Browsing Science (Faculty of) by Title
Now showing items 1497-1516 of 3042
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Investigating the Interactions of Fatty Acids, Amyloid Beta & SARS-CoV-2 Spike Protein Fragment
(University of Waterloo, 2023-05-16)There is no cure for Alzheimer’s disease (AD), and the negative implications of having AD were further exacerbated in recent years, as patients with dementia are at the highest risk for mortality upon contracting COVID-19. ... -
Investigating the involvement of FHA domain lateral surfaces in DNA damage and cell cycle checkpoint responses in Saccharomyces cerevisiae
(University of Waterloo, 2023-08-30)Since the discovery of the Forkhead-associated (FHA) domain in 1995, research groups have pursued the characterization of FHA domains and the interactions that they regulate through the lens of their pThr-epitope binding ... -
Investigating the localization and functional significance of adenine phosphoribosyltransferase1 in Arabidopsis chloroplasts
(University of Waterloo, 2014-09-02)Adenine phosphoribosyltransferase (APT) is a housekeeping enzyme that catalyses the principal route of adenine recycling in plants. Of the five APT genes encoded in the Arabidopsis genome, APT1 is the most highly expressed. ... -
Investigating the neuroprotective potential of short-term 5-HT7 receptor activation against neuronal excitotoxicity
(University of Waterloo, 2015-10-05)The pathophysiology of cerebral ischemia or acute ischemic stroke involves what is called neuronal "excitotoxicity", where an initial failure in intracellular energy metabolism causes excessive pre-synaptic glutamate release ... -
Investigating the Outer Envelope Localization of OEP 18 in A. thaliana Chloroplasts
(University of Waterloo, 2021-10-26)Plastids are plant organelles with specialized functions including photosynthesis. The specialized function of each plastid is informed by its distinct and dynamically regulated proteome. The majority of plastid proteins ... -
Investigating the Physicochemical Properties of B12X122− (X = H, F, Cl, Br, I)
(University of Waterloo, 2019-09-24)This thesis focuses on B12X122– (X = H, F, Cl, Br, I) experimentally and computationally to understand the fundamental behaviour of this multiply charged anion (MCA) in the gas and solution phases. The thesis explores three ... -
Investigating the Role of Deoxyhypusine Synthase in the Invasiveness of PC3 Cells Using siRNA
(University of Waterloo, 2008-08-11)Deoxyhypusine synthase (DHS) catalyzes the first step in the hypusination of eukaryotic translation initiation factor 5A (eIF5A). In human cells, two eIF5A isoforms are present, eIF5A-1 and eIF5A-2, and DHS catalyzes the ... -
Investigating the role of the Smoky River watershed on past ice-jam flood regimes at the Peace-Athabasca Delta via analysis of oxbow lake sediment cores
(University of Waterloo, 2022-06-06)The Peace-Athabasca Delta (PAD) in northern Alberta has been a focus of concern for decades due to decline in frequency and magnitude of ice-jam floods that sustain ecologically and culturally significant shallow perched ... -
Investigating the structures and properties of DMS-selected amino acid ions
(University of Waterloo, 2020-11-06)This thesis outlines gas-phase studies of ionized amino acids in which their structures and interactions within ion cluster complexes are probed using mass spectrometry, differential ion mobility, and laser spectroscopy. ... -
Investigating the Use of CRISPR/Cas9 for Genetic Screens in Drosophila
(University of Waterloo, 2021-02-24)The CRISPR/Cas9 system has been adapted into a powerful tool for genetic research. The ability to target regions of a genome in a highly specific manner with a reprogrammable guide RNA has been used in a variety of ... -
Investigating the use of enhancer trapping and Cas9-induced rearrangements to characterize cis-regulatory elements in the Drosophila gene hindsight
(University of Waterloo, 2022-08-22)The gene hindsight (hnt) encodes a transcription factor that is essential for all stages of Drosophila development. Expression of hnt has been observed to promote cell specialization and differentiation of several cell ... -
Investigating the use of variable fluorescence methods to detect phytoplankton nutrient deficiency
(University of Waterloo, 2013-04-29)Variable fluorescence of chlorophyll a (Fv/Fm), measured by pulse amplitude modulated (PAM) fluorometers, is an attractive target for phytoplankton-related water quality management. Lowered Fv/Fm is believed to reflect ... -
Investigating trophic ecology and dietary niche overlap among morphs of Lake Trout in Lake Superior
(University of Waterloo, 2017-01-17)Four morphs of Lake Trout (Salvelinus namaycush, Walbaum 1792) have been identified in Lake Superior: leans, siscowets, humpers, and redfins. In this comprehensive study, the trophic ecology of Lake Trout morphs were ... -
An Investigation and Application of the Finite Difference Time Domain Method as a Tool for Solving Equalization Problems in Acoustics
(University of Waterloo, 2010-01-25)This thesis investigates the issues in deriving the Finite Di erence Time Domain Method, including the derivation of a unique method for exciting an FDTD system that is physically realistic in terms of acoustics. It is ... -
An investigation into marine environments in the eastern Canadian Arctic
(University of Waterloo, 2023-10-20)Arctic marine environments are especially vulnerable to climate change, but detailed scientific data for these ecosystems are lacking due to their remote location and the associated logistical challenges of conducting ... -
An Investigation into the Effect of Increasing Target Size for Visual Sensitivity Measurement in Normals and in Early Glaucoma
(University of Waterloo, 2014-09-02)The clinical standard method of measurement for clinical visual sensitivity is currently Standard Automated Perimetry with a size III target (SAP III). However, there are many factors that can make the results unreliable. ... -
An investigation into the motivations, influences and expectations of students studying optometry in Canada and the United States of America
(University of Waterloo, 2021-04-01)Purpose: To investigate and compare the motivations, influences and expectations of Doctor of Optometry students studying in Canada and the United States of America. Methods: A survey was created, piloted, and conducted ... -
An Investigation into Water Consumption Data Using Parametric Probability Density Functions
(University of Waterloo, 2018-08-07)Many datasets can be expressed through the usage of frequency-based histograms that provide compact visualizations of large volumes of data. A motivating hypothesis of this work is that the relative frequency of measurements ... -
Investigation of Coordination Environments in Heterogeneous Catalysis
(University of Waterloo, 2022-08-25)Increasing energy demand, environmental causes, and sustainable energy goals give rise to the study of energy conversion systems extensively. More efforts have been devoted to oxygen evolution reaction because of kinetic ... -
Investigation of Crystal Structures and Ultra-Low Thermal Conductivities in Novel Group 14 and 15 Chalcogenides
(University of Waterloo, 2023-12-04)The crystal structures and physical properties of several new group 14 and 15 chalcogenides are discussed in this thesis. The thesis discusses the chalcoantimonates TlLa2Sb3Se9 and La12+zSb9-ySe38-z (simplified as La12Sb9Se38). ...