Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine
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Date
2013-10-21
Authors
Wang, Feng
Huang, Po-Jung Jimmy
Liu, Juewen
Advisor
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
The reaction between cisplatin and DNA is conveniently studied using fluorescently labeled oligonucleotides and gel electrophoresis; as an example of application, the inhibition of this reaction by citrate is demonstrated, which might increase selectivity of cisplatin towards guanine over adenine.
Description
Keywords
DNA, citrate, fluorescence