Browsing Chemistry by Title
Now showing items 651-670 of 837
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Size-Specific ZrO₂ and HfₓZr₁₋ₓO₂ Nanoclusters and Their Magnetic and Nanodevice Applications
(University of Waterloo, 2024-01-22)Nanoclusters, generally defined as assemblies of a discrete number of atoms or molecules in the size range of 1-10 nm, have attracted a lot of attention due to their unique properties that bridge the gap between isolated ... -
Smart Polymeric Materials by Ring-Opening Metathesis Polymerization
(University of Waterloo, 2017-09-22)The aim of this Thesis work was to address the issue of microbial contamination inside fuel tanks. Microorganisms induce the chemical corrosion of airplane tank walls due to their production of organic acids. Biocide ... -
Solid Phase Microextraction as a Sample Preparation Tool for Targeted and Untargeted Analysis of Biological Matrices
(University of Waterloo, 2017-09-27)Successful determination of small molecules in complex biological systems requires implementation of robust analytical methodologies able to provide reliable information in a cost-effective and efficient manner. Solid phase ... -
Solid phase microextraction coupled to comprehensive two-dimensional gas chromatography–time-of-flight mass spectrometry for metabolite profiling of apples: Potential of non-invasive in vivo sampling assay in characterization of metabolome
(University of Waterloo, 2012-09-21)The objective of the current research project relies on implementation of solvent-free, green and environmentally friendly solid phase microextraction (SPME) sample preparation alternative in the area of complex sample ... -
Solid Phase Microextraction Devices Prepared on Plastic Support as Potential Single-Use Samplers for Bioanalytical Applications
(American Chemical Society, 2015-09-04)This study presents new thin-film solid phase microextraction (SPME) devices prepared on plastic as potential single-use samplers for bioanalysis. Polybutylene terephthalate (PBT) was selected as a support due to its ... -
Solid phase microextraction for in vivo determination of pharmaceuticals in fish and wastewater
(University of Waterloo, 2012-10-26)This thesis describes the development and application of solid phase microextraction (SPME) as a sample preparation technique for in vivo determination of pharmaceutical residues in fish tissue and wastewater. The occurrence, ... -
Solid Phase Microextraction in Aqueous Sample Analysis
(University of Waterloo, 2008-06-26)This thesis presents enhanced analytical methods developed for complex aqueous sample analysis based on solid phase microextraction (SPME). First, the laboratory evaluation of the kinetic calibration approach in aqueous ... -
Solid Phase Microextraction On-Fiber Derivatization Using a Stable, Portable, and Reusable Pentafluorophenyl Hydrazine Standard Gas Generating Vial
(American Chemical Society, 2017-07-05)Solid phase microextraction (SPME) on-fiber derivatization methods have facilitated the achievement of lower detection limits and targeted analysis of various substances that exhibit poor chromatographic behavior, thermal ... -
Solid phase microextraction: a versatile technique for lipid analysis
(University of Waterloo, 2023-04-26)Extensive multidisciplinary research and improvements to instrumentation and workflows are continuously enabling new insights into the role of lipids in health and disease. As with other metabolites, the accurate analysis ... -
Solid Solution Tetrelides and Pnictides for Thermoelectric Applications
(University of Waterloo, 2023-07-17)Recent major advancements in thermoelectric material performance center around the development and understanding of band structure engineering techniques and phonon scattering mechanisms. Solid solution materials have the ... -
Solid State Structures and Transport Properties of Selenazyl Radicals
(University of Waterloo, 2008-08-29)The synthetic routes to the salts of the 3H-naphtho[1,2-d][1,2,3]dithiazolylium cation and its three selenium containing variants are described. The most efficient approach involves the condensation of bis-acetylated ... -
Solid-phase microextraction as sample preparation method for metabolomics
(University of Waterloo, 2010-04-28)The main objective of the emerging field of metabolomics is the analysis of all small molecule metabolites present in a particular living system in order to provide better understanding of dynamic processes occurring in ... -
Solid-Phase Total Synthesis of Dehydrotryptophan-Bearing Cyclic Peptides Tunicyclin B, Sclerotide A, CDA3a and CDA4a using a Protected β-Hydroxytryptophan Building Block
(University of Waterloo, 2021-05-31)The non-proteinogenic amino acid Z-dehydrotryptophan can be found in a several naturally occurring peptide. Amongst them are cyclic peptides such as tunicyclin B, the antifungal agents keramamide F and sclerotide A, as ... -
Solid-State NMR Investigations of 67Zn and 27Al Nuclei in Zinc-Amino Acid Complexes, Zinc-Insulin Hexamers, and Aluminum-Centered Dyes
(University of Waterloo, 2010-02-16)Modern solid-state nuclear magnetic resonance (NMR) methodologies are applied to investigate two spin-5/2 nuclei, Zn-67 and Al-27, in different coordination environments in order to characterize the magnitudes and orientations ... -
Solution Structure of Calmodulin Bound to the Target Peptide of Endothelial Nitric Oxide Synthase Phosphorylated at Thr495
(American Chemical Society, 2014-03-04)Nitric oxide synthase (NOS) plays a major role in a number of key physiological and pathological processes, and it is important to understand how this enzyme is regulated. The small acidic calcium binding protein, calmodulin ... -
Spectrophotometric method for simultaneous measurement of zinc and copper in metalloproteins using 4-(2-pyridylazo)resorcinol
(Elsevier, 2019-08-15)Bound metals are observed in a great many natural proteins, where they perform diverse roles in determining protein folding, stability and function. Due to the broad impact of bound metals on biophysical and biochemical ... -
Spectroscopic Analysis of Resin-Bound Peptides: Glutathione and FK-13
(University of Waterloo, 2014-01-27)High-resolution magic angle spinning (HRMAS) NMR spectroscopy is used to study solid samples that are normally difficult to analyze due to broadening of peaks. Solid-phase peptide synthesis can bind peptides to an insoluble ... -
Spectroscopic interrogation of differential mobility spectrometry selected, isolated, gas-phase molecular clusters
(University of Waterloo, 2020-09-25)One of the most elusive challenges facing mass spectrometry-based methods is the study of isomers. Oftentimes, isomers produce identical fragmentation spectra that make structural elucidation and assignment from MS data ... -
Stability and aggregation propensities of ALS-associated human superoxide dismutase mutants
(University of Waterloo, 2010-02-19)Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease and is characterized by progressive paralysis leading to death, typically, within 3-5 years of the onset of symptoms. The majority of ALS cases ... -
Stability and Aggregation Studies of Immature Superoxide Dismutase
(University of Waterloo, 2015-08-27)Amyotrophic Lateral Sclerosis is a devastating neurological disease with no known cure. In 1993, a genetic link was established between ALS and mutant forms of Cu, Zn-superoxide dismutase (SOD1), an antioxidant enzyme ...