Browsing Theses by Title
Now showing items 1848-1867 of 15697
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Characterization of the pro-apoptotic function of eIF5A in human cancer cell lines
(University of Waterloo, 2007-09-18)Eukaryotic translation initiation factor 5A (eIF5A) is the only known protein containing the unique amino acid, hypusine. eIF5A is present in all eukaryotic cells and is highly conserved, but its function is not well ... -
Characterization of the Quasi-Static and Fatigue Behavior of Forged AZ31B Magnesium Alloy
(University of Waterloo, 2018-04-17)Light-weighting is being aggressively targeted by automotive manufacturers as a method to reduce emissions. Magnesium (Mg) alloys due to their low density and high specific strength have therefore gained significant interest ... -
Characterization of the role of Orc6 in the cell cycle of the budding yeast <em>Saccharomyces cerevisiae</em>
(University of Waterloo, 2006)The heterohexameric origin recognition complex (ORC) acts as a scaffold for the G1 phase assembly of pre-replicative complexes. Only the Orc1-5 subunits are required for origin binding in budding yeast, yet Orc6 is an ... -
Characterization of the Self-Assembly of Pyrene-Labelled Macromolecules in Water
(University of Waterloo, 2010-05-19)The self-assembly of several pyrene-labelled amphiphilic macromolecules in water was characterized by fluorescence. Information on their self-assembly was obtained by monitoring the level of pyrene aggregation in solution. ... -
Characterization of Three-Level Control in Capacitively-Shunted Flux Quantum Circuits Using Randomized Benchmarking
(University of Waterloo, 2021-05-12)Superconducting devices have emerged as leading candidates for building practical quantum computers, owing to their scalability, designability, and ease of control. Development of superconducting devices has been accompanied ... -
Characterization of Ti-5553 parts printed by Selective Laser Melting (SLM)
(University of Waterloo, 2018-12-20)Nowadays, titanium alloys are widely used in a variety of industries like automotive and aerospace due to their high strength to weight ratio. Ti-5%Al-5%V-5%Mo-3%Cr is a metastable near beta titanium alloy with excellent ... -
Characterization of Two Novel Voltage-gated Calcium Channel Beta Subunits from Lymnaea stagnalis
(University of Waterloo, 2010-03-01)In excitable tissues, voltage-gated calcium channel activity is critical in the linkage of electrical stimuli to physiological responses, and so modulation of calcium channels therefore has significant implications. The ... -
Characterization of Various Pyrene-Labelled Macromolecules in Solution by Fluorescence
(University of Waterloo, 2010-11-04)Time-resolved fluorescence was applied to linear and branched pyrene-labelled macromolecules to study their internal dynamics. The linear macromolecules consisted of two series of pyrene-labelled poly(N-isopropylacrylamide)s ... -
The characterization of γH2AX as a biomarker of genotoxicity in Oncorhynchus mykiss
(University of Waterloo, 2017-05-19)Environmental contamination due to by-products and waste from industrial activities is a growing universal concern, especially regarding the impact on water and the aquaculture industry. Conventional tests to diagnose ... -
Characterization on PAR-3 in early Xenopus laevis development
(University of Waterloo, 2013-01-24)Polarized cell movements are essential to the cell rearrangements that occur during morphogenesis. In Xenopus, cell polarity is reflected in the directional cell intercalations that drive the morphogenetic movements ... -
Characterization, Quantification and Modification of Starch Nanoparticles
(University of Waterloo, 2014-09-22)Natural polymers, such as polysaccharides, have the potential to replace petroleum-based polymers in certain industrial applications. Ecosphere® starch nanoparticles (ENPs), produced by EcoSynthetix Inc., are starch-based ... -
Characterization, Verification and Control for Large Quantum Systems
(University of Waterloo, 2015-03-31)Quantum information processing offers potential improvements to a wide range of computing endevaors, including cryptography, chemistry simulations and machine learning. The development of practical quantum information ... -
Characterizing a Novel Enzyme Involved in Cardiolipin Remodelling
(University of Waterloo, 2023-12-05)Background: Cardiolipin (CL) is a specialized dimeric phospholipid comprising approximately 25% of total phospholipids in the inner mitochondrial membrane in eukaryotes, where it functions in energy metabolism, autophagy ... -
Characterizing a role for α-parvin in Xenopus laevis Development
(University of Waterloo, 2021-09-20)In metazoans dynamic regulation of cell adhesion is critical for the cell movements that characterize gastrulation. It is clear that the adhesive property of cells is modulated in a highly coordinated spatial and temporal ... -
Characterizing and Modeling the Effects of Mode Mixity and Bond Line Thickness on the Traction-Separation Response of Structural Adhesive Joints
(University of Waterloo, 2021-04-28)As adhesive bonding continues to become more prevalent in automotive structures, the need for high fidelity characterization and modelling of adhesive joints has gained in importance. In this thesis, new specimen geometry ... -
Characterizing and Modelling Tailings Hydrogeochemistry Under a Composite Cover at the Abandoned Kam Kotia Mine, ON
(University of Waterloo, 2023-01-09)A principal environmental concern associated with mining is the weathering of mine waste in the presence of oxygen and water that generates acid mine drainage (AMD) concentrated in toxic elements. Installation of composite ... -
Characterizing and Modelling the Strain Rate-Dependent Constitutive Response of a Unidirectional Non-Crimp Fabric Composite Material
(University of Waterloo, 2023-09-19)Liquid molded composite materials comprising heavy-tow non-crimp fabric reinforcements are increasingly being used for primary load-bearing structures in the automotive sector due to their excellent specific mechanical ... -
Characterizing Aspects of Groundwater Flow in Discontinuous Permafrost Terrain, Within the Central Mackenzie Valley, NWT
(University of Waterloo, 2021-05-26)With recent developments in oil and gas exploration technologies that have opened regions of Canada’s northern territories and the threat of climate change, uncertainties around how these factors may impact the environment ... -
Characterizing Changes in Dipeptidyl Peptidase IV/CD26 on Colon Carcinoma Cells in Response to Prostaglandin Treatment
(University of Waterloo, 2018-08-01)Dipeptidyl peptidase IV (DPPIV) – also known as CD26 – is a multifunctional transmembrane protease found on the surface of most human cells, and shows variable expression between different types of cancer. DPPIV activity ... -
Characterizing Chromium Isotope Fractionation During Reduction of Cr(VI): Batch and Column Experiments
(University of Waterloo, 2012-02-22)Chromium (VI) is a pervasive groundwater contaminant that poses a considerable threat to human health. Remediation techniques have focused on the reduction of the highly mobile Cr(VI) to the sparingly soluble, and less ...