Browsing Science (Faculty of) by Author "Liu, Juewen"
Now showing items 21-40 of 124
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A Cleavable Molecular Beacon for Hg2+ Detection based on Phosphorothioate RNA Modifications
Huang, Po-Jung Jimmy; Wang, Feng; Liu, Juewen (American Chemical Society, 2015-06-10)Mercury is a highly toxic heavy metal, and detection of Hg2+ by biosensors has attracted extensive research interest in the past decade. In particular, a number of DNA-based sensing strategies have been developed. Well-known ... -
Co-immobilization of multiple enzymes by metal coordinated nucleotide hydrogel nanofibers: improved stability and an enzyme cascade for glucose detection
Liang, Hao; Jiang, Shuhui; Yuan, Qipeng; Li, Guofeng; Wang, Feng; Zhang, Zijie; Liu, Juewen (Royal Society of Chemistry, 2016-03-21)Preserving enzyme activity and promoting synergistic activity via co-localization of multiple enzymes are key topics in bionanotechnology, materials science, and analytical chemistry. This study reports a facile method for ... -
Comparison of Graphene Oxide and Reduced Graphene Oxide for DNA Adsorption and Sensing
Lu, Chang; Huang, Po-Jung Jimmy; Liu, Biwu; Ying, Yibin; Liu, Juewen (American Chemical Society, 2016-10-18)Fluorescently labeled DNA adsorbed on graphene oxide (GO) is a well-established sensing platform for detecting a diverse range of analytes. GO is a loosely defined material and its oxygen content may vary depending on the ... -
Comparison of MoS2, WS2, and Graphene Oxide for DNA Adsorption and Sensing
Lu, Chang; Liu, Yibo; Ying, Yibin; Liu, Juewen (American Chemical Society, 2017-01-17)Interfacing DNA with two-dimensional (2D) materials has been intensely researched for various analytical and biomedical applications. Most of these studies have been performed on graphene oxide (GO) and two metal ... -
A Comprehensive Screen of Metal Oxide Nanoparticles for DNA Adsorption, Fluorescence Quenching, and Anion Discrimination
Liu, Biwu; Liu, Juewen (American Chemical Society, 2015-10-22)Although DNA has been quite successful in metal cation detection, anion detectioin remains challenging because of the charge repulsion. Metal oxides represent a very important class of materials, and different oxides might ... -
Correlation of photobleaching, oxidation and metal induced fluorescence quenching of DNA-templated silver nanoclusters
Morishita, Kiyoshi; MacLean, James L.; Liu, Biwu; Jiang, Hui; Liu, Juewen (Royal Society of Chemistry, 2013-04-07)Few-atom noble metal nanoclusters have attracted a lot of interest due to their potential applications in biosensor development, imaging and catalysis. DNA-templated silver nanoclusters (AgNCs) are of particular interest ... -
Covalent linking DNA to graphene oxide and its comparison with physisorbed probes for Hg2+ detection
Lu, Chang; Huang, Po-Jung Jimmy; Ying, Yibin; Liu, Juewen (Elsevier, 2016-05-15)Graphene oxide (GO) has attracted extensive research interest as a platform for DNA adsorption and biosensor development. While most researchers use simple physisorption of fluorescently labeled DNA, covalent sensors are ... -
Cr3+ Binding to DNA Backbone Phosphate and Bases: Slow Ligand Exchange Rates and Metal Hydrolysis
Zhou, Wenhu; Yu, Tianmeng; Vazin, Mahsa; Ding, Jinsong; Liu, Juewen (American Chemical Society, 2017-06-07)The interaction between chromium ions and DNA is of great interest in inorganic chemistry, toxicology, and analytical chemistry. Most previous studies focused on in situ reduction of Cr(VI), producing Cr3+ for DNA binding. ... -
Degradable starch nanoparticle assisted ethanol precipitation of DNA
Ip, Alexander C-F.; Tsai, Tsung Hao; Khimji, Imran; Huang, Po-Jung Jimmy; Liu, Juewen (Elsevier, 2014-04-18)Precipitation of DNA from a large volume of aqueous solution is an important step in many molecular biology and analytical chemistry experiments. Currently, this is mainly achieved by ethanol precipitation, where a long-term ... -
Desulfurization Activated Phosphorothioate DNAzyme for the Detection of Thallium
