Browsing Chemistry by Title
Now showing items 232-251 of 837
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DNA adsorption by magnetic iron oxide nanoparticles and its application for arsenate detection
(Royal Society of Chemistry, 2014-05-01)Iron oxide nanoparticles adsorb fluorescently labeled DNA oligonucleotides via the backbone phosphate and quench fluorescence. Arsenate displaces adsorbed DNA to increase fluorescence, allowing detection of arsenate down ... -
DNA Adsorption by ZnO Nanoparticles near Its Solubility Limit: Implications for DNA Fluorescence Quenching and DNAzyme Activity Assays
(American Chemical Society, 2016-06-07)Zinc oxide (ZnO) is a highly important material, and Zn2+ is a key metal ion in biology. ZnO and Zn2+ interconvert via dissolution and hydrolysis/condensation. In this work, we explore their interactions with DNA, which ... -
DNA Adsorption, Desorption, and Fluorescence Quenching by Graphene Oxide and Related Analytical Application
(University of Waterloo, 2011-09-20)Graphene is a single layer of graphite with many unique mechanical, electrical, and optical properties. In addition, graphene is also known to adsorb wide range of biomolecules including single-stranded DNA. On the other ... -
DNA and Hydrogels for Sensing and Binding Purine Nucleosides
(University of Waterloo, 2021-08-27)Purine nucleosides, such as adenosine and guanosine, are important biomolecules to regulate physiological functions, including maintain heart and brain health, exert inflammatory responses, and take part in metabolisms. ... -
DNA and Metal Ion Mediated Modification of Nanomaterials
(University of Waterloo, 2021-09-01)DNA-modified nanomaterials have been applied in diverse areas such as biosensing, catalysis, drug delivery, and biomedical diagnostics. Metal ion mediated DNA conjugation is an important strategy for the construction of ... -
DNA duplex stabilization in crowded polyanion solutions
(Royal Society of Chemistry, 2013-02-14)The melting temperature of duplex DNA is much higher in polyanions than in non-ionic polymers with similar ionic strength, suggesting an additional electrostatic contribution on top of the excluded volume effect. -
DNA functionalized soft materials: preparation, biophysical properties and analytical applications.
(University of Waterloo, 2013-01-02)Bio-nanotechnology is the use of biomolecules to control both the structure and property of nanomaterials. No biomolecule has been employed more often than DNA as exemplified in the numerous demonstrations of DNA-directed ... -
DNA in Ionic Liquids and Polyelectrolytes
(University of Waterloo, 2013-08-30)DNA has been widely studied in a variety of solvents. The majority of these solvents consist of either aqueous or organic components. The presence of ions or salts in these solvents can further alter DNA properties by ... -
DNA stabilized fluorescent metal nanoclusters for biosensor development
(Elsevier, 2014-03-22)Fluorescent silver, gold and copper nanoclusters (NCs) have emerged for biosensor development. Compared to semiconductor quantum dots, there is less concern about the toxicity of metal NCs, which can be more easily conjugated ... -
DNA stabilized silver nanoclusters for ratiometric and visual detection of Hg2+ and its immobilization in hydrogels
(Elsevier, 2013-04-11)DNA oligomers are particularly interesting templates for making silver nanoclusters (AgNCs) as different emission colors can be obtained by varying the DNA sequence. Many AgNCs have been used as Hg2+ sensors since Hg2+ ... -
DNA-Functionalized Gold Nanoparticles in Macromolecularly Crowded Polymer Solutions
(American Chemical Society, 2012-11-15)DNA-functionalized gold nanoparticles (AuNPs) are one of the most commonly used reagents in nanobiotechnology. They are important not only for practical applications in analytical chemistry and drug delivery, but also for ... -
DNA-Functionalized Monolithic Hydrogels and Gold Nanoparticles for Colorimetric DNA Detection
(American Chemical Society, 2010-12-22)Highly sensitive and selective DNA detection plays a central role in many fields of research, and various assay platforms have been developed. Compared to homogeneous DNA detection, surface-immobilized probes allow washing ... -
DNA-Length-Dependent Fluorescence Signaling on Graphene Oxide Surface
(Wiley, 2012-02-10)Fluorescence energy transfer to graphene oxide is studied using covalently linked DNA probes ranging from 4 to 70 base pairs. The characteristic distance and mechanism of energy transfer are reported. -
DNA/Metal Oxide Nanoconjugates: Fundamental Understandings and Analytical Applications
(University of Waterloo, 2016-07-29)DNA-functionalized nanomaterials have shown versatile applications in biosensor development, biomedical diagnostics, therapy, and catalysis. DNA is attractive for this purpose for its programmable structure, molecular ... -
DNAzyme Hybridization, Cleavage, Degradation and Sensing in Undiluted Human Blood Serum
(American Chemical Society, 2015-04-07)RNA-cleaving DNAzymes provide a unique platform for developing biosensors. However, a majority of the work has been performed in clean buffer solutions, while the activity of some important DNAzymes in biological sample ... -
A DNAzyme requiring two different metal ions at two distinct sites
(Oxford University Press, 2015-12-10)Most previously reported RNA-cleaving DNAzymes require only a single divalent metal ion for catalysis. We recently reported a general trivalent lanthanide-dependent DNAzyme named Ce13d. This work shows that Ce13d requires ... -
Dose-dependent dissociation of pro-cognitive effects of donepezil on attention and cognitive flexibility in rhesus monkeys
(Elsevier, 2021-11)BACKGROUND Donepezil exerts pro-cognitive effects by non-selectively enhancing acetylcholine (ACh) across multiple brain systems. Two brain systems that mediate pro-cognitive effects of attentional control and cognitive ... -
Driving Adsorbed Gold Nanoparticle Assembly by Merging Lipid Gel/Fluid Interfaces
(American Chemical Society, 2015-11-23)Surface forces between inorganic nanoparticles and lipid bilayer is of great relevance to biophysics, medicine, and nanobiotechnology. Adsorbed nanoparticles may influence the fluidity of the underlying lipids, which may ... -
Dynamics and Inhibition of Class II Fructose 1,6-bisphosphate Aldolase
(University of Waterloo, 2009-04-24)It has been suggested for many decades that the essential and ubiquitous enzyme fructose 1,6-bisphosphate aldolase (FBA) could be a good drug target against bacteria and fungi, since lower organisms possess a metal-dependent ... -
Dynamics of Nitric Oxide Synthase–Calmodulin Interactions at Physiological Calcium Concentrations
(American Chemical Society, 2015-03-24)The intracellular Ca2+ concentration is an important regulator of many cellular functions. The small acidic protein calmodulin (CaM) serves as a Ca2+ sensor and control element for many enzymes. Nitric oxide synthase (NOS) ...