Browsing Pharmacy by Type "Doctoral Thesis"
Now showing items 21-31 of 31
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Parameterization of In Silico Oral Disposition Models: Focus on Pediatrics
(University of Waterloo, 2017-03-16)Owing to their biologically relevant design, physiologically-based pharmacokinetic (PBPK) models require quantitative knowledge of organism anatomy and physiology to facilitate appropriate parameterization. Within such ... -
Pediatric Physiologically Based Pharmacokinetic (PBPK) Modeling to Advance Knowledge of Breastfeeding Infant Exposure to Maternal Medications
(University of Waterloo, 2023-05-04)While there are benefits of breastfeeding to the maternal-infant pair, mothers taking medication may decide not to breastfeed amid unclear risks of exposing the infant to the drug through milk. Uncertainty arises mainly ... -
Peptide-Driven Tri-Modal Gene Delivery Systems (PDTMG): Novel Versatile Peptide-Based Lipopolyplexes Incorporating Peptide-Functionalized Gemini Surfactants for Targeted Gene Therapy- Implementation of RGD Motifs as a Means for Endosomal Escape
(University of Waterloo, 2018-09-04)The development of non-viral gene delivery vectors is highly challenging and aims to provide a safe while cost-effective manufacturing alternative to viral vectors. Eleven novel gemini surfactants (G4-G14) were designed ... -
Pharmacokinetic and economic implications when switching between hemophilia A treatments
(University of Waterloo, 2023-04-18)Hemophilia is a bleeding disorder in which the blood is unable to form clots, and is also classified as severe (defined as having an endogenous factor VIII [FVIII] concentration < 1 IU/dL, or 1%), moderate (1-5%) or mild ... -
Pharmacokinetic modelling of clinically relevant situations in the treatment of hemophilia A and B
(University of Waterloo, 2020-04-03)Hemophilia is a congenital bleeding disorder caused by deficiency of clotting factor VIII (FVIII; hemophilia A) or IX (FIX; hemophilia B). Severe hemophilia patients have less than 1% (or 1 IU/dL) of normal factor activity, ... -
Pharmacy5in5: Evaluating a computer-based education platform to improve pharmacists’ knowledge and behaviour
(University of Waterloo, 2022-05-30)Background The pharmacist’s role continues to evolve and expand from the traditional role of dispensing to a more patient-centered model of care. However, many pharmacists still fall short in terms of their provision of ... -
Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Children
(University of Waterloo, 2021-06-25)The following thesis chapters chronicle evolving efforts throughout 2016 – 2021 to support research toward improving the pediatric clinical pharmacology of monoclonal antibodies (mAbs). Translating the benefits of successful ... -
Shades of gray in vaccine decision making: Understanding, exploring, and addressing the challenges of influenza vaccine hesitancy in Ontario community pharmacies
(University of Waterloo, 2019-12-19)Background: Two-thirds of Canadian adults currently do not receive the annual influenza vaccine. Vaccine hesitancy (VH), the voluntary delay or refusal of vaccination services despite availability is a significant contributor ... -
Synthesis and Characterisation of Chiral Nanomaterials and their Influence on Stem Cell Differentiation
(University of Waterloo, 2017-08-11)Tissue engineering is a field related to regenerative medicine which aims at replacing or regenerating a patient’s tissue, usually using a combination of cells and a bioactive material which is designed to influence cell ... -
Transactivation of platelet-derived growth factor receptor type β: Mechanisms and potential relevance in neurobiology
(University of Waterloo, 2013-12-23)In the absence of ligand, certain growth factor receptors can be activated via G protein-coupled receptor (GPCR) activation in a process termed transactivation. Serotonin (5-HT) receptors can transactivate the receptor ... -
Understanding the Relationship Between Pharmacists’ Implicit and Explicit Bias and Perceptions of Pharmacist Services Among Arab and Black Individuals
(University of Waterloo, 2019-11-27)Background. Recent studies suggest that Health Care Professionals’ (HCPs) unconscious bias about race contributes to health care disparities. The objective of this research was to estimate unconscious racial bias among ...