Browsing Chemistry by Title
Now showing items 21-40 of 826
-
Advances in two-dimensional liquid chromatography
(University of Waterloo, 2022-08-26)Comprehensive two-dimensional liquid chromatography (LC×LC) offers increased peak capacity, resolution and selectivity compared to one-dimensional liquid chromatography. It is commonly accepted that the technique produces ... -
Aggregation of Amyotrophic Lateral Sclerosis-Associated Cu/Zn Superoxide Dismutase
(University of Waterloo, 2010-05-21)Amyotrophic lateral sclerosis (ALS) is a devastating, progressive, and fatal neurodegenerative disease. Despite the fact that ALS is the most common motor neuron disease in adulthood, there is no effective treatment for ... -
Algorithms for quantum molecular dynamics: from matrix product states to path integrals
(University of Waterloo, 2021-01-13)This thesis describes several novel approaches in quantum molecular dynamics for obtaining properties of molecular systems in different regimes. We investigate ground state properties of chains of linear rotors with ... -
Amplifying the Macromolecular Crowding Effect Using Nanoparticles
(American Chemical Society, 2012-01-11)The melting temperature (Tm) of DNA is affected not only by salt but also by the presence of high molecular weight (MW) solutes, such as polyethylene glycol (PEG), acting as a crowding agent. For short DNAs in a solution ... -
Application of matrix compatible solid phase microextraction (SPME) coatings for the analysis in complex food matrices
(University of Waterloo, 2020-01-06)In recent years, studies regarding food analysis have increased due to the globalization of food trade as well as concerns about the safety and traceability of food commodities. In this regard, the field of food analysis ... -
Application of Microwave‐Assisted Technologies for the Analysis of Chlorinated Solvents in Rock Samples
(University of Waterloo, 2012-01-25)It has been a direction for research of late to examine the extraction process of volatile organic compounds (VOCs) from solid matrices. Removal of VOCs from a solid matrix can be challenging due to the nature of the analyte ... -
Application of Pyrene Fluorescence to the Characterization of Hydrophobically Modified Starch Nanoparticles
(American Chemical Society, 2018-06-25)Several aspects of pyrene fluorescence were applied to gain an insight into the nature of the microdomains in hydrophobically modified starch nanoparticles (HM-SNPs), prepared by reacting SNPs with propionic and hexanoic ... -
Application of Solid Phase Microextraction for Lipid Analysis and Lipidomics
(University of Waterloo, 2016-01-29)Although the latest advancements in lipid analysis technology provide an excellent opportunity for the comprehensive study of lipidome, fulfilling the analytical requirements at the desired quality is still a major ... -
Application of solid phase microextraction for quantification of polyunstarurated fatty acids in biological fluids
(ACS, 2014)Development of a straightforward strategy for simultaneous quantitative analysis of nonesterified fatty acids (NEFA) species in biofluids is a challenging task because of the extreme complexity of fatty acid distribution ... -
Application of Solid Phase Microextraction for Quantitation of Polyunsaturated Fatty Acids in Biological Fluids
(American Chemical Society, 2014-11-17)Development of a straightforward strategy for simultaneous quantitative analysis of nonesterified fatty acids (NEFA) species in biofluids is a challenging task because of the extreme complexity of fatty acid distribution ... -
Application of Squaric acid to The Preparation of Bioactive Compounds
(University of Waterloo, 2008-08-28)Nucleosides and nucleoside analogues exhibit a broad spectrum of biological activities including antiviral, anticancer, antibacterial and antiparasitic activities, which generally result from their ability to inhibit ... -
Applications of Iodonium Ylides for Donor-Acceptor Cyclopropane Synthesis
(University of Waterloo, 2021-11-30)The application of hypervalent iodine (HVI) reagents in the field of organic chemistry has emerged as a viable option for many different useful organic transformations. There have been many considerable contributions made ... -
Applications of Membrane Extraction with a Sorbent Interface
(University of Waterloo, 2009-01-22)Membrane extraction with a sorbent interface (MESI) is a sample preparation technique with a rugged and simple design allowing for solvent-free, on-line performance. When coupled to gas chromatography (GC), MESI is an ... -
Approaches to the Inhibition of Class II Fructose-1,6-Bisphosphate Aldolase
(University of Waterloo, 2009-05-22)Fructose-1,6-bisphosphate (FBP) aldolase (E.C. 4.1.2.13) catalyzes the reversible aldol condensation of dihydroxyacetonephosphate (DHAP) and glyceraldehyde-3-phosphate (G3P) in glycolysis, gluconeogenesis and the Calvin ... -
Aptamer-based biosensors for biomedical diagnostics
(Royal Society of Chemistry, 2014-06-07)Aptamers are single-stranded nucleic acids that selectively bind to target molecules. Most aptamers are obtained through a combinatorial biology technique called SELEX. Since aptamers can be isolated to bind to almost any ... -
Aptamer-Based Detection of Caffeine and Theophylline Through Utilization of Gold Nanoparticles and Graphene Oxide
(University of Waterloo, 2023-04-26)The caffeine and theophylline aptamers were used in tandem with gold nanoparticles and graphene oxide to study potential methods for small molecule detection. The AuNP approach is a label-free approach, and the graphene ... -
Aptamer-Functionalized Hydrogel Microparticles for Fast Visual Detection of Mercury(II) and Adenosine
(American Chemical Society, 2012-04-25)With a low optical background, high loading capacity, and good biocompatibility, hydrogels are ideal materials for immobilization of biopolymers to develop optical biosensors. We recently immobilized mercury and lead binding ... -
Arborescent Copolymers: Synthesis, Properties & Metallic Nanoparticle Templating
(University of Waterloo, 2011-08-26)Graft copolymers with a dendritic (arborescent) architecture and unimolecular micelle properties have been synthesized and examined for their solution properties as well as their ability to serve as templates for the ... -
Arborescent Core–Shell–Corona Copolymers by Self-Assembly as Templates for the Preparation of Metallic Nanoparticles
(University of Waterloo, 2020-11-19)The preparation of metallic nanoparticles has been a rapidly growing field of research in recent years, because of the unique physical properties and applications of these materials. The development of applications for ... -
Arborescent Poly(L-glutamic acid)s as Standards to Study the Dense Interior of Polypeptide Mesoglobules by Pyrene Excimer Fluorescence
(American Chemical Society, 2018-10-01)A series of arborescent poly(l-glutamic acid)s of generations 0 to 3 (PGA(GY) with Y = 0–3) were randomly labeled with 1-pyrenemethylamine to yield several Py-PGA(GY) constructs with pyrene contents ranging between 2.5 and ...