Browsing Science (Faculty of) by Title
Now showing items 1689-1708 of 3049
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Medication Review in Cognitive Impairment and Dementia: Comparison of Instruments
(University of Waterloo, 2023-12-19)Background: - Cognitive impairment (CI) and dementia are significant concerns in older adults in Canada. Drug-related problems (DRPs) are common and can cause up to 30% of hospitalizations in older individuals, including ... -
Membrane and Arrayed Nanofluidic Devices with High Density Aligned Carbon Nanotubes
(University of Waterloo, 2015-06-15)Exceptionally high aspect ratio, smooth hydrophobic graphitic walls, and nanoscale inner diameters of carbon nanotubes (CNTs) cause the unique phenomenon of efficient transport of water and gas through these nanoscale ... -
Membrane binding and oligomer formation by the calcium-dependent lipopeptide antibiotic A54145: a quantitative study with pyrene excimer fluorescence
(Elsevier, 2016-09-20)A54145 is a lipopeptide antibiotic related to daptomycin that permeabilizes bacterial cell membranes. Its action requires both calcium and phosphatidylglycerol in the target membrane, and it is accompanied by the formation ... -
A Membrane Biosensor for the Detection of Lactate in Body Fluids
(University of Waterloo, 2019-01-31)The increased demand of real-time and convenient heath monitoring has spurned the rapid development of wearable health monitoring devices. In these devices, the central part is the sensor that can convert health information ... -
Membrane Interactions of Streptococcus agalactiae's CAMP factor
(University of Waterloo, 2007-09-27)CAMP factor is an extracellular pore-forming toxin secreted by the group B streptococci Streptococcus agalactiae. In conjunction with the action of sphingomyelinase secreted by Staphylococcus aureus, which converts membrane ... -
Membrane-Disrupting Activity of Antimicrobial Peptides and the Electrostatic Bending of Membranes
(University of Waterloo, 2010-05-21)Antimicrobial peptides (AMPs) are not only fast microbe-killing molecules deployed in the host defense of living organisms but also offer valuable lessons for developing new therapeutic agents. While the mode of action of ... -
Mercury distribution and speciation in biochar particles reacted with contaminated sediment up to 1030days: A synchrotron- based study
(Elsevier, 2019-04-20)A previous long-term microcosm experiment showed mercury (Hg) in the aqueous phase of contaminated sediment was effectively stabilized through the addition of biochar. The present study focuses on the application of ... -
Mercury dynamics in the anadromous Arctic char (Salvelinus alpinus) and food webs of inner Frobisher Bay, Nunavut
(University of Waterloo, 2022-07-06)Mercury (Hg) is a ubiquitous toxic metal that bioaccumulates in organisms and biomagnifies in food webs. Evaluating Hg bioaccumulation and biomagnification in Arctic marine ecosystems is critical for understanding Hg ... -
Mercury Stabilization in Contaminated Sediment by Co-blending with Solid-Phase Reactive Media
(University of Waterloo, 2016-09-01)Mercury (Hg) is a toxic heavy metal and environmental contaminant that can accumulate in both terrestrial and aquatic environments. Pollutant Hg is derived primarily from anthropogenic sources such as mining, coal burning ... -
Mercury Transformation and Release from Contaminated Soil Following Perturbations in Solution Chemistry and Application of Polysulfide
(University of Waterloo, 2018-04-09)Mercury (Hg) is a contaminant of concern due to the very high toxicity and bioaccumulating nature of organic Hg and the persistent leaching of Hg to water bodies from contaminated soils and sediments. The deleterious ... -
Meso – and Neoarchean tectonic evolution of the northwestern Superior Province: Insights from a U-Pb geochronology, Nd isotope, and geochemistry study of the Island Lake greenstone belt, Northeastern Manitoba
(University of Waterloo, 2011-01-21)What tectonic processes were operating in the Archean, and whether they were similar to the “modern-style” plate tectonics seen operating today, is a fundamental question about Archean geology. The Superior Province is the ... -
Messier 87: A Laboratory for Exploring AGN Variability using the Event Horizon Telescope
(University of Waterloo, 2020-09-17)At a distance of 50 million light years at the heart of the Virgo cluster, lies the giant elliptical galaxy Messier 87. This galaxy has at its center a brilliant relativistic jet, observable at all wavelengths, and at the ... -
Metabolic Engineering Sinorhizobium meliloti and Pseudomonas putida for Novel Polymer Production
(University of Waterloo, 2015-03-03)S. meliloti belongs to nitrogen-fixing Rhizobia, the members of the Rhizobiales order of the α-proteobacteria. It can establish a symbiotic relationship with the Leguminosae family of flowering plants. In addition, it is ... -
Metabolic engineering strategies for biomanufacturing of chemicals using Yarrowia lipolytica and Escherichia coli
(University of Waterloo, 2024-04-24)This dissertation advances metabolic engineering by optimizing the genetic and metabolic capabilities of Yarrowia lipolytica and Escherichia coli to enhance their applications in biotechnology. It focuses on improving Y. ... -
Metabolism, transport, and physiologically based pharmacokinetic modelling of novel tacrine derivatives
(University of Waterloo, 2015-08-26)Alzheimer’s disease (AD) is the most prevalent form of dementia affecting the elderly population, and its burden is rapidly growing both in Canada and worldwide. As a result, there is a substantial need for more effective ... -
Metabolomic Profiling of Nutrient Solutions for Characterization of Human Gut Microbiota
(University of Waterloo, 2015-01-06)Studying the metabolite output, the “exometabolome,” of bacterial communities provides insight into the metabolic interactions occurring within that ecosystem. As such, a metabolomic approach can be used to gain further ... -
A Metagenomic Examination of Virus Diversity, Host Interactions, and Genetic Potential Across Municipal Waste Sites
(University of Waterloo, 2023-09-18)Viruses are the most abundant microbial guild on the planet, impacting microbial community structure and ecosystem services. Despite this, they have been underrepresented in reference databases compared to Bacteria and ... -
Metal Isotope Fractionation Associated with Cu and Zn Attenuation by Zero-Valent Iron in Anaerobic Flow-Through Cell Experiments
(University of Waterloo, 2018-01-12)Metal stable isotope fractionation is an emerging tool in the environmental sciences for studying biogeochemical pathways for cycling of metals in the environment. Copper and zinc are essential elements for many biological ... -
Metal loads in an urban catchment (Don River, Ontario)
(University of Waterloo, 2015-01-19)The Don River watershed has been called the most urbanized watershed in Canada. Trace metals are common contaminants in urban areas that may threaten ecosystems at high concentrations. Major urban sources of trace metal ... -
Metal Mixture Toxicity to Hyalella azteca: Relationships to Body Concentrations
(University of Waterloo, 2008-01-25)A literature review of metal mixture interaction analyses identified that there was not a consistent method to determine the impact of metal mixtures on an aquatic organism. The review also revealed that a majority of the ...