• Hydrophobic Engineering of a Bacterial Nanodimensional Capsule Protein 

  BEN KRAYEM, OMAIMA RAMADAN (University of Waterloo, 2017-07-07)

  Recently, numerous protein-based nanomedicine platforms have been intensively explored. These systems are usually composed of self-assembling proteins that form controllable systems with different shapes and types. A ...

• Pyrenyl Derivative with a Four-Atom Linker That Can Probe the Local Polarity of Pyrene-Labeled Macromolecules 

  Farhangi, Shiva; Duhamel, Jean (American Chemical Society, 2016-02-04)

  The fluorescent probe 1-pyrenemethoxyethanol (PyMeEGOH) was designed to replace commercially available 1-pyrenebutanol (PyButOH) as an alternative fluorescent label to probe the internal dynamics and interior polarity of ...

• Investigation of Peptides That Exhibit Affinity Towards Advanced Materials 

  Kim, Hyun Seok (University of Waterloo, 2017-05-19)

  A number of commercially employed polymers are refractory to surface modification and may require harsh conditions ranging from corona discharge to halogenation to assemble a functional surface. We are exploring combinatorial ...

• Glassy States in Asymmetric Mixtures of Soft and Hard Colloids 

  Truzzolillo, Domenico; Marzi, Daniela; Marakis, John; Capone, Barbara; Camargo, Manuel; Munam, Abdul; Moingeon, Firmin; Gauthier, Mario; Likos, Christos N.; Vlassopoulos, Dimitris (APS Physics, 2013-11-14)

  By employing rheological experiments, mode coupling theory, and computer simulations based on realistic coarse-grained models, we investigate the effects of small, hard colloids on the glassy states formed by large, soft ...

• Advanced Electrodes and Electrolytes For Long-Lived and High-Energy-Density Lithium-Sulfur Batteries 

  Pang, Quanquan (University of Waterloo, 2017-05-16)

  The increasing demand on renewable but intermittent energy and the need for electrified transportation place great emphasis on energy storage. Lithium-sulfur (Li-S) batteries are promising systems due to the high theoretical ...

• Synthesis, Structure and Electrochemistry of Positive Electrode Materials for Rechargeable Magnesium and Lithium Ion Batteries: Mechanistic Investigations 

  Sun, Xiaoqi (University of Waterloo, 2017-05-12)

  To meet the requirements for high energy density storage systems, rechargeable batteries based on the “beyond lithium ion” technologies have been widely investigated. The magnesium battery is a promising candidate benefiting ...

• Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis 

  Zhou, Wenhu; Yu, Tianmeng; Vazin, Mahsa; Ding, Jinsong; Liu, Juewen (American Chemical Society, 2017-06-07)

  The interaction between chromium ions and DNA is of great interest in inorganic chemistry, toxicology, and analytical chemistry. Most previous studies focused on in situ reduction of Cr(VI), producing Cr3+ for DNA binding. ...

• Profiling Metal Oxides with Lipids: Magnetic Liposomal Nanoparticles Displaying DNA and Proteins 

  Wang, Feng; Zhang, Xiaohan; Liu, Yibo; Lin, Zhi Yuan (William); Liu, Biwu; Liu, Juewen (Wiley, 2016-09-19)

  Metal oxides include many important materials with various surface properties. For biomedical and analytical applications, it is desirable to engineer their biocompatible interfaces. Herein, a phosphocholine liposome (DOPC) ...

• Comparison of Graphene Oxide and Reduced Graphene Oxide for DNA Adsorption and Sensing 

  Lu, Chang; Huang, Po-Jung Jimmy; Liu, Biwu; Ying, Yibin; Liu, Juewen (American Chemical Society, 2016-10-18)

  Fluorescently labeled DNA adsorbed on graphene oxide (GO) is a well-established sensing platform for detecting a diverse range of analytes. GO is a loosely defined material and its oxygen content may vary depending on the ...

• A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence 

  Zhou, Wenhu; Ding, Jinsong; Liu, Juewen (Wiley, 2016-08-17)

  A previous study of two RNA-cleaving DNAzymes, NaA43 and Ce13d, revealed the possibility of a common Na+ aptamer motif. Because Na+ binding to DNA is a fundamental biochemical problem, the interaction between Ce13d and Na+ ...

