Chemistry
This is the collection for the University of Waterloo's Department of Chemistry .
Research outputs are organized by type (eg. Master Thesis, Article, Conference Paper).
Waterloo faculty, students, and staff can contact us or visit the UWSpace guide to learn more about depositing their research.
Recent deposits
-
Use of (Dihaloiodo)arene Reagents in Halogenation Reactions
(University of Waterloo, 2017-09-18)Halogenation of organic molecules is a fundamental transformation in organic chemistry. Introducing halogens into substrates can be a challenge since most methods for introducing fluorine or chlorine into molecules include ... -
Synthesis and Solution Behaviour of CpFe(CO)(PPh3)[CO(CH2)3N(CH3)2] (FpC3NMe2)
(University of Waterloo, 2017-09-18)Metal carbonyl (MC) colloids in water have a wide range of biomedical applications. The Fp-acyl (Fp: CpFe(CO)2) derivatives are one kind of MC molecules that can be synthesized through migration insertion reaction (MIR). ... -
Surface modification of cellulose nanocrystal for advanced applications
(University of Waterloo, 2017-09-18)Cellulose nanocrystals (CNC) are bio-based nanoparticles, which display an array of interesting properties related to their renewability, biocompatibility, high tensile strength and elastic modulus, high aspect ratio, low ... -
Numerical Modeling of Solid-Phase Microextraction: Binding Matrix Effect on Equilibrium Time
(American Chemical Society, 2015-10-06)Solid-phase microextraction (SPME) is a well-known sampling and sample preparation technique used for a wide variety of analytical applications. As there are various complex processes taking place at the time of extraction ... -
Numerical Simulation and Experimental Validation of Calibrant-Loaded Extraction Phase Standardization Approach
(American Chemical Society, 2016-09-06)We present the kinetics of calibrant release and analyte uptake between the sample and calibrant-loaded extraction phase, CL-EP, with a finite-element analysis (FEA) using COMSOL Multiphysics software package. Effect of ... -
The Study of Carbon Nanotube based Chemi-resistive Portable Biosensors used for the Detection of Bacteria
(University of Waterloo, 2017-09-14)The successful fabrication and characterization of a portable, disposable single walled carbon nanotube biosensor used for the detection of bacteria was demonstrated by this work. The Si/SiO2 based SWNT growth using chemical ... -
Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry
(American Chemical Society, 2017-02-22)The microsolvated state of a molecule, represented by its interactions with only a small number of solvent molecules, can play a key role in determining the observable bulk properties of the molecule. This is especially ... -
The automatic use of capillary isoelectric focusing with whole column imaging detection for carbamazepine binding to human serum albumin
(Elsevier, 2017-08-05)The binding of the anticonvulsant drug carbamazepine (CBZ) to human serum albumin, both without (dHSA) and in the presence of fatty acids (HSA) was studied in real time by capillary isoelectric focusing with whole column ... -
Matrix compatible solid phase microextraction coating, a greener approach to sample preparation in vegetable matrices
(Elsevier, 2017-09-01)This work proposes the novel PDMS/DVB/PDMS fiber as a greener strategy for analysis by direct immersion solid phase microextraction (SPME) in vegetables. SPME is an established sample preparation approach that has not yet ... -
A study of thin film solid phase microextraction methods for analysis of fluorinated benzoic acids in seawater
(Elsevier, 2016-03-04)Fluorinated benzoic acids (FBAs) are frequently used as tracers by the oil industry to characterize petroleum reservoirs. The demand for fast, reliable, robust, and sensitive approaches to separate and quantify FBAs in ... -
Development of a multichannel microfluidic system with Schlieren imaging microscopy for online chip-based moving boundary electrophoresis
(Elsevier, 2017-02-10)The concentration gradient detection method based on the Schlieren optics employed for electrophoresis analyses by extending the technology to a multi-channel system using a prototyped microfluidic chip (thinXXS Micro-technology, ... -
High throughput solid phase microextraction: A new alternative for analysis of cellular lipidome?
(Elsevier, 2017-02-01)A new SPME method for untargeted lipidomic study of cell line cultures was proposed for the first time. In this study the feasibility to monitor changes in lipid profile after external stimuli was demonstrated and compared ... -
Determination of Polycyclic Aromatic Hydrocarbons in Sediment by Pressure-Balanced Cold Fiber Solid Phase Microextraction
(American Chemical Society, 2017-09-20)An improved performance of the cold fiber solid phase micro extraction (CF-SPME) technique was accomplished with the use of the pressure balanced procedure. In order to obtain a pressure-balanced state during extraction ... -
Time Weighted Average Concentration Monitoring Based on Thin Film Solid Phase Microextraction
(American Chemical Society, 2017-04-04)Time weighted average (TWA) passive sampling with thin film solid: phase micro extraction (TF-SPME) and liquid chromatography tandem mass spectrometry (LC-MS/MS) was used for collection, identification, and quantification ... -
Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry
(American Chemical Society, 2017-04-04)In recent years, the direct coupling of solid phase microextraction (SPME) and mass spectrometry (MS) has shown its great potential to improve limits of quantitation, accelerate analysis throughput, and diminish potential ... -
A New Na(+)-specific DNAzyme Mutant from in Vitro Selection
(University of Waterloo, 2017-09-08)Sodium is one of the most ubiquitous metal ions in both intracellular and extracellular fluids. Many fluorescent sensors have been designed to measure Na+ concentrations. However, Na+ binding to biomolecules such as DNA ... -
Asymmetric soft-hard colloidal mixtures: osmotic effects, glassy states and rheology
(American Institute of Physics, 2017-09-06)Whereas mixtures of colloids and non-adsorbing polymers have been studied in great detail in the last two decades, binary colloidal mixtures have not received much attention. Yet, fragmental evidence from asymmetric mixtures ... -
The Saliva Exposome for Monitoring of Individuals’ Health Trajectories
(Environmental Health Perspectives - United States Federal Government, 2017-07-20)Background: There is increasing evidence that environmental, rather than genetic, factors are the major causes of most chronic diseases. By measuring entire classes of chemicals in archived biospecimens, exposome-wide ... -
In vivo microsampling to capture the elusive exposome
(Nature Publishing Group, 2017-03-07)Loss and/or degradation of small molecules during sampling, sample transportation and storage can adversely impact biological interpretation of metabolomics data. In this study, we performed in vivo sampling using solid-phase ... -
pH-Responsive Poly(Ethylene Glycol)- block -Polylactide Micelles for Tumor-Targeted Drug Delivery
(American Chemical Society, 2017-08-16)A biodegradable micellar drug delivery system with a pH-responsive sheddable PEG shell was developed using an acetal-linked poly(ethylene glycol)-block-polylactide (PEG-a-PLA) copolymer and applied to the tumoral release ...
RSS 1.0