Now showing items 4-23 of 836

    • Accelerating peroxidase mimicking nanozymes using DNA 

      Liu, Biwu; Liu, Juewen (Royal Society of Chemistry, 2015-09-07)
      DNA-capped iron oxide nanoparticles are nearly 10-fold more active as a peroxidase mimic for TMB oxidation than naked nanoparticles. To understand the mechanism, the effect of DNA length and sequence is systematically ...
    • Accurate Determination of the Diffusion Coefficient of Proteins by Fourier Analysis with Whole Column Imaging Detection 

      Zarabadi, Atefeh; Pawliszyn, Janusz (American Chemical Society, 2015-01-21)
      Analysis in the frequency domain is considered a powerful tool to elicit precise information from spectroscopic signals. In this study, the Fourier transformation technique is employed to determine the diffusion coefficient ...
    • Action Mechanism and Structural Studies on the Lipopeptide Antibiotic Daptomycin 

      Beriashvili, David (University of Waterloo, 2019-07-02)
      Daptomycin (dap) is calcium-dependent lipopeptide antibiotic that is used clinically to treat systemic infections caused by Gram-positive pathogens. It is thought that dap brings about its antimicrobial effect by binding ...
    • The action mechanism of daptomycin 

      Taylor, Scott D.; Palmer, Michael (Elsevier, 2016-12-15)
      Daptomycin is a lipopeptide antibiotic produced by the soil bacterium Streptomyces roseosporus that is clinically used to treat severe infections with Gram-positive bacteria. In this review, we discuss the mode of action ...
    • An Acyl-Linked Dimer of Daptomycin Is Strongly Inhibited by the Bacterial Cell Wall 

      Taylor, Robert; Scott, Bradley; Taylor, Scott D.; Palmer, Michael (American Chemical Society, 2017-03-28)
      The lipopeptide antibiotic daptomycin is active against Gram-positive pathogens. It permeabilizes bacterial cell membranes, which involves the formation of membrane-associated oligomers. We here studied a dimer of daptomycin ...
    • Adnectin Solubility and Dynamics 

      Trainor, Kyle (University of Waterloo, 2019-10-28)
      Rapid growth of the global market for monoclonal antibodies (mAbs) has generated considerable interest in the development of alternative molecules that facilitate rapid discovery and manufacturing, while replicating the ...
    • Adsorption and Desorption of DNA on Graphene Oxide Studied by Fluorescently Labeled Oligonucleotides 

      Wu, Marissa; Kempaiah, Ravindra; Huang, Po-Jung Jimmy; Maheshwari, Vivek; Liu, Juewen (American Chemical Society, 2011-03-15)
      Being the newest member of the carbon materials family, graphene possesses many unique physical properties resulting is a wide range of applications. Recently, it was discovered that graphene oxide can effectively adsorb ...
    • Adsorption of DNA Oligonucleotides by Titanium Dioxide Nanoparticles 

      Zhang, Xu; Wang, Feng; Liu, Biwu; Kelly, Erin Y.; Servos, Mark R.; Liu, Juewen (American Chemical Society, 2014-01-28)
      Titanium dioxide (TiO2) or titania shows great promise in detoxification and drug delivery. To reach its full potential, it is important to interface TiO2 with biomolecules to harness their molecular recognition function. ...
    • Adsorption of DNA onto gold nanoparticles and graphene oxide: surface science and applications 

      Liu, Juewen (Royal Society of Chemistry, 2012-06-28)
      The interaction between DNA and inorganic surfaces has attracted intense research interest, as a detailed understanding of adsorption and desorption is required for DNA microarray optimization, biosensor development, and ...
    • Adsorption of Nanoceria by Phosphocholine Liposomes 

      Liu, Yibo; Liu, Juewen (American Chemical Society, 2016-12-13)
      Nanoceria (CeO2 nanoparticle) possesses a number of enzyme-like activities. In particular, it scavenges reactive oxygen species based on in-vitro and in vivo antioxidation studies. An important aspect of fundamental physical ...
    • Advanced Electrodes and Electrolytes For Long-Lived and High-Energy-Density Lithium-Sulfur Batteries 

      Pang, Quanquan (University of Waterloo, 2017-05-16)
      The increasing demand on renewable but intermittent energy and the need for electrified transportation place great emphasis on energy storage. Lithium-sulfur (Li-S) batteries are promising systems due to the high theoretical ...
    • Advanced Electrolyte Design for Long-Life and High-Areal-Capacity Divalent Metal Batteries 

      Li, Chang (University of Waterloo, 2024-01-22)
      Net-zero carbon dioxide emission demands clean renewable energy, while harnessing it requires electrochemical storage devices with high energy density, safety and affordability. To achieve decarbonization, much effort is ...
    • Advanced research on Lithium-Sulfur battery : studies of lithium polysulfides. 

      Cabelguen, Pierre-Etienne (University of Waterloo, 2013-10-03)
      This thesis was devised as a fundamental study of the Li-S system by the use of 7Li Magic Angle Spinning (MAS) Nuclear Magnetic Resonance (NMR), X-ray Absorption Near- Edge Structure (XANES), and Non-Resonant Inelastic ...
    • Advanced Separation Techniques in the Analysis of Environmental Pollutants 

      El-Hussieny Mohamed, Heba (University of Waterloo, 2012-04-30)
      Recent developments in chromatographic supports and instrumentation for liquid chromatography are enabling rapid and highly efficient separations. Various analytical strategies have been recently proposed, for example the ...
    • Advances in Biamperometry with Applications in Ocular Toxicology 

      Rahimi, Mehdi (University of Waterloo, 2013-10-02)
      This thesis presents advances in biamperometry, together with applications cyclic biamperometry, in in vitro ocular cytotoxicity assessment. For the cytotoxicity/viability assessment, cultured human corneal epithelial cells ...
    • Advances in Multidimensional Chromatography 

      Mostafa, Ahmed Mohamed (University of Waterloo, 2012-07-23)
      Comprehensive two-dimensional gas chromatography (GC×GC) is among the most powerful methods used to separate complex samples. Two columns of different selectivities are coupled in series through a special interface ...
    • Advances in solid-phase microextraction as sample preparation method for food analysis. 

      Souza-Silva, Erica A. (University of Waterloo, 2015-02-25)
      Within all steps involved in the analytical process, sample preparation is considered the most time-consuming step. Therefore, substantial efforts have focused on the search for automated sample preparation strategies that ...
    • Advances in the density matrix renormalization group method for use in quantum chemistry 

      Zgid, Dominika (University of Waterloo, 2008-05-01)
      Despite the success of modern quantum chemistry in predicting properties of organic molecules, the treatment of inorganic systems, which have many close lying states, remains out of quantitative reach for current methods. ...
    • Advances in two-dimensional liquid chromatography 

      Ali, Alshymaa (University of Waterloo, 2022-08-26)
      Comprehensive two-dimensional liquid chromatography (LC×LC) offers increased peak capacity, resolution and selectivity compared to one-dimensional liquid chromatography. It is commonly accepted that the technique produces ...
    • Aggregation of Amyotrophic Lateral Sclerosis-Associated Cu/Zn Superoxide Dismutase 

      Hwang, Young Mi (University of Waterloo, 2010-05-21)
      Amyotrophic lateral sclerosis (ALS) is a devastating, progressive, and fatal neurodegenerative disease. Despite the fact that ALS is the most common motor neuron disease in adulthood, there is no effective treatment for ...


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