Browsing Theses by Subject "NMR"
Now showing items 1-20 of 20
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1H MAS NMR Study of Water on Pd-MCM-41
(University of Waterloo, 2015-06-18)Hydrogen spillover represents one of the most promising avenues to achieve hydrogen storage at the density required for transportation applications. The spillover phenomenon, however, is a topic of much debate, with many ... -
Above Bandgap Hyperpolarization Mechanism in Isotopically Purified Silicon and Optimal Bayesian Experiment Design for $T_1$ Estimation
(University of Waterloo, 2018-05-24)This thesis is concerned with the mechanism underlying the above bandgap illumination Dynamic Nuclear Polarization (DNP) of phosphorus donors in isotopically purified silicon-28. Two proposed DNP models are introduced and ... -
Action Mechanism and Structural Studies on the Lipopeptide Antibiotic Daptomycin
(University of Waterloo, 2019-07-02)Daptomycin (dap) is calcium-dependent lipopeptide antibiotic that is used clinically to treat systemic infections caused by Gram-positive pathogens. It is thought that dap brings about its antimicrobial effect by binding ... -
Characterization and Control in Large Hilbert spaces.
(University of Waterloo, 2008-12-03)Computational devices built on and exploiting quantum phenomena have the potential to revolutionize our understanding of computational complexity by being able to solve certain problems faster than the best known classical ... -
Coherent control of nuclear and electron spins for quantum information processing
(University of Waterloo, 2015-08-10)The ability to perform quantum error correction (QEC) arbitrarily many cycles is a significant challenge for scalable quantum information processing (QIP). Key requirements for multiple-round QEC are a high degree of quantum ... -
Determining relaxation times for porous media: Theory, measurement, and the inverse problem
(University of Waterloo, 2007-08-03)This thesis provides an introduction to and analysis of the problem of determining nuclear magnetic resonance (NMR) relaxation times of porous media by using the so-called Carr-Purcell-Meiboom-Gill (CPMG) technique. We ... -
Development of a Serum-Free Chemically Defined Medium for Adherent and Suspension Culture
(University of Waterloo, 2022-01-07)The development of suspension cell lines is a sought after holy grail for bioprocess development. Suspension cell lines allow for easier scale up and better volumetric productivity for most biotherapeutics, including vaccine ... -
Fast and Robust Mathematical Modeling of NMR Assignment Problems
(University of Waterloo, 2012-04-26)NMR spectroscopy is not only for protein structure determination, but also for drug screening and studies of dynamics and interactions. In both cases, one of the main bottleneck steps is backbone assignment. When a homologous ... -
From Metabolite Concentration to Flux – A Systematic Assessment of Error in Cell Culture Metabolomics
(University of Waterloo, 2016-08-05)The growing availability of genomic, transcriptomic, and metabolomic data has opened the door to the synthesis of multiple levels of information in biological research. As a consequence, there has been a push to analyze ... -
¹H MAS NMR Spectral Coalescence of Water and Hydroxyl Resonances in MCM-41
(University of Waterloo, 2011-09-01)Solid state ¹H MAS NMR spectroscopy was used to investigate the temperature and hydration dependance of water and hydroxyl proton spectra of hydrated mesoporous MCM-41. The NMR spectra show a complex peak structure, with ... -
Investigation of Immature Cu,Zn Superoxide Dismutase 1 Using Variable Temperature NMR
(University of Waterloo, 2020-09-03)Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disease that results in the death of motor neurons in the spinal cord, cortex, and brain stem. The vast majority of ALS cases arise sporadically, but ... -
Metabolomic Profiling of Nutrient Solutions for Characterization of Human Gut Microbiota
(University of Waterloo, 2015-01-06)Studying the metabolite output, the “exometabolome,” of bacterial communities provides insight into the metabolic interactions occurring within that ecosystem. As such, a metabolomic approach can be used to gain further ... -
NMR STUDY OF EXCHANGE AND HYDRATION SITE IDENTIFICATION IN MCM-41
(University of Waterloo, 2007-01-16)Deuteron 1D and 2D NMR spectroscopy was used to study the dynamics of water molecules within the mesoporous material MCM-41. The deuteron spectra show three magnetization components for a sample hydrated to a 0.2 monolayer ... -
On Experimental Deterministic Quantum Computation with One Quantum Bit (DQC1)
(University of Waterloo, 2012-03-27)Quantum information processors have the ability to drastically change our world. By manipulating bits of information ruled by the laws of quantum mechanics, computational devices can perform some computations that are ... -
On single-crystal solid-state NMR based quantum information processing
(University of Waterloo, 2010-05-19)Quantum information processing devices promise to solve some problems more efficiently than their classical counterparts. The source of the speedup is the structure of quantum theory itself. In that sense, the physical ... -
An Optimizing Pulse Sequence Compiler for NMR QIP
(University of Waterloo, 2003)Quantum information processing is a multi-disciplinary science involving physics, mathematics, computer science, and even quantum chemistry. It is centred around the idea of manipulating physical systems at the quantum ... -
Origin of NMR Spectral Features in MCM-41 at Low Hydrations
(University of Waterloo, 2010-09-01)Although extensive literature exists on NMR of water in MCM-41, the origin of a number of NMR spectral features in this material had not been understood. Specifically, the OH proton resonance observed in the dry material ... -
Polypropylene Modified by Polydimethylsiloxane in Catalytic Cross Metathesis Reactions
(University of Waterloo, 2010-07-09)In this study, we were particularly interested in looking at the possibility that cross metathesis of olefins in melt phase could be used to produce polydimethylsiloxane (PDMS) modified polypropylene (PP). The intention ... -
Supplementation Strategies for Tuning Glycosylation of Monoclonal Antibodies and Enhancing Growth in Mammalian Cell Culture by Omics Analysis
(University of Waterloo, 2018-04-17)Two fundamental objectives of bioprocess engineering are to increase productivity and improve product quality. Glycosylation is a critical and variable factor in the quality of several therapeutic proteins, particularly ... -
Towards Automating Protein Structure Determination from NMR Data
(University of Waterloo, 2009-09-29)Nuclear magnetic resonance (NMR) spectroscopy technique is becoming exceedingly significant due to its capability of studying protein structures in solution. However, NMR protein structure determination has remained a ...