Browsing Pharmacy by Subject "Pharmacy"
Now showing items 21-34 of 34
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Isolation and Characterization of Host Mutations that Suppress the Bacteriophage Lambda (λ) Rex Phenotype
(University of Waterloo, 2015-09-01)The Bacteriophage lambda (λ) T4rII exclusion (Rex) phenotype is defined as the inability of T4rII mutant bacteriophage to form plaques on a lawn of E. coli lysogenized by bacteriophage λ. More than six decades have passed ... -
Lack of neuroprotective effects by platelet-derived growth factor against beta-amyloid induced toxicity uncovers a novel hypothesis of Alzheimer's disease pathology
(University of Waterloo, 2012-05-18)Aβ oligomer-induced neurotoxicity has become an important area of therapeutic development in treating Alzheimer’s disease. Platelet-derived growth factor (PDGF) has been shown to be able to protect neurons against several ... -
Langmuir-Blodgett Monolayer Studies of Mixed Gemini Surfactant-Phospholipid Monolayers system for Gene Therapy Applications.
(University of Waterloo, 2015-10-23)Gene delivery relies upon the encapsulation of a gene of interest, which is then ideally delivered to target cells. For gene therapy applications, viral vectors are the most efficient vectors currently being studied, ... -
Metabolism, transport, and physiologically based pharmacokinetic modelling of novel tacrine derivatives
(University of Waterloo, 2015-08-26)Alzheimer’s disease (AD) is the most prevalent form of dementia affecting the elderly population, and its burden is rapidly growing both in Canada and worldwide. As a result, there is a substantial need for more effective ... -
Mobile Technology and Health Literacy Regarding Medication Information
(University of Waterloo, 2015-10-05)Low health literacy is one of the main barriers to medication adherence. People with low literacy often have difficulty understanding health information and making appropriate health decisions. Currently, medication ... -
Non-viral gemini surfactant-phospholipid nanoparticles for topical gene delivery to the retina
(University of Waterloo, 2013-01-29)Glaucoma is a group of optic nerve degenerative diseases, which leads to gradual and permanent vision loss. Recent developments in the field of gene therapy have proposed increasingly promising treatments for glaucoma, in ... -
Optimized Production and Purification of LCC DNA Minivectors for Applications in Gene Therapy and Vaccine Development
(University of Waterloo, 2014-01-28)Linear covalently closed (LCC) DNA minivectors serve to be superior to conventional circular covalently closed (CCC) plasmid DNA (pDNA) vectors due to enhancements to both transfection efficiency and safety. Specifically, ... -
Pain Management within the Long-term Care Setting: An Inquiry into Staff-perceived Contemporary Pain Management Practices
(University of Waterloo, 2014-05-06)Background: Chronic pain is a frequent and undertreated ailment within the long-term care community (Herman et al, 2009). The likelihood of experiencing pain increases with age and failure to treat this condition may ... -
Perceptions of Community-Dwelling Patients on the Impact of the Discontinuation of OxyContin® on their Pain Management: A Mixed Methods Study
(University of Waterloo, 2014-09-02)Chronic pain is considered a major health problem in older adults. OxyContin®, one of the most commonly used medications for treating pain in Canada, was recently discontinued, and delisted from the Ontario Drug Formulary ... -
Pluronic-Based Nanoparticles for Gene Therapy Applications
(University of Waterloo, 2014-01-24)Non-viral delivery vectors have potential advantages over the viral systems that currently are used extensively for delivering therapeutic genes of interest. However, non-viral gene therapy has low efficiencies in vivo, ... -
Prevalence of Potentially Inappropriate Medications Use Among Recently Admitted Geriatric Patients in Rural Hospitals
(University of Waterloo, 2014-12-11)Potentially inappropriate medications (PIMs) are prescribed most often to elderly patients and can cause serious adverse effects. Older adults tend to use multiple medications, and age-related physiological changes can ... -
Shades of gray in vaccine decision making: Understanding, exploring, and addressing the challenges of influenza vaccine hesitancy in Ontario community pharmacies
(University of Waterloo, 2019-12-19)Background: Two-thirds of Canadian adults currently do not receive the annual influenza vaccine. Vaccine hesitancy (VH), the voluntary delay or refusal of vaccination services despite availability is a significant contributor ... -
Synthesis of Multiply Deuterated Cephalosporins
(University of Waterloo, 2014-12-12)Antibiotics are one of the greatest accomplishments in the field of science. They have been extensively used since the time of their discovery. Amongst all the antibiotics, the -lactam class of antibiotics have been the ... -
Transactivation of platelet-derived growth factor receptor type β: Mechanisms and potential relevance in neurobiology
(University of Waterloo, 2013-12-23)In the absence of ligand, certain growth factor receptors can be activated via G protein-coupled receptor (GPCR) activation in a process termed transactivation. Serotonin (5-HT) receptors can transactivate the receptor ...