Browsing Pharmacy by Issue Date
Now showing items 1-20 of 132
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Design, Synthesis and Biological Evaluation of 2,4-Disubstituted Pyrimidine Derivatives: Multifunctional Candidates as Potential Treatment Options for Alzheimer’s Disease
(University of Waterloo, 2011-08-30)Alzheimer’s disease (AD) is a highly complex and rapidly progressive neurodegenerative disorder characterized by the systemic collapse of cognitive function and formation of dense amyloid-β (Aβ) plaques and neurofibrillary ... -
Lack of neuroprotective effects by platelet-derived growth factor against beta-amyloid induced toxicity uncovers a novel hypothesis of Alzheimer's disease pathology
(University of Waterloo, 2012-05-18)Aβ oligomer-induced neurotoxicity has become an important area of therapeutic development in treating Alzheimer’s disease. Platelet-derived growth factor (PDGF) has been shown to be able to protect neurons against several ... -
Non-viral gemini surfactant-phospholipid nanoparticles for topical gene delivery to the retina
(University of Waterloo, 2013-01-29)Glaucoma is a group of optic nerve degenerative diseases, which leads to gradual and permanent vision loss. Recent developments in the field of gene therapy have proposed increasingly promising treatments for glaucoma, in ... -
Development of a correlation based and a decision tree based prediction algorithm for tissue to plasma partition coefficients
(University of Waterloo, 2013-04-29)Physiologically based pharmacokinetic (PBPK) modeling is a tool used in drug discovery and human health risk assessment. PBPK models are mathematical representations of the anatomy, physiology and biochemistry of an organism. ... -
Design, Synthesis, and Evaluation of Tacrine-Based Derivatives: Potential Agents to Treat Alzheimer’s Disease
(University of Waterloo, 2013-08-01)With the incidence of Alzheimer’s disease (AD) growing worldwide and in Canada along with the growing economic and social burdens, the need for more effective therapies becomes of great importance. Since the discovery of ... -
Effect of Gemini Surfactants on Amyloid Beta Aggregation
(University of Waterloo, 2013-09-27)Alzheimer’s disease (AD) is a progressive dementia affecting cognition, behavior, and functional status and there is no cure which exists for it. In AD, Amyloid Beta (Aβ) peptides form aggregates that are neurotoxic in the ... -
Construction and Characterization of a Robust in vivo Technology for the Production of Superior DNA Vectors for Gene Therapy and Vaccination
(University of Waterloo, 2013-09-27)Plasmid DNA (pDNA) vectors are the current conventional technology driving therapeutic gene transfer, whether for use toward mal/nonfunctional gene replacement, DNA vaccination, or production of therapeutic proteins in ... -
Transactivation of platelet-derived growth factor receptor type β: Mechanisms and potential relevance in neurobiology
(University of Waterloo, 2013-12-23)In the absence of ligand, certain growth factor receptors can be activated via G protein-coupled receptor (GPCR) activation in a process termed transactivation. Serotonin (5-HT) receptors can transactivate the receptor ... -
Characterization of gemini nanoparticle assembly by fluorescence correlation spectroscopy
(University of Waterloo, 2014-01-23)Research in the field of non-viral gene delivery has demonstrated that a deeper understanding of the fundamental processes of nanoparticle assembly is required in order to improve their efficacy. While gemini nanoparticles ... -
Identifying the mechanism of Aβ42 inhibition of PDGF-BB signalling
(University of Waterloo, 2014-01-23)Alzheimer’s disease is a late-onset neurological disorder characterized by extracellular aggregates of Aβ plaques and neurofibrillary tangles of hyperphosphoryated tau protein resulting in neuronal dysfunction, cognitive ... -
Pluronic-Based Nanoparticles for Gene Therapy Applications
(University of Waterloo, 2014-01-24)Non-viral delivery vectors have potential advantages over the viral systems that currently are used extensively for delivering therapeutic genes of interest. However, non-viral gene therapy has low efficiencies in vivo, ... -
Optimized Production and Purification of LCC DNA Minivectors for Applications in Gene Therapy and Vaccine Development
(University of Waterloo, 2014-01-28)Linear covalently closed (LCC) DNA minivectors serve to be superior to conventional circular covalently closed (CCC) plasmid DNA (pDNA) vectors due to enhancements to both transfection efficiency and safety. Specifically, ... -
Design, construction and characterization of LysK endolysin display phage against Staphylococcus aureus
(University of Waterloo, 2014-02-04)The growing threat of drug- resistant Staphylococcus aureus (S. aureus) infections mandates the need to develop novel, effective and alternative antibacterial therapeutics. Despite infection prevention and control measures, ... -
Identifying signaling differences between GPCR-induced growth factor receptor transactivation and direct ligand activation
(University of Waterloo, 2014-04-01)Growth factor receptors have significant effects on various normal function of body such as cell proliferation, differentiation and apoptosis. They are also involved in neuronal function and dysfunction, cardiovascular ... -
5-HT7 Receptor Neuroprotection against Excitotoxicity in the Hippocampus
(University of Waterloo, 2014-04-11)Introduction and Objectives: The PDGFβ receptor and its ligand, PDGF-BB, are expressed throughout the central nervous system (CNS), including the hippocampas. Several reports confirm that PDGFβ receptors are neuroprotective ... -
Pain Management within the Long-term Care Setting: An Inquiry into Staff-perceived Contemporary Pain Management Practices
(University of Waterloo, 2014-05-06)Background: Chronic pain is a frequent and undertreated ailment within the long-term care community (Herman et al, 2009). The likelihood of experiencing pain increases with age and failure to treat this condition may ... -
Construction and Characterization of a Fine-Tuned Lytic Phage Display System
(University of Waterloo, 2014-08-15)Bacteriophage (phage) Lambda (λ) has played a key historic role in driving our current understanding of molecular genetics. The lytic nature of this bacterial virus along with the conformation of its wild-type capsid protein ... -
Glucopsychosine increases cytosolic calcium to induce calpain-mediated apoptosis of acute myeloid leukemia cells.
(University of Waterloo, 2014-08-20)To identify novel anti-cancer agents, we created and screened a unique nutraceutical library for activity against acute myeloid leukemia (AML) cells. From this screen, we determined that glucopsychosine was selectively ... -
Perceptions of Community-Dwelling Patients on the Impact of the Discontinuation of OxyContin® on their Pain Management: A Mixed Methods Study
(University of Waterloo, 2014-09-02)Chronic pain is considered a major health problem in older adults. OxyContin®, one of the most commonly used medications for treating pain in Canada, was recently discontinued, and delisted from the Ontario Drug Formulary ... -
“I gained a skill and a change in attitude”: A Case Study Describing How an Online Continuing Professional Education Course for Pharmacists Supported Achievement of Its Transfer-to-Practice Outcomes
(The Canadian Association for University Continuing Education, 2014-11-27)The convenience and flexibility of online learning clearly make it an attractive option for learners in professional development contexts. There is less clarity, however, about how it fares as a vehicle for enabling the ...