Browsing Science (Faculty of) by Title
Now showing items 1319-1338 of 3018
-
Immunogenicity and antitumor activity of the superlytic λF7 phage nanoparticles displaying a HER2/neu-derived peptide AE37 in a tumor model of BALB/c mice
(Elsevier, 2018-06-28)Phage display technique has been increasingly researched for vaccine design and delivery strategies in recent years. In this study, the AE37 (Ii-Key/HER-2/neu 776–790) peptide derived from HER2 (human epidermal growth ... -
Impact of Cadmium On The Hypothalamus-Pituitary-Interrenal Axis Function in Rainbow Trout
(University of Waterloo, 2013-04-30)Cadmium (Cd) is a nonessential metal present in sublethal concentrations within the aquatic environment. Cd is an endocrine disruptor and high concentrations of this metal suppress stressor-induced cortisol production in ... -
Impact of Climate Change on Canadian Water Resources: A Continental-Scale Hydrologic Modelling Study Using Multiple RCM Projections
(University of Waterloo, 2015-05-20)Evidence of climate change is mounting and there is nowadays an increasing international scientific consensus that current climate change is, in part, induced by anthropogenic emissions of greenhouse gases. Climate change ... -
Impact of contact lens wear on epithelial alterations in keratoconus
(Elsevier, 2021-03)Purpose The purpose of this study was to characterize the central epithelial thickness (CET) of penetrating keratoplasty corneal specimens obtained from patients with keratoconus (KC) and correlate the histological patterns ... -
Impact of Geological Conceptualization on the Calibration of Groundwater Models at the Mannheim Wellfield, Kitchener, Ontario
(University of Waterloo, 2018-12-10)This study investigates the importance of geological data on the calibration of groundwater models using long term pumping/injection and monitoring well records at a wellfield in the Region of Waterloo, Ontario. Four ... -
Impact of Geometric Uncertainties on Dose Calculations for Intensity Modulated Radiation Therapy of Prostate Cancer
(University of Waterloo, 2008-01-29)IMRT uses non-uniform beam intensities within a radiation field to provide patient-specific dose shaping, resulting in a dose distribution that conforms tightly to the planning target volume (PTV). Unavoidable geometric ... -
Impact of in vitro Tear Film Composition on Lysozyme Deposition and Denaturation
(University of Waterloo, 2012-08-31)Purpose To study the impact of lactoferrin and lipids on the kinetic deposition and denaturation of lysozyme on contact lens materials. Methods The contact lenses investigated in this thesis included two silicone ... -
Impact of Light Scatter on the Assessment of Retinal Arteriolar Hemodynamics
(University of Waterloo, 2010-04-29)Introduction and Purpose: Vascular pathologies play an important role in the etiology and progression of number of ocular diseases. Many instruments are developed to monitor retinal hemodynamics, including the Canon Laser ... -
Impact of non-steroidal anti-inflammatory drugs on the adaptive responses to stress in rainbow trout
(University of Waterloo, 2007-06-19)Pharmaceutical drugs are used extensively by humans and domestic animals. The detection of compounds such as non-steroidal anti-inflammatory drugs (NSAIDs) in effluents of sewage treatment plants and surface waters has ... -
The impact of prescription medication cost coverage on optimal adherence to Hypertension and Diabetes Mellitus oral medications
(University of Waterloo, 2018-02-26)Background: It can be difficult for patients who do not have prescription medication cost coverage to adhere to their medications. No previous study has examined the time-trend and impact of absence of coverage on adherence ... -
Impact of sex and pathophysiology on optimal drug choice in hypertensive rats: Quantitative insights for precision medicine
(Elsevier, 2021-04)Less than half of all hypertensive patients receiving treatment are successful in normalizing their blood pressure. Despite the complexity and heterogeneity of hypertension, the current antihypertensive guidelines are not ... -
Impact of Single-Walled Carbon Nanotubes on Ciliated Protozoa & Bacteria
(University of Waterloo, 2009-02-02)As pointed out more and more frequently in the literature, there is a pressing need for research into the health and environmental impact of nanoparticles. This work represents a joint effort between scientists in ... -
Impact of the antidepressant venlafaxine on the hypothalamus-pituitary-interrenal axis function in rainbow trout
(University of Waterloo, 2014-05-27)Over the recent years, venlafaxine has become the predominant antidepressant drug detected in municipal wastewater effluents (MWWE) and aquatic systems. However, very little is known about the effect of this drug in the ... -
Impact of the Wisconsinian Glaciation on Canadian Continental Groundwater Flow
(University of Waterloo, 2007-01-19)During the Quaternary period, cyclic glaciations have occurred over a global scale as the result of a climatic variability that affected the Earth's atmospheric, oceanic and glacial systems. Quaternary glaciations and their ... -
Impact of water activity on microbial growth in bentonite clay
(University of Waterloo, 2023-08-11)Canada is in the process of designing and implementing a deep geological repository (DGR) for long-term storage of used nuclear fuel. This proposed storage structure will be a multi-barrier system placed 500-800 metres ... -
Impact of Wavefront-Guided Laser in situ Keratomileusis on Monochromatic Higher Order Aberrations and Vision
(University of Waterloo, 2008-07-04)Wavefront-guided (WFG) laser in situ keratomileusis (LASIK) differs from conventional surgery by applying a refined algorithm for tissue removal, based on information from preoperative wavefront aberration data. Since the ... -
Impact of Winter Soil Processes on Nutrient Leaching in Cold Region Agroecosystems
(University of Waterloo, 2021-02-25)High-latitude cold regions are warming more than twice as fast as the rest of the planet, with the greatest warming occurring during the winter. Warmer winters are associated with shorter periods of snow cover, resulting ... -
Impacts of acute and anthropogenic stress on fish microRNA
(University of Waterloo, 2021-12-21)Fishes play crucial roles in the ecology of aquatic environments and contribute to the multi-billion-dollar fisheries industry. The integrity of their populations and health needs to be maintained for future generations ... -
Impacts of Dredging and Brush Cutting of Paired Agricultural Drainage Ditches on GHG Emissions and Nutrient Filtration Capacity
(University of Waterloo, 2023-01-04)Agriculture provides many beneficial and essential ecosystem services. Along with these beneficial services, the conversion of natural ecosystems into heavily modified agricultural ecosystems is also a source of ... -
Impacts of Ethanol in Gasoline on Subsurface Contamination
(University of Waterloo, 2009-10-09)The increasing use of ethanol as a gasoline additive has raised concerns over the potential impacts ethanol might have on groundwater contamination. In North America, 10% ethanol is commonly being added to gasoline (termed ...