Browsing Science (Faculty of) by Author "Liu, Juewen"
Now showing items 1-20 of 124
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2-Aminopurine-modified DNA homopolymers for robust and sensitive detection of mercury and silver
Zhou, Wenhu; Ding, Jinsong; Liu, Juewen (Elsevier, 2017-01-15)Heavy metal detection is a key topic in analytical chemistry. DNA-based metal recognition has advanced significantly producing many specific metal ligands, such as thymine for Hg2+ and cytosine for Ag+. For practical ... -
Accelerating peroxidase mimicking nanozymes using DNA
Liu, Biwu; Liu, Juewen (Royal Society of Chemistry, 2015-09-07)DNA-capped iron oxide nanoparticles are nearly 10-fold more active as a peroxidase mimic for TMB oxidation than naked nanoparticles. To understand the mechanism, the effect of DNA length and sequence is systematically ... -
Adsorption and Desorption of DNA on Graphene Oxide Studied by Fluorescently Labeled Oligonucleotides
Wu, Marissa; Kempaiah, Ravindra; Huang, Po-Jung Jimmy; Maheshwari, Vivek; Liu, Juewen (American Chemical Society, 2011-03-15)Being the newest member of the carbon materials family, graphene possesses many unique physical properties resulting is a wide range of applications. Recently, it was discovered that graphene oxide can effectively adsorb ... -
Adsorption of DNA Oligonucleotides by Titanium Dioxide Nanoparticles
Zhang, Xu; Wang, Feng; Liu, Biwu; Kelly, Erin Y.; Servos, Mark R.; Liu, Juewen (American Chemical Society, 2014-01-28)Titanium dioxide (TiO2) or titania shows great promise in detoxification and drug delivery. To reach its full potential, it is important to interface TiO2 with biomolecules to harness their molecular recognition function. ... -
Adsorption of DNA onto gold nanoparticles and graphene oxide: surface science and applications
Liu, Juewen (Royal Society of Chemistry, 2012-06-28)The interaction between DNA and inorganic surfaces has attracted intense research interest, as a detailed understanding of adsorption and desorption is required for DNA microarray optimization, biosensor development, and ... -
Adsorption of Nanoceria by Phosphocholine Liposomes
Liu, Yibo; Liu, Juewen (American Chemical Society, 2016-12-13)Nanoceria (CeO2 nanoparticle) possesses a number of enzyme-like activities. In particular, it scavenges reactive oxygen species based on in-vitro and in vivo antioxidation studies. An important aspect of fundamental physical ... -
Amplifying the Macromolecular Crowding Effect Using Nanoparticles
Zaki, Ahmed; Liu, Juewen; Dave, Neeshma (American Chemical Society, 2012-01-11)The melting temperature (Tm) of DNA is affected not only by salt but also by the presence of high molecular weight (MW) solutes, such as polyethylene glycol (PEG), acting as a crowding agent. For short DNAs in a solution ... -
Aptamer-based biosensors for biomedical diagnostics
Zhou, Wenhu; Huang, Po-Jung Jimmy; Ding, Jinsong; Liu, Juewen (Royal Society of Chemistry, 2014-06-07)Aptamers are single-stranded nucleic acids that selectively bind to target molecules. Most aptamers are obtained through a combinatorial biology technique called SELEX. Since aptamers can be isolated to bind to almost any ... -
Aptamer-Functionalized Hydrogel Microparticles for Fast Visual Detection of Mercury(II) and Adenosine
Helwa, Youssef; Dave, Neeshma; Froidevaux, Romain; Samadi, Azadeh; Liu, Juewen (American Chemical Society, 2012-04-25)With a low optical background, high loading capacity, and good biocompatibility, hydrogels are ideal materials for immobilization of biopolymers to develop optical biosensors. We recently immobilized mercury and lead binding ... -
Assembly of DNA-Functionalized Gold Nanoparticles with Gaps and Overhangs in Linker DNA
Smith, Brendan D.; Dave, Neeshma; Huang, Po-Jung Jimmy; Liu, Juewen (American Chemical Society, 2011-04-28)DNA-directed assembly of gold nanoparticles (AuNPs) has been extensively studied because of its important applications in analytical chemistry, materials science, and nanomedicine. In a typical system, two DNA-functionalized ... -