• Adsorption of Nanoceria by Phosphocholine Liposomes 

  Liu, Yibo; Liu, Juewen (American Chemical Society, 2016-12-13)

  Nanoceria (CeO2 nanoparticle) possesses a number of enzyme-like activities. In particular, it scavenges reactive oxygen species based on in-vitro and in vivo antioxidation studies. An important aspect of fundamental physical ...

• Parallel Polyadenine Duplex Formation at Low pH Facilitates DNA Conjugation onto Gold Nanoparticles 

  Huang, Zhicheng; Liu, Biwu; Liu, Juewen (American Chemical Society, 2016-11-15)

  DNA-functionalized gold nanoparticles (AuNPs) have been extensively used in sensing, drug delivery, and materials science. A key step is to attach DNA to AuNPs, forming a stable and functional conjugate. Although the ...

• A New Na+-Dependent RNA-Cleaving DNAzyme with over 1000-fold Rate Acceleration by Ethanol 

  Zhou, Wenhu; Saran, Runjhun; Chen, Qingyun; Ding, Jinsong; Liu, Juewen (Wiley, 2016-01-15)

  Enzymes working in organic solvents are important for analytical chemistry, catalysis, and mechanistic studies. Although a few protein enzymes are highly active in organic solvents, little is known regarding nucleic ...

• G-Quadruplex DNA for Fluorescent and Colorimetric Detection of Thallium(I) 

  Hoang, Michael; Huang, Po-Jung Jimmy; Liu, Juewen (American Chemical Society, 2016-02-26)

  Thallium is a highly toxic heavy metal, but its 495 nm FRET sensing is underexplored compared to its neighboring elements Blue in the periodic table: lead and mercury. Thallium has two " oxidation states. A DNAzyme-based ...

• Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry 

  Huang, Po-Jung Jimmy; Wang, Feng; Liu, Juewen (American Chemical Society, 2015-03-15)

  The interaction between graphene oxide (GO) and lipid bilayers is important for fundamental surface science and many applications. In this work, isothermal titration calorimetry (ITC), cryo-TEM, and fluorescence spectroscopy ...

• 2-Aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver 

  Zhou, Wenhu; Ding, Jinsong; Liu, Juewen (Elsevier, 2017-01-15)

  Heavy metal detection is a key topic in analytical chemistry. DNA-based metal recognition has advanced significantly producing many specific metal ligands, such as thymine for Hg2+ and cytosine for Ag+. For practical ...

• A Silver DNAzyme 

  Saran, Runjhun; Liu, Juewen (American Chemical Society, 2016-04-05)

  Silver is a very common heavy metal, and its detection is of significant analytical importance. DNAzymes are DNA-based catalysts; they typically recruit divalent and trivalent metal ions for catalysis. Herein, we report a ...

• Molecularly Imprinted Polymers with DNA Aptamer Fragments as Macromonomers 

  Zhang, Zijie; Liu, Juewen (American Chemical Society, 2016-03-16)

  Molecularly imprinted polymers (MIPs) are produced in the presence of a template molecule. After removing the template, the cavity can selectively rebind the template. MIPs are attractive functional materials with a low ...

• A DNAzyme requiring two different metal ions at two distinct sites 

  Zhou, Wenhu; Zhang, Yupei; Huang, Po-Jung Jimmy; Ding, Jinsong; Liu, Juewen (Oxford University Press, 2015-12-10)

  Most previously reported RNA-cleaving DNAzymes require only a single divalent metal ion for catalysis. We recently reported a general trivalent lanthanide-dependent DNAzyme named Ce13d. This work shows that Ce13d requires ...

• Label-Free Ag+ Detection by Enhancing DNA Sensitized Tb3+ Luminescence 

  Kleinke, Kimberly; Saran, Runjhun; Liu, Juewen (Multidisciplinary Digital Publishing Institute, 2016-08-26)

  In this work, the effect of Ag+ on DNA sensitized Tb3+ luminescence was studied initially using the Ag+-specific RNA-cleaving DNAzyme, Ag10c. While we expected to observe luminescence quenching by Ag+, a significant ...

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