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Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine

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Liu_Juewen(20).pdf (573.09 KB)

Date

2013-10-21

Authors

Wang, Feng
Huang, Po-Jung Jimmy
Liu, Juewen

Journal Title

Journal ISSN

Volume Title

Publisher

Royal Society of Chemistry

Abstract

The reaction between cisplatin and DNA is conveniently studied using fluorescently labeled oligonucleotides and gel electrophoresis; as an example of application, the inhibition of this reaction by citrate is demonstrated, which might increase selectivity of cisplatin towards guanine over adenine.

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Keywords

DNA, citrate, fluorescence

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Citation

URI

http://dx.doi.org/10.1039/C3CC45458D
 http://hdl.handle.net/10012/11397

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Waterloo Research
Chemistry
Waterloo Institute for Nanotechnology