Browsing Science (Faculty of) by Type "Doctoral Thesis"
Now showing items 61-80 of 975
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Bacterial Chromosome Engineering for Applications in Metabolic Engineering
(University of Waterloo, 2015-10-02)As genetic engineering technologies continue to advance and metabolic engineering projects become more ambitious, the need for chromosome engineering tools is increased. In this thesis, I have described the development of ... -
Bacteriophage M13 as a Template for Multi-Enzyme Assembly
(University of Waterloo, 2019-09-25)An important aspect of bionanotechnology is the utilization of biomolecules to prepare controlled and defined arrangements of multiple components with nanoscale order. Bacteriophage M13 is a filamentous phage composed of ... -
Behaviour of Mesoporous Silica (MCM-41) Supported Catalysts in Degradation Reactions
(University of Waterloo, 2013-01-08)A research project was carried out to investigate several aspects of Mobil’s composition of matter #41 (MCM-41) pertaining to its potential application in water treatment technologies. The goal of the work was to lead to ... -
The behavioural ecology of burbot, Lota lota: Diel migrations, spatial behavioural syndromes, and behavioural thermoregulation in a reservoir resident.
(University of Waterloo, 2015-08-21)While the impacts of hydropower development on diadromous and riverine fish species have received considerable attention, the ecology and behaviour of fish species residing in hydropower reservoirs is not well understood. ... -
Benthic-pelagic coupling and spatial dynamics of nutrient availability for benthic nuisance algae in the rocky nearshore zone of eastern Lake Erie
(University of Waterloo, 2019-09-03)Nuisance Cladophora growth in the nearshore during the summer growing season tends to imply nutrient, particularly phosphorus (P), enrichment in the benthos, especially where there is adequate light and hard substrate that ... -
Beta-parvin Mediates Adhesion Receptor Cross-Talk During Xenopus laevis Gastrulation
(University of Waterloo, 2013-09-27)Modulation of cell adhesion is essential to the cell rearrangements that characterize Xenopus gastrulation. The spatial and temporal regulation of cell movement requires a highly coordinated cross-talk between cadherin and ... -
Bifocals in children with Down syndrome (BiDS)
(University of Waterloo, 2010-07-28)Down syndrome (DS) is the most common genetic cause of mental challenge in individuals and is associated with many ocular disorders. One of these anomalies which is frequently present in this population is reduced accommodation ... -
Binocular vision and fixational eye movements
(University of Waterloo, 2017-07-19)Introduction In observers with amblyopia, abnormal patterns of amblyopic eye (AME) fixational eye movements (FEM) have been associated with monocular (reduced amblyopic eye visual acuity) and binocular sensory deficits ... -
Bio-optical Modeling of Aquatic Photosynthesis in the Laurentian Great Lakes
(University of Waterloo, 2010-05-19)The methodology of phytoplankton production measurements in the Laurentian Great Lakes and other freshwater lakes has remained largely unchanged in the past 40 years. In most studies photosynthesis from a single water ... -
Biochemical and Biophysical Investigations of Non-Zinc Dependent Glyoxalase I Enzymes
(University of Waterloo, 2008-09-26)The principal methylglyoxal (MG)-detoxifying system in most living organisms is the two metalloenzyme Glyoxalase system. Glyoxalase I (GlxI) initially converts the non-enzymatically formed MG-GSH hemithioacetal to the ... -
Biochemical and Microbiological Investigations of Inhibitors for β-Lactamases from Human Pathogenic Bacteria
(University of Waterloo, 2019-04-30)The majority of antibiotics prescribed for treatment of bacterial infections are β-lactam antibiotics. Resistance to these has evolved in a few different ways, notably by regulating permeability and by the expression of ... -
Biochemical Investigations of L-Methionine gamma-lyase 1 from Trichomonas vaginalis
(University of Waterloo, 2011-12-16)The enzyme L-methionine γ-lyase (MGL) utilizes a pyridoxal-5’-phosphate-cofactor in order to convert L-methionine to α-ketobutyrate, ammonia and methyl mercaptan. MGL is proposed to be a potential drug target since it is ... -
Bioinformatic insights into the diversity and evolution of bacterial toxins
(University of Waterloo, 2020-01-24)Bacterial toxins are a broad category of molecules ranging from small organic compounds and peptides to large multi-domain or multi-meric enzymes. Several important diseases are caused primarily by bacterial toxins including ... -
Bioinformatic Insights into the Impacts of External Stimuli on the Human Airway
(University of Waterloo, 2021-12-21)The airway epithelium represents a critical component of the human lung that helps orchestrate defences against inhaled substances including air pollution, allergens, bacteria, and viruses. To manage these continuous ... -
Biological responses in rainbow darter (Etheostoma caeruleum) to changes in municipal wastewater quality in the Grand River
(University of Waterloo, 2017-09-27)This thesis is a synthesis of studies that explore the effects of urbanization on a small-bodied fish species, rainbow darter (Etheostoma caeruleum), in the central Grand River (Ontario, Canada) over time. This watershed ... -
BIOMECHANICAL ALTERATION OF CORNEAL MORPHOLOGY AFTER CORNEAL REFRACTIVE THERAPY
(University of Waterloo, 2006)<strong>Purpose:</strong> Although orthokeratology (non-surgical corneal reshaping, Corneal Refractive Therapy, CRT®) has been used for almost a half century, contemporary CRT's outcomes and mechanisms still require ... -
Biophysical Modelling of Antimicrobial Peptide’s Interactions with Phospholipid and Lipopolysaccharide Membranes
(University of Waterloo, 2019-05-23)Antimicrobial peptides (AMPs) are naturally-occurring peptide antibiotics. The way they work has inspired a vigorous search for optimized peptide antibiotics for fighting resistant bacteria. Cationic AMPs cleverly utilize ... -
Biophysical Studies of Lipid Membranes and their Interactions with Amyloid Peptides
(University of Waterloo, 2015-06-19)Amyloid beta peptides are known to form amyloid fibrils which are implicated in more than 20 currently incurable neurodegenerative diseases, including Alzheimer’s, Huntington’s and Parkinson’s. The proposed mechanism of ... -
Biosensing at an individually addressable electrochemical array
(University of Waterloo, 2006)In this thesis, a novel electrochemical array is reported. The array consists of two planar halves, each having four carbon screen-printed band electrodes (SPEs), orthogonally facing each other and separated by a spacer ... -
Black hole dynamics in Effective Field Theory extensions to General Relativity
(University of Waterloo, 2023-09-22)This thesis aims to develop and implement mathematical and numerical techniques to enable the study of deviations from General Relativity (GR) in the nonlinear regime. The focus is on studying the nonlinear dynamics of ...