Browsing Science (Faculty of) by Title
Now showing items 1517-1536 of 3042
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Investigation of divalent metal ion detection using 17E DNAzyme Biosensor
(University of Waterloo, 2021-04-30)DNAzymes are in vitro selected oligonucleotides that can catalyze reactions, such as RNA cleavage. Most DNAzymes require metal ions as cofactors. Unlike ribozymes, which have been found in nature, all known DNAzymes are ... -
Investigation of Efficient Synthetic Routes to Conjugated Thiophene-S,S-Dioxide-Based Materials
(University of Waterloo, 2020-10-08)Due to their low cost and desirable properties, many recent efforts in the field of semiconductor research have been devoted to the discovery and investigation of organic materials. Within this field, thiophene-based ... -
Investigation of enzymes catalyzing the production of acetaldehyde from pyruvate in hyperthermophiles
(University of Waterloo, 2012-09-26)Extreme thermophiles and hyperthermophiles are microorganisms capable of growing optimally at 65-79°C and 80°C plus, respectively. Many of the enzymes isolated from them are thermostable, which makes them a potential ... -
Investigation of Flavoproteins Involved in the Metabolism of Anaerobic Hyperthermophilic Microorganisms
(University of Waterloo, 2007-09-12)It was estimated that more than one hundred open reading frames in Pyrococcus furiosus and Thermotoga maritima could encode flavoproteins based on the results of motif search and comparison of genomic annotation to the ... -
An investigation of gas phase ion-molecule complexes involving novel binding modes
(University of Waterloo, 2021-04-16)In this thesis, an innovative method is introduced to advance the study of gas phase clusters and used to analyse a number of novel binding modes. The systematic sampling of cluster surfaces (SSCS) routine, introduced in ... -
Investigation of Gas Transport Rates Through a Covered Waste Rock Pile and Synchrotron Studies on the Sulfide Oxidation Reaction
(University of Waterloo, 2017-01-19)This thesis presents a field based investigation into gas transport mechanisms and rates through a waste-rock pile with a low permeable cover, and a synchrotron based study into intermediate sulfidic species that are ... -
An Investigation of Heterogeneity and the Impact of Acidic Regions on Bulk Effluent from a Deconstructed Low Sulfide Waste-Rock Pile
(University of Waterloo, 2017-05-15)Waste rock is a potential source of low quality drainage resulting from oxidation of naturally occurring sulfide minerals. Sulfide oxidation may result in the generation of effluent with elevated concentrations of SO4 and ... -
Investigation of Immature Cu,Zn Superoxide Dismutase 1 Using Variable Temperature NMR
(University of Waterloo, 2020-09-03)Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results in the death of motor neurons in the spinal cord, cortex, and brain stem. The vast majority of ALS cases arise sporadically, but ... -
An investigation of interocular suppression with a global motion task
(University of Waterloo, 2012-10-31)Abstract Purpose: Interocular inhibitory interactions appear to underlie the establishment of ocular dominance. The inhibitory effect leads to suppression of the non dominant eye in certain conditions. While these ... -
The Investigation of Isomers using Differential Mobility Spectrometry and Ultraviolet Photodissociation Spectroscopy
(University of Waterloo, 2022-10-26)The analysis of complex mixtures in mass spectrometry (MS) is often complicated by the presence of isomers exhibiting the same mass-to-charge ratios. Tandem MS can simplify isomer analysis and enable ion characterization ... -
An investigation of low energy quasiparticle excitations via thermal conductivity measurements
(University of Waterloo, 2012-10-26)Thermal conductivity measurements are made on a variety of systems in order to probe low energy quasiparticle excitations. In particular, thermal conductivity measurements were made on the iron based superconducting ... -
An investigation of low energy quasiparticle excitations via thermal transport measurements
(University of Waterloo, 2017-06-16)Thermal transport measurements can provide a unique perspective of the nature of a system by exploring the behaviour of the low energy excitations from the ground state. Delocalized quasiparticle excitations can affect ... -
Investigation of Peptides That Exhibit Affinity Towards Advanced Materials
(University of Waterloo, 2017-05-19)A number of commercially employed polymers are refractory to surface modification and may require harsh conditions ranging from corona discharge to halogenation to assemble a functional surface. We are exploring combinatorial ... -
Investigation of Pharmaceutical Compounds in Landfill and Septic System Plumes
(University of Waterloo, 2008-11-21)Two municipal landfills and one public septic system in Southern Ontario were studied as potential sources of the pharmaceuticals ibuprofen, carbamazepine, gemfibrozil, caffeine, sulfamethoxazole, and naproxen to groundwater. ... -
An Investigation of Phosphorous-Based Bioconjugation Techniques for Protein Modification
(University of Waterloo, 2022-04-07)Bioconjugation is a powerful technique allowing for the modification of biomolecules such as proteins. Exposed amino acid residues on the surface of proteins act as chemical handles for the attachment of biomolecules or ... -
Investigation of Photon Interactions with Semiconductor Quantum Dot Devices for Quantum Communication Applications
(University of Waterloo, 2020-01-21)A major goal in the field of quantum communication is to achieve long-distance (>100 km) transmission of quantum information, which would allow for the formation of a global quantum network. Devices called 'quantum repeaters' ... -
INVESTIGATION OF PROTEIN-DRUG INTERACTION USING CAPILLARY ISOELECTRIC FOCUSING WITH WHOLE COLUMN IMAGING DETECTION AND SPECTROSCOPIC TECHNIQUES
(University of Waterloo, 2009-03-26)In this work, the possibilities of understanding protein-drug interactions and the possible modes of action of the drug have been was explored using capillary isoelectric focusing (CIEF) and spectroscopic techniques. The ... -
The Investigation of Tear Film Osmolality as a Clinical Instrument Used in Assessments of the Tear Film and Dry Eye Disease
(University of Waterloo, 2010-01-11)Introduction: Tear film osmolality is a product of the varying concentrations of dissolved solutes (proteins, lipids and mucins) in the tear fluid. Research suggests that a hyperosmotic tear film is a trait common to ... -
Investigation of the effect mutations of CaM have upon in vitro and ex vivo function
(University of Waterloo, 2010-01-22)Calmodulin (CaM) is a calcium-binding protein that has promiscuous regulatory interactions with over three hundred intracellular protein targets. The focus of this study was to characterize the functional role of phosphorylated ... -
Investigation of the Efficacy of in situ Degradation Methods for Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonic Acid (PFOS) in Groundwater
(University of Waterloo, 2018-01-17)Per- and polyfluoroalkyl substances (PFASs) are a group of emerging contaminants that include perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS). PFASs can be released into groundwater through the ...