Browsing Chemistry by Title
Now showing items 607-626 of 826
-
Rainbow trout exposed to benzo[a]pyrene yields conserved microRNA binding sites in DNA methyltransferases across 500 million years of evolution
(Springer, 2017-12-04)The objective of this study was to examine the regulation of DNA methylation following acute (24 h) and prolonged (14 d) exposure to low (1 ng/L) and high (10 ng/L) benzo[a]pyrene. However, with the recent release of the ... -
Rapid determination of immunosuppressive drug concentrations in whole blood by coated blade spray-tandem mass spectrometry (CBS-MS/MS)
(Elsevier, 2018-01-25)Coated Blade Spray (CBS) is a technology that efficiently integrates sample preparation and direct coupling to mass spectrometry (MS) on a single device. In this article, we present CBS-tandem mass spectrometry (CBS-MS/MS) ... -
Rationally Designed Nucleobase and Nucleotide Coordinated Nanoparticles for Selective DNA Adsorption and Detection
(American Chemical Society, 2013-12-17)Nanomaterials for DNA adsorption are useful for sequence-specific DNA detection. Current materials for DNA adsorption employ electrostatic attraction, hydrophobic interaction, or π–π stacking, none of which can achieve ... -
Recent progress in nanomaterial-enhanced fluorescence polarization/anisotropy sensors
(Elsevier, 2019-09)As a promising signaling transduction approach, fluorescence polarization (FP)/fluorescence anisotropy (FA), provides a powerful quantitative tool for the rotational motion of fluorescently labeled molecules in chemical ... -
Reconstructing quantum molecular rotor ground states
(Physical Review B, 2020-07-06)Nanomolecular assemblies of C60 can be synthesized to enclose dipolar molecules. The low-temperature states of such endofullerenes are described by quantum mechanical rotors, which are candidates for quantum information ... -
A Refined Method for Quantitation of Divalent Metal Ions in Metalloproteins and Local Stability and Conformational Heterogeneity of Amyotrophic Lateral Sclerosis-Associated Cu, Zn Superoxide Dismutase
(University of Waterloo, 2014-05-13)Amyotrophic lateral sclerosis (ALS) is a devastating and progressive disease that results in selective death of motor neurons in the cortex, brain stem and spinal cord. ALS is the most common adult onset motor neuron disease ... -
Regenerable DNA-Functionalized Hydrogels for Ultrasensitive, Instrument-Free Mercury(II) Detection and Removal in Water
(American Chemical Society, 2010-09-15)Mercury is a highly toxic environmental pollutant with bioaccumulative properties. Therefore, new materials are required to not only detect but also effectively remove mercury from environmental sources such as water. We ... -
The Reproductive Effects of Municipal Wastewater Effluents
(University of Guelph, 2017-03-01)There is a growing concern that pharmaceuticals and other chemicals present in the effluents (sewage discharged into a river) from municipal wastewater treatment plants enter the aquatic environment, where they may affect ... -
Reversible and Mechanism-Based Irreversible Inhibitor Studies on Human Steroid Sulfatase and Protein Tyrosine Phosphatase 1B
(University of Waterloo, 2009-10-02)The development of reversible and irreversible inhibitors of steroid sulfatase (STS) and protein tyrosine phosphatase 1B (PTP1B) is reported herein. STS belongs to to the aryl sulfatase family of enzymes that have roles ... -
Reversible gating of ion transport through DNA-functionalized carbon nanotube membranes
(Royal Society of Chemistry, 2017-01-03)Carbon nanotubes (CNTs) can be used to create unique fluidic systems for studying ion transport in nanochannels due to their well-defined geometry, atomically smooth and chemically inert surface, and similarity to transmembrane ... -
Review of geometries and coating materials in solid phase microextraction: Opportunities, limitations, and future perspectives
(Elsevier, 2017-09-01)The development of new support and geometries of solid phase microextraction (SPME), including metal fiber assemblies, coated-tip, and thin film microextraction (TFME) (i.e. self-supported, fabric and blade supported), as ... -
The Role of Carbonic Anhydrase in Promoting CO2 Capture and Operation of Bicarbonate-Fed Electrolyzers
(University of Waterloo, 2022-08-23)Capturing CO2 through chemical absorption offers a sustainable solution to mitigate rising CO2 emissions which are widely agreed to be the primary contributor to climate change. Among various capture solutions, bicarbonate ... -
Role of NOS-like proteins found in bacteria
(University of Waterloo, 2007-01-22)Nitric oxide (•NO) is a molecule with diverse biological effects involved in both signaling and defense mechanisms in mammalian systems. The production of •NO is catalyzed from L-Arginine by a family of enzymes known as ... -
Role of Symmetry in Hisactophilin Folding
(University of Waterloo, 2009-02-23)Hisactophilin is a histidine-rich actin binding protein from Dictyostelium discoideum; it is a member of the β-trefoil superfamily and exhibits a characteristic tertiary structure with three-fold symmetry. The effect of ... -
The Role of Wastewater Testing for SARS-CoV-2 Surveillance
(Ontario COVID-19 Science Advisory Table, 2021-08-26)Wastewater testing for SARS-CoV-2 is relatively new; however, it builds on existing public health surveillance infrastructure. There is a limited but growing evidence base for its use, despite notable interpretation ... -
The Saliva Exposome for Monitoring of Individuals’ Health Trajectories
(Environmental Health Perspectives - United States Federal Government, 2017-07-20)Background: There is increasing evidence that environmental, rather than genetic, factors are the major causes of most chronic diseases. By measuring entire classes of chemicals in archived biospecimens, exposome-wide ... -
Scanning Tunneling Microscopy of Electrically Driven Phase Transitions in a Charge Density Wave Material
(University of Waterloo, 2022-03-25)The 1T polytype of the van der Waals material TaS2, has been studied extensively as a strongly correlated system. Exhibiting several different charge density wave (CDW) states, the phase diagram of 1T-TaS2 has been explored ... -
Searching for a DNAzyme version of the leadzyme
(Springer, 2015-10-12)The leadzyme refers to a small ribozyme that cleaves a RNA substrate in the presence of Pb2+. In an optimized form, the enzyme strand contains only two unpaired nucleotides. Most RNA-cleaving DNAzymes are much longer. Two ... -
Selection and characterization of an aptamer to a thiazole orange derivative for use in a fluorescence-based biosensor
(University of Waterloo, 2023-08-18)Aptamers are short single-stranded DNA or RNA sequences that have been selected in vitro to have a high binding affinity to a specific target molecule. One class of aptamers can bind to small non-fluorescent molecules to ... -
A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence
(Wiley, 2016-08-17)A previous study of two RNA-cleaving DNAzymes, NaA43 and Ce13d, revealed the possibility of a common Na+ aptamer motif. Because Na+ binding to DNA is a fundamental biochemical problem, the interaction between Ce13d and Na+ ...