Browsing Pharmacy by Type "Doctoral Thesis"
Now showing items 1-20 of 31
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5-HT7 Receptor Neuroprotection against Excitotoxicity in the Hippocampus
(University of Waterloo, 2014-04-11)Introduction and Objectives: The PDGFβ receptor and its ligand, PDGF-BB, are expressed throughout the central nervous system (CNS), including the hippocampas. Several reports confirm that PDGFβ receptors are neuroprotective ... -
Analysis of plasma chemokines and circulating tumour cells in colorectal and breast cancer patient peripheral blood
(University of Waterloo, 2020-01-22)Circulating tumour cells (CTCs) provide a prognostic value in solid tumours including colorectal and breast. Enumeration of tumour cells from blood is becoming a common practice in informing prognosis and may guide therapy ... -
The associations between insulin, hypoglycemia, and dementia: Combating threats to internal validity in a series of population-based cohort studies
(University of Waterloo, 2023-05-01)Although the association between type 2 diabetes and dementia is recognized, findings from the epidemiology literature on the effect of insulin and one of its side effects, hypoglycemia, are less clear. The currently ... -
Cationic Gelatin/Pluronic-based Nanoparticles as Novel Non-Viral Delivery Systems for Gene Therapy
(University of Waterloo, 2018-08-09)A delivery system is essential to protect the DNA from degradation because of the extracellular and intracellular barriers. Two main types of delivery systems have been used to deliver genes into the body: viral and non-viral ... -
Communicating health information in primary care: a multidisciplinary exploration of patient, pharmacist, and physician decision-making
(University of Waterloo, 2019-06-27)Research has yet to clearly define how health care professionals’ (HCPs) use and sharing of information influences how health decisions are made, both independently and collaboratively. Similarly, the manner in which ... -
Construction and characterization of a hybrid bacteriophage gene delivery platform
(University of Waterloo, 2022-04-26)Bacteriophages, viruses that specifically infect bacteria, may be considered as structurally simplistic protein-based vehicles for ferrying nucleic acid cargo. Since phages cannot infect nor replicate within human cells, ... -
Construction and Characterization of a Robust in vivo Technology for the Production of Superior DNA Vectors for Gene Therapy and Vaccination
(University of Waterloo, 2013-09-27)Plasmid DNA (pDNA) vectors are the current conventional technology driving therapeutic gene transfer, whether for use toward mal/nonfunctional gene replacement, DNA vaccination, or production of therapeutic proteins in ... -
Design and Characterization of Various Lipid, Polymer, and Gemini-Surfactant – Based Vectors and DNA as Non-Viral Delivery Systems for Gene Therapy Applications
(University of Waterloo, 2023-08-31)The bulk of this thesis work is the result of a pharmaceutical collaboration, and it utilizes several proprietary systems. While Chapters 3 and 4 will provide an in-depth discussion of the results, the specific names, ... -
Development and characterization of stimuli-responsive drug delivery systems to prevent HIV infection and the treatment of chronic wounds
(University of Waterloo, 2021-06-10)Patient compliance is very important and highly depends on the drug dosage form which correlates with the success of therapy. Drug delivery systems can be adapted to different pharmaceutical ingredients and to different ... -
Development of a Framework for Identifying Critical Input Parameters for Effective Pediatric PBPK/PBTK Modelling
(University of Waterloo, 2023-01-20)Within a physiologically based pharmacokinetic (PBPK) model framework, virtual children are built based on known trajectories of anatomy and physiology across age and a compounds transfer within the body is defined by ... -
Development of a Novel, Microemulsion System for the Simultaneous Delivery of Hydrophilic and Hydrophobic Active Pharmaceutical Ingredients (APIs)
(University of Waterloo, 2020-09-28)Concurrent chronic disease and ensuing multi-morbidity are a debilitating reality for millions of Canadians. This adversity is compounded by increased pill burden and decreased patient adherence. Microemulsions (MEs) serve ... -
Development of in vitro 3D model systems for screening non-viral neurotrophic factor gene therapies for the retina
(University of Waterloo, 2018-08-21)Glaucoma is a neurodegenerative disease that can lead to a complete loss of vision due to retinal ganglion cell (RGC) death. Therapies that have the capacity to protect and rescue stressed RGCs remain a critical unmet need ... -
Development of Novel Molecules as Modulators of Amyloid-β Aggregation
(University of Waterloo, 2021-09-08)Our brain is remarkably special and unique. It has billions of neurons that govern actions and reactions, and enables us to have thoughts, memories, and personality traits – outmost precious assets – that define who we are ... -
Development of Peptide-Modified Gemini Nanoplexes for Gene Delivery to the Retina
(University of Waterloo, 2020-04-22)Glaucoma is a retinal neurodegenerative disease where the retinal ganglion cells (RGCs) suffer from damage and die over time due to multiple factors, including a persistently elevated intraocular pressure (IOP). Glaucoma ... -
GPCR and RTK Regulation in Neurons: The Impact of Stress on GPCR and RTK signalling and Crosstalk
(University of Waterloo, 2020-04-14)Crosstalk between receptors allows for the integration of diverse and complex signalling pathways. Transactivation is a form of crosstalk between G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). ... -
In-Silico Methods for De-Risking the Clinical Development of Subcutaneously Administered Therapeutic Macromolecules
(University of Waterloo, 2016-07-27)Prediction of human pharmacokinetics (PK) following subcutaneous (SC) administration to animals is challenged by potential interspecies differences in skin anatomy and physiology. With respect to biologic or macromolecule ... -
In-solution and physical state properties of polymer and lipid excipients and their effects on the supersaturation evolution of poorly water-soluble drugs
(University of Waterloo, 2023-04-14)Solubility has become an increasing issue for the pharmaceutical industry, as the advances in combinatorial chemistry and high throughput screening methods have resulted in an increase in the molecular weight and lipophilicity ... -
Integration of Smart Multidose Blister Packaging for Medication Management
(University of Waterloo, 2022-04-26)Medication non-adherence can lead to non-optimal management of chronic diseases and poor health outcomes. Numerous innovative dispensing products offering real-time medication intake monitoring are being developed and ... -
The Interplay Between the Neuronal Plasma Membrane and Cell Signaling in Alzheimer’s Disease
(University of Waterloo, 2023-03-10)The lack of understanding in the molecular and cellular mechanisms of Alzheimer’s disease (AD) has hindered efforts towards finding treatments that effectively modify disease trajectory. Therapeutic development for AD has ... -
Mixed Micelle Characterization of Pluronic and Gemini Surfactant – Based Gene Therapy Carriers and a Connection to Transfection Efficiency
(University of Waterloo, 2020-09-16)Non-viral gene therapy formulation development often relies on a rational design approach, where vector components are selected based on individual characteristics known to favour transfection efficiency. However, these ...