Browsing Theses by Subject "siRNA"
Now showing items 1-7 of 7
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Design, Characterization and Application of Amphipathic Peptides for siRNA Delivery
(University of Waterloo, 2013-01-25)Short interfering RNAs (siRNAs) are 21-23 nucleotide-long double-stranded RNA molecules that can trigger the RNA interference (RNAi). RNAi is a post-transcriptional gene silencing process whereby siRNAs induce the ... -
Development and characterization of stimuli-responsive drug delivery systems to prevent HIV infection and the treatment of chronic wounds
(University of Waterloo, 2021-06-10)Patient compliance is very important and highly depends on the drug dosage form which correlates with the success of therapy. Drug delivery systems can be adapted to different pharmaceutical ingredients and to different ... -
Endosomolytic arginine-rich peptides for therapeutic siRNA delivery
(University of Waterloo, 2014-07-23)At the forefront of revolutionizing medicine, gene therapy provides an effective way to treat a range of diseases by regulating defective genes at the root of the disease. Short interfering RNA (siRNA) holds great promise ... -
Investigating the Role of Deoxyhypusine Synthase in the Invasiveness of PC3 Cells Using siRNA
(University of Waterloo, 2008-08-11)Deoxyhypusine synthase (DHS) catalyzes the first step in the hypusination of eukaryotic translation initiation factor 5A (eIF5A). In human cells, two eIF5A isoforms are present, eIF5A-1 and eIF5A-2, and DHS catalyzes the ... -
Matrix Metalloproteinase-2 Cleavable Peptide-Based siRNA Delivery System for Cancer Treatment
(University of Waterloo, 2019-09-23)Among all kinds of gene therapy, siRNA, a class of 20 to 25 nucleotide-long double-stranded RNA molecules, is one of the promising therapeutic solutions to regulate post-transcriptional process for cancer treatment. However, ... -
Peptide Mediated siRNA Delivery: Physicochemical and in vitro Characterizations
(University of Waterloo, 2008-01-22)Short interfering RNAs (siRNAs) trigger RNA interference (RNAi) both in vitro and in vivo, where the expression of the encoded protein is silenced. Its potential use as a therapeutic agent is limited by its rapid enzymatic ... -
Stearylated Peptides for Therapeutic siRNA Delivery and Their Cellular Uptake Mechanisms
(University of Waterloo, 2015-10-15)Small interfering RNA (siRNA) shows great potential as a powerful tool in gene therapy, due to its ability to regulate gene expression in a highly selective manner. siRNA is a double-stranded RNA consisting of 21–23 ...