• Arborescent Polypeptides for the Targeted and Controlled Release of Drugs 

  Wang, Jun-Zhi (University of Waterloo, 2022-01-20)

  Amphiphilic block copolymer micelles are commonly used as drug delivery agents, but these micelle structures tend to dissociate upon dilution. In contrast, arborescent copolymers are highly branched unimolecular micelles ...

• One-dimensional Nanostructures of Hafnium Oxides: Fabrication with and without Ti/Fe Doping, and Magnetic Properties 

  Beedel, Mahdi (University of Waterloo, 2022-01-10)

  Since the discovery of giant magnetoresistance (GMR) in the late 1980s, which marked the emergence of spintronic technology, the integration of conventional semiconductor-based electronics with spintronics has always been ...

• Next Generation Li-S and Li-O2 Batteries based on Electrode and Electrolyte Design 

  Kwok, Chun Yuen (University of Waterloo, 2022-01-05)

  Decoupling our reliance on fossil fuel as the primary energy source emphasizes battery technology to store intermittent renewable energy such as solar and wind for sectors including grid energy storage, electric transportation, ...

• Structure of Human Cu, Zn Superoxide Dismutase-1 Inclusion Body Aggregates using Quenched Hydrogen-Deuterium Amide Exchange 

  Tarasca, Michael (University of Waterloo, 2021-12-22)

  Inclusion bodies (IBs) are insoluble protein aggregates that can be formed within recombinant bacteria. These aggregates, once thought to be an obstacle in recombinant protein expression and purification, have recently ...

• Fundamentals of SPME extraction of tissue and plasma: experimental and in-silico approaches 

  Huq, Mohammad Maududul (University of Waterloo, 2021-12-15)

  Over the last three decades, solid-phase microextraction (SPME) has continuously evolved and received recognition as a useful tool in various scientific fields. Notable applications have been published including environmental ...

• Applications of Iodonium Ylides for Donor-Acceptor Cyclopropane Synthesis 

  Chidley, Tristan (University of Waterloo, 2021-11-30)

  The application of hypervalent iodine (HVI) reagents in the field of organic chemistry has emerged as a viable option for many different useful organic transformations. There have been many considerable contributions made ...

• Characterization of the Conformation and Internal Backbone Dynamics of a-Polyglucans by Pyrene Excimer Fluorescence 

  Kim, Damin (University of Waterloo, 2021-11-23)

  The conformation and internal backbone dynamics (IBD) of several pyrene-labeled polysaccharides (Py-PSs), namely Py-Amylopectin, Py-Glycogen, Py-Dextran, and Py-Pullulan, were successfully examined with a combination of ...

• Lithium ion conducting inorganic solid electrolytes and all solid-state lithium batteries 

  Zhou, Laidong (University of Waterloo, 2021-11-08)

  As the world transitions away from fossil energy to green and renewable energy, electrochemical energy storage techniques, especially rechargeable batteries, increasingly become a vital component for this transition. High ...

• Identifying Fenton-Reacted Trimethoprim Transformation Products Using Differential Mobility Spectrometry 

  Psutka, Jarrod; Dion-Fortier, Annick; Dieckmann, Thorsten; Campbell, J. Larry; Segura, Pedro; Hopkins, W. Scott (ACS Publications, 2018-04-17)

  A transformation product of trimethoprim, a contaminant of emerging concern in the environment, is generated using an electro-assisted Fenton reaction and analyzed using differential mobility spectrometry (DMS) in combination ...

• Ligand Specificity and Affinity in the Sulforhodamine B Binding RNA Aptamer 

  Piccolo, Kyle; McNeil, Brooke; Crouse, Jeff; Lim, Su Ji; Hopkins, W. Scott; Dieckmann, Thorsten (Elsevier Inc., 2020-07-18)

  Binding affinity and selectivity are critical properties of aptamers that must be optimized for any application. The sulforhodamine B binding RNA aptamer (SRB‐2) is a somewhat promiscuous aptamer that can bind ligands ...