Assembly of DNA-Functionalized Nanoparticles in Alcoholic Solvents Reveals Opposite Thermodynamic and Kinetic Trends for DNA Hybridization
Smith, Brendan D.; Liu, Juewen (American Chemical Society, 2010-05-12)DNA has been a key molecule in biotechnology and nanotechnology. To date, the majority of the experiments involving DNA have been performed in aqueous solutions, which may be related to the perception that DNA hybridization ... -
Attaching DNA to Nanoceria: Regulating Oxidase Activity and Fluorescence Quenching
Pautler, Rachel; Kelly, Erin Y.; Huang, Po-Jung Jimmy; Cao, Jing; Liu, Biwu; Liu, Juewen (American Chemical Society, 2013-08-14)Cerium oxide nanoparticles (nanoceria) have recently emerged as a nanozyme with oxidase activity. In this work, we present a few important interfacial properties of nanoceria. First, the surface charge of nanoceria can be ... -
Biochemical Characterization of a Lanthanide-Dependent DNAzyme with Normal and Phosphorothioate-Modified Substrates
Vazin, Mahsa; Huang, Po-Jung Jimmy; Matuszek, Zaneta; Liu, Juewen (American Chemical Society, 2015-10-06)A trivalent lanthanide (Ln3+)-dependent RNA-cleaving DNAzyme, Ce13d, was recently isolated via in vitro selection. Ce13d is active in the presence of all Ln3+ ions. Via introduction of a single phosphorothioate (PS) ... -
Biomimetic sensing based on chemically induced assembly of a signaling DNA aptamer on a fluid bilayer membrane
Dave, Neeshma; Liu, Juewen (Royal Society of Chemistry, 2012-04-18)The adenosine aptamer was split into two halves and linked to a fluid liposome surface; addition of adenosine resulted in aptamer assembly, which did not occur if the split aptamer was attached to silica nanoparticles, ... -
Blue emitting gold nanoclusters templated by poly-cytosine DNA at low pH and poly-adenine DNA at neutral pH
Kennedy, Thomas A.C.; MacLean, James L.; Liu, Juewen (Royal Society of Chemistry, 2012-07-11)Blue fluorescent gold nanoclusters were prepared in the presence of poly-cytosine DNAs at low pH and poly-adenine at neutral pH using citrate as the reducing agent; various buffer conditions affecting the synthesis have ... -
Boosting the oxidase mimicking activity of nanoceria by fluoride capping: rivaling protein enzymes and ultrasensitive F- detection
Liu, Biwu; Huang, Zhicheng; Liu, Juewen (Royal Society of Chemistry, 2016-07-28)Nanomaterial-based enzyme mimics (nanozymes) are currently a new forefront of chemical research. However, the application of nanozymes is limited by their low catalytic activity and low turnover numbers. Cerium dioxide ... -
Catalytic Nucleic Acids: Biochemistry, Chemical Biology, Biosensors, and Nanotechnology
Ma, Lingzi; Liu, Juewen (Elsevier, 2020-01)Since the initial discovery of ribozymes in the early 1980s, catalytic nucleic acids have been used in different areas. Compared with protein enzymes, catalytic nucleic acids are programmable in structure, easy to modify, ... -
Cation-Size-Dependent DNA Adsorption Kinetics and Packing Density on Gold Nanoparticles: An Opposite Trend
Liu, Biwu; Kelly, Erin Y.; Liu, Juewen (American Chemical Society, 2014-11-11)The property of DNA is strongly influenced by counterions. Packing a dense layer of DNA onto a gold nanoparticle (AuNP) generates an interesting colloidal system with many novel physical properties such as a sharp melting ... -
Characterization of glucose oxidation by gold nanoparticles using nanoceria
Lang, Nathan J.; Liu, Biwu; Liu, Juewen (Elsevier, 2014-04-30)Gold nanoparticles (AuNPs) can oxidize glucose, producing hydrogen peroxide and gluconic acid, which are the same products as those generated by glucose oxidase (GOx). In this regard, AuNPs are a nanozyme. Herein, a new ... -
Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine
Wang, Feng; Huang, Po-Jung Jimmy; Liu, Juewen (Royal Society of Chemistry, 2013-10-21)The reaction between cisplatin and DNA is conveniently studied using fluorescently labeled oligonucleotides and gel electrophoresis; as an example of application, the inhibition of this reaction by citrate is demonstrated, ...