Browsing Science (Faculty of) by Title
Now showing items 1226-1245 of 2849
-
“I gained a skill and a change in attitude”: A Case Study Describing How an Online Continuing Professional Education Course for Pharmacists Supported Achievement of Its Transfer-to-Practice Outcomes
(The Canadian Association for University Continuing Education, 2014-11-27)The convenience and flexibility of online learning clearly make it an attractive option for learners in professional development contexts. There is less clarity, however, about how it fares as a vehicle for enabling the ... -
Ice Flow Shift, Drumlin, and Bedrock Topography Effects on Glacial Dispersal from Kimberlites in the Lac de Gras Region, Northwest Territories, Canada
(University of Waterloo, 2022-05-20)Glaciations of the Quaternary Period have had a profound impact on the Canadian landscape and surficial sediments. Understanding glacial landforms and sediments has thus helped develop fundamental knowledge of past glaciations ... -
Identification and characterization of toxic cyanobacteria in two forested maritime watersheds in North America
(University of Waterloo, 2021-06-01)Healthy forested watersheds naturally provide high quality drinking water to communities. However, the integrity and quality of these water sources may be threatened by climate change-exacerbated disturbances such as ... -
Identification of functional regions of streptococcus agalactiae CAMP factor
(University of Waterloo, 2008-09-26)Streptococcus agalactiae CAMP factor is a protein exotoxin that contains 226 amino acid residues and forms oligomeric pores on susceptible cell membranes and liposomes. In this study, fragments of CAMP factor were created ... -
Identification of genes regulated by the Drosophila transcription factor Hindsight
(University of Waterloo, 2013-05-24)Hindsight (HNT) is a zinc finger transcription factor that is required for morphogenesis of the Drosophila embryo, having roles in germ band retraction (GBR) as well as dorsal closure (DC). HNT expression is also found in ... -
Identification of MH Class IIβ alleles conferring resistance/susceptibility to Flavobacterium psychrophilum in Oncorhynchus mykiss families
(University of Waterloo, 2014-12-11)Flavobacterium psychrophilum is the causative agent of bacterial cold water disease (BCWD), which is a major concern for aquaculture and fish health, with mortality rates of 20-30%. Without a commercially approved vaccine, ... -
Identification of Oil Sands Naphthenic Acid Structures and Their Associated Toxicity to Pimephales promelas and Oryzias latipes
(University of Waterloo, 2013-01-25)The oil sands, located in north-eastern Alberta, are one of the largest deposits of oil worldwide. Because the Alberta Environmental Protection and Enhancement Act prohibits the release of oil sands process-affected material ... -
Identifying Fenton-Reacted Trimethoprim Transformation Products Using Differential Mobility Spectrometry
(ACS Publications, 2018-04-17)A transformation product of trimethoprim, a contaminant of emerging concern in the environment, is generated using an electro-assisted Fenton reaction and analyzed using differential mobility spectrometry (DMS) in combination ... -
Identifying signaling differences between GPCR-induced growth factor receptor transactivation and direct ligand activation
(University of Waterloo, 2014-04-01)Growth factor receptors have significant effects on various normal function of body such as cell proliferation, differentiation and apoptosis. They are also involved in neuronal function and dysfunction, cardiovascular ... -
Identifying the mechanism of Aβ42 inhibition of PDGF-BB signalling
(University of Waterloo, 2014-01-23)Alzheimer’s disease is a late-onset neurological disorder characterized by extracellular aggregates of Aβ plaques and neurofibrillary tangles of hyperphosphoryated tau protein resulting in neuronal dysfunction, cognitive ... -
Image Restoration Methods for Retinal Images: Denoising and Interpolation
(University of Waterloo, 2015-04-27)Retinal imaging provides an opportunity to detect pathological and natural age-related physiological changes in the interior of the eye. Diagnosis of retinal abnormality requires an image that is sharp, clear and free of ... -
Immature SOD1: protein folding, misfolding and aggregation
(University of Waterloo, 2023-01-25)Protein misfolding and aggregation are hallmarks of many diseases, including amyotrophic lateral sclerosis (ALS). In familial ALS, aberrant self-association of mutant Cu,Zn-superoxide dismutase (SOD1) is implicated as a ... -
Immobilization of DNA on Magnetic Microparticles for Mercury Enrichment and Detection with Flow Cytometry
(Wiley, 2011-04-26)Mercury detection in water has attracted a lot of research interest due to its highly toxic nature and adverse environmental impact. In particular, the recent discovery of specific binding of HgII to thymine-rich (T-rich) ... -
Immobilization of Gold Nanoparticles for Colourimetric and Ratiometric Refractive Index Sensing
(University of Waterloo, 2019-12-12)The development of refractive index sensors is an expanding field of research, with applications in fields including medical diagnostics, food safety and public health. Nanotechnology has become widely implemented in various ... -
Immunoaffinity Solid Phase Microextraction
(University of Waterloo, 2007-12-18)Biological fluids are commonly analyzed in clinical and forensic studies for drug concentration measurements. Conventional quantification procedures are always associated with lengthy sample pretreatment steps to eliminate ... -
Immunogenicity and antitumor activity of the superlytic λF7 phage nanoparticles displaying a HER2/neu-derived peptide AE37 in a tumor model of BALB/c mice
(Elsevier, 2018-06-28)Phage display technique has been increasingly researched for vaccine design and delivery strategies in recent years. In this study, the AE37 (Ii-Key/HER-2/neu 776–790) peptide derived from HER2 (human epidermal growth ... -
Impact of Cadmium On The Hypothalamus-Pituitary-Interrenal Axis Function in Rainbow Trout
(University of Waterloo, 2013-04-30)Cadmium (Cd) is a nonessential metal present in sublethal concentrations within the aquatic environment. Cd is an endocrine disruptor and high concentrations of this metal suppress stressor-induced cortisol production in ... -
Impact of Climate Change on Canadian Water Resources: A Continental-Scale Hydrologic Modelling Study Using Multiple RCM Projections
(University of Waterloo, 2015-05-20)Evidence of climate change is mounting and there is nowadays an increasing international scientific consensus that current climate change is, in part, induced by anthropogenic emissions of greenhouse gases. Climate change ... -
Impact of contact lens wear on epithelial alterations in keratoconus
(Elsevier, 2021-03)Purpose The purpose of this study was to characterize the central epithelial thickness (CET) of penetrating keratoplasty corneal specimens obtained from patients with keratoconus (KC) and correlate the histological patterns ... -
Impact of Geological Conceptualization on the Calibration of Groundwater Models at the Mannheim Wellfield, Kitchener, Ontario
(University of Waterloo, 2018-12-10)This study investigates the importance of geological data on the calibration of groundwater models using long term pumping/injection and monitoring well records at a wellfield in the Region of Waterloo, Ontario. Four ...