• Nano-confined water within the membrane of self-assembled vesicles 

  Marquez, Audren (University of Waterloo, 2021-10-01)

  The hydrophobic metal carbonyl complexes, known as FpR (Fp = (Cp)Fe(PPh3)(CO)(CO−), Cp = cyclopentadiene, R = C3Bithiophene, C6Pyrene, C6Azobenzene or C6), self-assembles into stable colloids in water. The colloids are ...

• Synthesis and Characterization of Macrocycles via Migration Insertion Polymerization (MIP) 

  LO, PING HSUN (University of Waterloo, 2021-09-30)

  Migration insertion polymerization (MIP) of organometallic monomers, ᴾFpCₓ [ᴾFp = (PPh₂(CH₂)₃Cp)Fe(CO)₂, Cₓ = (CH₂)ₓ₋₁CH₃, X = 12 or 18] were performed ether in bulk or solution. This MIP exclusively produced ring molecules ...

• Part 1: Towards the Synthesis of Pyrene Zigzag Cyclacenes, Part 2: New Methods for the Synthesis of Conjugated Polymers 

  Mirabal, Rafael (University of Waterloo, 2021-09-30)

  Part 1: Carbon nanotubes (CNTs) are allotropes of carbon that have emerged as candidates for implementation in electronic devices ranging from transistors to solar cells. Unfortunately, the behavior of CNTs is highly ...

• Studying the Structure and Kinetics of Functional Nucleic Acids 

  Piccolo, Kyle (University of Waterloo, 2021-09-30)

  Aptamers are valuable tools in a variety of biotechnological applications, ranging from biosensing to in vivo cell imaging. Studying these molecules can further our understanding of the structure and kinetics of nucleic ...

• Low Temperature Insights into the Crystal and Magnetic Structure of a Neutral Radical Ferromagnet 

  Oakley, Richard; Robertson, Craig; Winter, Stephen; Howard, Judith; Probert, Michael (Royal Society of Chemistry, 2021-09-16)

  The crystal structure of the radical ferromagnet 1a at 2 K reveals a contraction in the unit cell c constant which, at the molecular level, translates into a decrease in slippage of the radical π-stacks and an increase in ...

• Characterizing Polymers with Complex Architecture using Pyrene Excimer Fluorescence 

  Thoma, Janine Lydia (University of Waterloo, 2021-09-29)

  This thesis combines two different models, namely the model free analysis (MFA) and the fluorescence blob model (FBM), that were used to study the conformation and internal dynamics of two highly branched macromolecules, ...

• Compact Sparse Coulomb Integrals using a Range-Separated Potential 

  Lecours, Michael (University of Waterloo, 2021-09-24)

  The efficient calculation of so-called two-electron integrals is an important component for electronic structure calculations on large molecules and periodic systems at both mean field and post-HF, correlated, levels. In ...

• Synthesis and Study of the Cyclic Lipopeptide Antibiotics Paenibacterin and Daptomycin 

  Noden, Michael Robert (University of Waterloo, 2021-09-23)

  Cyclic lipopeptides present a rich source of antimicrobial compounds with diverse modes of action. Paenibacterin is a cyclic lipopeptide antibiotic produced by Paenibacillus thaminolyticus that exhibits activity against a ...

• In Vitro Selection, Characterization, and Application of a Sodium-Dependent DNAzyme and a Metal-Independent Ribozyme 

  Ma, Lingzi (University of Waterloo, 2021-09-20)

  Ribozymes and DNAzymes are collectively called catalytic nucleic acids. Compared to protein enzymes, catalytic nucleic acids are programmable in structure, easy to synthesize or modify, and more chemically stable especially ...

• Hybrid Cathode for All-Solid-State Li-S Batteries 

  Xu, Shiqi (University of Waterloo, 2021-09-03)

  Lithium-sulfur (Li-S) battery is one of the most promising energy storage candidates to satisfy the rising demands in multi-functional personal electronics, and the development of electric vehicles due to its high energy ...

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