinical and forensic studies for drug concentration measurements. Conventional quantification procedures are always associated with lengthy sample pretreatment steps to eliminate ... -
Impact of Single-Walled Carbon Nanotubes on Ciliated Protozoa & Bacteria
(University of Waterloo, 2009-02-02)As pointed out more and more frequently in the literature, there is a pressing need for research into the health and environmental impact of nanoparticles. This work represents a joint effort between scientists in ... -
Impacts on Metabolism and Gill Physiology of Darter Species (Etheostoma spp.) That Are Attributed to Wastewater Effluent in the Grand River
(Multidisciplinary Digital Publishing Institute, 2020-11-25)The effluent from municipal wastewater treatment plants is a major point source of contamination in Canadian waterways. The improvement of effluent quality to reduce contaminants, such as pharmaceuticals and personal care ... -
Improved Models for the Potential Energy Functions of the Ground Singlet and Lowest-Lying Triplet States of the Cesium Dimer
(University of Waterloo, 2012-08-23)The Morse/Long Range (MLR) potential has become one of the most reliable and highly used potential energy functions for diatomic molecules. It includes the theoretical long range behaviour that diatomic molecules are ... -
Improving Biospecimen Imaging in Liquid Phase Electron Microscopy
(University of Waterloo, 2023-08-24)This thesis highlights the progress made in LPEM and the study of biosamples. The introduction provides a comprehensive overview of the challenges encountered in investigating molecular processes and traces the historical ... -
Improving molecularly imprinted nanogels by pH modulation
(Royal Society of Chemistry, 2015-10-16)Molecularly imprinted polymers (MIPs) are polymerized in the presence of a template molecule. After removing the template, the polymer scaffold can selectively rebind the template. The imprinting factor (IF) refers to the ... -
In Search of an Ideal Modulator for Comprehensive Two-Dimensional Gas Chromatography
(University of Waterloo, 2019-10-24)Gas chromatography has been a prevailing technique to separate different mixtures of volatile and semi-volatile compounds in order to qualitatively and quantitatively identify each individual component. With more complex ... -
In vitro selection and biochemical characterization of trivalent metal ion dependent RNA-cleaving DNAzymes
(University of Waterloo, 2016-08-30)DNAzymes are DNA sequences with catalytic activity. So far, all known DNAzymes have been isolated using the high-throughput in vitro selection method. DNAzymes have been used for analytical, biomedical, and nanotechnology ... -
In Vitro Selection in Serum: RNA-Cleaving DNAzymes for Measuring Ca2+ and Mg2+
(American Chemical Society, 2016-05-27)RNA-cleaving DNAzymes have been attempted as in vivo analytical probes and gene silencing reagents over the past two decades. Despite progress already achieved, concerns still exist regarding the activity of DNAzymes in ... -
In Vitro Selection of a DNAzyme Cooperatively Binding Two Lanthanide Ions for RNA Cleavage
(American Chemical Society, 2016-05-03)Trivalent lanthanide ions (Ln(3+)) were recently employed to select RNA-cleaving DNAzymes, and three new DNAzymes have been reported so far. In this work, dysprosium (Dy3+) was used with a library containing 50 random ... -
In Vitro Selection of a New Lanthanide-Dependent DNAzyme for Ratiometric Sensing Lanthanides
(American Chemical Society, 2014-10-07)Developing biosensors for lanthanides is an important but challenging analytical task. To address this problem, in vitro selection of RNA-cleaving DNAzymes was carried out using a library containing a region of 35 random ... -
In Vitro Selection of Chromium-Dependent DNAzymes for Sensing Chromium(III) and Chromium(VI)
(Wiley, 2016-07-04)Chromium is a very important analyte for environmental monitoring, and developing biosensors for chromium is a long-standing analytical challenge. In this work, in vitro selection of RNA-cleaving DNAzymes was carried out ... -
In Vitro Selection of New DNAzymes as Metal Biosensors
(University of Waterloo, 2015-06-26)In vitro selection of metal-specific DNAzymes has been shown to be a powerful method to obtain biosensors for metal ion detection. With 14 independent in vitro selection experiments using each of the trivalent lanthanide ... -
In Vitro Selection, Characterization, and Application of a Sodium-Dependent DNAzyme and a Metal-Independent Ribozyme
(University of Waterloo, 2021-09-20)Ribozymes and DNAzymes are collectively called catalytic nucleic acids. Compared to protein enzymes, catalytic nucleic acids are programmable in structure, easy to synthesize or modify, and more chemically stable especially ... -
In vitro studies of NOS inhibitors using purified human NOS isozymes
(University of Waterloo, 2017-12-18)Endogenous nitric oxide (NO) is derived from L-arginine via a chemical reaction catalyzed by nitric oxide synthases (NOS). Three NOS isozymes are found in humans: neuronal NOS (nNOS), endothelial NOS (eNOS) and inducible ... -
In Vivo Calibration Methods of SPME and Application to Pharmacokinetic Studies
(University of Waterloo, 2009-05-21)Solid phase microextraction (SPME) has gained much popularity for in vivo applications recently. Thus far, there are two types of pre-equilibrium kinetic calibration that have been applied to in vivo SPME: on-fibre ...