Huang, Po-Jung Jimmy; Vazin, Mahsa; Liu, Juewen (American Chemical Society, 2015-10-20)Thallium (Tl) is a highly toxic heavy metal situated between mercury and lead in the periodic table. While its neighbors have been thoroughly studied for DNA-based sensing, little is known about thallium detection. In this ... -
Dissecting Colloidal Stabilization Factors in Crowded Polymer Solutions by Forming Self-Assembled Monolayers on Gold Nanoparticles
Lang, Nathan J.; Liu, Biwu; Zhang, Xu; Liu, Juewen (American Chemical Society, 2013-05-21)An ideal colloidal system should be highly stable in a diverse range of buffer conditions while still retaining its surface accessibility. We recently reported that dispersing citrate-capped gold nanoparticles (AuNPs) in ... -
Dissecting the effect of anions on Hg2+ detection using a FRET based DNA probe
Kiy, Mehmet Murat; Zaki, Ahmed; Menhaj, Arsalsan Beg; Samadi, Azadeh; Liu, Juewen (Royal Society of Chemistry, 2012-08-07)Many biosensors have been developed to detect Hg2+ using thymine-rich DNA. While sensor response to various cations is often studied to demonstrate selectivity, the effect of anions has been largely overlooked. Anions may ... -
Dissociation and Degradation of Thiol-Modified DNA on Gold Nanoparticles in Aqueous and Organic Solvents
Bhatt, Nishi; Huang, Po-Jung Jimmy; Dave, Neeshma; Liu, Juewen (American Chemical Society, 2011-05-17)Gold nanoparticles functionalized with thiol-modified DNA have been widely used in making various nanostructures, colorimetric biosensors, and drug delivery vehicles. Over the past 15 years, significant progress has been ... -
Distinction of Individual Lanthanide Ions with a DNAzyme Beacon Array
Huang, Po-Jung Jimmy; Vazin, Mahsa; Lin, Jennifer J.; Pautler, Rachel; Liu, Juewen (American Chemical Society, 2016-06-24)Developing chemical probes to distinguish each lanthanide ion is a long-standing challenge. Aside from its analytical applications, solving this problem will also enhance our knowledge in metal ligand design. Using in vitro ... -
DNA Adsorption by Indium Tin Oxide (ITO) Nanoparticles
Liu, Biwu; Liu, Juewen (American Chemical Society, 2015-01-13)The high conductivity and optical transparency of indium tin oxide (ITO) has made it a popular material in the electronic industry. Recently, its application in biosensors is also explored. To understand its biointerface ... -
DNA adsorption by magnetic iron oxide nanoparticles and its application for arsenate detection
Liu, Biwu; Liu, Juewen (Royal Society of Chemistry, 2014-05-01)Iron oxide nanoparticles adsorb fluorescently labeled DNA oligonucleotides via the backbone phosphate and quench fluorescence. Arsenate displaces adsorbed DNA to increase fluorescence, allowing detection of arsenate down ... -
DNA Adsorption by ZnO Nanoparticles near Its Solubility Limit: Implications for DNA Fluorescence Quenching and DNAzyme Activity Assays
Ma, Lingzi; Liu, Biwu; Huang, Po-Jung Jimmy; Zhang, Xu; Liu, Juewen (American Chemical Society, 2016-06-07)Zinc oxide (ZnO) is a highly important material, and Zn2+ is a key metal ion in biology. ZnO and Zn2+ interconvert via dissolution and hydrolysis/condensation. In this work, we explore their interactions with DNA, which ... -
DNA duplex stabilization in crowded polyanion solutions
Khimji, Imran; Shin, Jeehae; Liu, Juewen (Royal Society of Chemistry, 2013-02-14)The melting temperature of duplex DNA is much higher in polyanions than in non-ionic polymers with similar ionic strength, suggesting an additional electrostatic contribution on top of the excluded volume effect. -
DNA stabilized fluorescent metal nanoclusters for biosensor development
Liu, Juewen (Elsevier, 2014-03-22)Fluorescent silver, gold and copper nanoclusters (NCs) have emerged for biosensor development. Compared to semiconductor quantum dots, there is less concern about the toxicity of metal NCs, which can be more easily conjugated ... -
DNA stabilized silver nanoclusters for ratiometric and visual detection of Hg2+ and its immobilization in hydrogels
MacLean, James L.; Morishita, Kiyoshi; Liu, Juewen (Elsevier, 2013-04-11)DNA oligomers are particularly interesting templates for making silver nanoclusters (AgNCs) as different emission colors can be obtained by varying the DNA sequence. Many AgNCs have been used as Hg2+ sensors since Hg2+ ...