Pharmacy
This is the collection for the University of Waterloo's School of Pharmacy , which includes papers submitted at the conclusion of pharmacy residencies administrated by the School of Pharmacy.
Research outputs are organized by type (eg. Master Thesis, Article, Conference Paper).
Waterloo faculty, students, and staff can contact us or visit the UWSpace guide to learn more about depositing their research.
Recent deposits
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Investigating the Interactions of Fatty Acids, Amyloid Beta & SARS-CoV-2 Spike Protein Fragment
(University of Waterloo, 2023-05-16)There is no cure for Alzheimer’s disease (AD), and the negative implications of having AD were further exacerbated in recent years, as patients with dementia are at the highest risk for mortality upon contracting COVID-19. ... -
Pediatric Physiologically Based Pharmacokinetic (PBPK) Modeling to Advance Knowledge of Breastfeeding Infant Exposure to Maternal Medications
(University of Waterloo, 2023-05-04)While there are benefits of breastfeeding to the maternal-infant pair, mothers taking medication may decide not to breastfeed amid unclear risks of exposing the infant to the drug through milk. Uncertainty arises mainly ... -
The associations between insulin, hypoglycemia, and dementia: Combating threats to internal validity in a series of population-based cohort studies
(University of Waterloo, 2023-05-01)Although the association between type 2 diabetes and dementia is recognized, findings from the epidemiology literature on the effect of insulin and one of its side effects, hypoglycemia, are less clear. The currently ... -
Pharmacokinetic and economic implications when switching between hemophilia A treatments
(University of Waterloo, 2023-04-18)Hemophilia is a bleeding disorder in which the blood is unable to form clots, and is also classified as severe (defined as having an endogenous factor VIII [FVIII] concentration < 1 IU/dL, or 1%), moderate (1-5%) or mild ... -
In-solution and physical state properties of polymer and lipid excipients and their effects on the supersaturation evolution of poorly water-soluble drugs
(University of Waterloo, 2023-04-14)Solubility has become an increasing issue for the pharmaceutical industry, as the advances in combinatorial chemistry and high throughput screening methods have resulted in an increase in the molecular weight and lipophilicity ... -
Clinical Pharmacy Services in Ambulatory Oncology: An Environmental Scan of the Canadian Practice Landscape
(University of Waterloo, 2023-02-21)Background: Canadian clinical pharmacy key performance indicators (cpKPIs) have been developed for inpatient hospital practice but are not established for ambulatory oncology. This study represents the first step in ... -
Evaluation of a microlearning module on hypertension in Canada
(University of Waterloo, 2023-02-20)Objectives: To use a microlearning platform to evaluate pharmacists’ knowledge and behaviour related to hypertension. Methods: Pharmacy 5in5 is an online microlearning platform designed to help pharmacy professionals ... -
The Interplay Between the Neuronal Plasma Membrane and Cell Signaling in Alzheimer’s Disease
(University of Waterloo, 2023-03-10)The lack of understanding in the molecular and cellular mechanisms of Alzheimer’s disease (AD) has hindered efforts towards finding treatments that effectively modify disease trajectory. Therapeutic development for AD has ... -
Development of a Framework for Identifying Critical Input Parameters for Effective Pediatric PBPK/PBTK Modelling
(University of Waterloo, 2023-01-20)Within a physiologically based pharmacokinetic (PBPK) model framework, virtual children are built based on known trajectories of anatomy and physiology across age and a compounds transfer within the body is defined by ... -
The construction and characterization of a synthetic SARS VLP comprised of betacoronavirus consensus sequence-encoded viral components
(University of Waterloo, 2022-12-22)In 2019, a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged from Wuhan, China leading to the COVID-19 pandemic. Although there was an outbreak of severe acute respiratory syndrome ... -
Design of a DNA-Encoded Human Papilloma Virus-Like Particle Displaying a Vascular Endothelial Growth Factor Antagonistic Peptide for Characterization in Mammalian Cells
(University of Waterloo, 2022-12-21)Cancer immunotherapy has evolved as an effective platform for the treatment of a variety of cancer types by enhancing and/or modulating the functionality of the immune system to target cancer cells and consequently mitigate ... -
Understanding the dynamics and molecular interactions of the human cannabinoid receptor 1
(University of Waterloo, 2022-08-23)Cannabinoid receptor 1 (CB1), one of the most populated G-protein coupled receptors (GPCR) present within the brain, is involved in various physiological and homeostatic processes. These pathways include metabolism and ... -
Model-Based Estimation of the Prevalence of Chronic Hepatitis B in Canada and Cost-Effectiveness Analysis of Implementing a Universal Birth Hepatitis B Vaccination Program in Ontario, Canada
(University of Waterloo, 2022-07-26)BACKGROUND Hepatitis B is a potentially life-threatening acute or chronic disease that is caused by hepatitis B virus (HBV). The development of chronic disease is age-dependent, with the highest risk in the infant population. ... -
A bacteria-responsive drug release platform for the local treatment of bacterial vaginosis
(University of Waterloo, 2022-07-25)Bacterial vaginosis (BV) is a common vaginal anaerobic dysbiosis affecting millions of women, with a high recurrence rate probably due to the stubborn existence of biofilms and Gardnerella vaginalis (G. vaginalis) as the ... -
Pharmacy5in5: Evaluating a computer-based education platform to improve pharmacists’ knowledge and behaviour
(University of Waterloo, 2022-05-30)Background The pharmacist’s role continues to evolve and expand from the traditional role of dispensing to a more patient-centered model of care. However, many pharmacists still fall short in terms of their provision of ... -
Endocannabinoids as Amyloid-Beta (Aβ) Aggregation Inhibitors
(University of Waterloo, 2022-05-13)The endocannabinoid system, including endogenous cannabinoids and their corresponding receptors, has received extensive attention in the last few years for their neuroprotective effect in the central nervous system. The ... -
Integration of Smart Multidose Blister Packaging for Medication Management
(University of Waterloo, 2022-04-26)Medication non-adherence can lead to non-optimal management of chronic diseases and poor health outcomes. Numerous innovative dispensing products offering real-time medication intake monitoring are being developed and ... -
Construction and characterization of a hybrid bacteriophage gene delivery platform
(University of Waterloo, 2022-04-26)Bacteriophages, viruses that specifically infect bacteria, may be considered as structurally simplistic protein-based vehicles for ferrying nucleic acid cargo. Since phages cannot infect nor replicate within human cells, ... -
Impact of sex and pathophysiology on optimal drug choice in hypertensive rats: Quantitative insights for precision medicine
(Elsevier, 2021-04)Less than half of all hypertensive patients receiving treatment are successful in normalizing their blood pressure. Despite the complexity and heterogeneity of hypertension, the current antihypertensive guidelines are not ... -
Sex differences in solute and water handling in the human kidney: Modeling and functional implications
(Elsevier, 2021-06)The kidneys maintain homeostasis by controlling the amount of water and electrolytes in the blood. That function is accomplished by the nephrons, which transform glomerular filtrate into urine by a transport process mediated ...
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