Browsing Theses by Subject "Apoptosis"
Now showing items 1-10 of 10
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Dynamic Modeling of Apoptosis and its Interaction with Cell Growth in Mammalian Cell Culture
(University of Waterloo, 2012-01-20)In order to optimize productivity of a cell culture it is necessary to understand growth and productivity and couple these features of the culture to extracellular nutrients whose profiles can be manipulated. Also, since ... -
Effects of Dietary Bovine Lactoferrin on Intestinal Lymphocytes of Mice After Dextran Sulfate Sodium or Acute Exercise Challenge
(University of Waterloo, 2008-11-04)Background: Inflammation, if uncontrolled, can promote the formation of colon cancer. Intestinal lymphocytes (IL) are immune cells that can participate in inflammation through the generation of cytokines and by causing ... -
Examining the Role of Autophagy in Skeletal Muscle Cell Death and Differentiation
(University of Waterloo, 2015-01-08)Autophagy is catabolic process which sequesters large portions of cytoplasm as well as selected organelles and proteins for degradation. Recently, autophagy has been a topic of much debate owing to conflicting evidence ... -
The Genetic Analysis of Autophagy-Dependent Caspase Activation in Drosophila melanogaster
(University of Waterloo, 2009-10-23)During Drosophila melanogaster pupation, groups of undifferentiated adult cells proliferate and undergo regulated cell shape changes, while larval tissues are eliminated by programmed cell death (PCD). PCD is most commonly ... -
Interplay between Autophagy and Apoptosis During Skeletal Muscle Differentiation
(University of Waterloo, 2020-07-07)Our previous studies showed that autophagy regulates apoptosis and is required for proper skeletal muscle differentiation. Previously, we inhibited autophagy in C2C12 cells using 3MA (3-methyladenine) treatment or shRNA ... -
Investigating The Impact of Multipurpose Solutions Released From Silicone Hydrogel Lenses on Corneal Epithelial Cells, in vitro
(University of Waterloo, 2010-01-22)Cytotoxicity of Multi-Purpose Solutions (MPS) is commonly tested on cells using diluted MPS or extracts from MPS soaked contact lenses. There is evidence that lens type will affect uptake and release of compounds contained ... -
Modeling of Cancer Signaling Pathways
(University of Waterloo, 2013-09-13)Cancer is an ongoing problem all over the world. To find a cure to this disease, both clinicians and scientists are looking for a reasonable treatment method. According to Hanahan and Weinberg, one of the hallmarks of ... -
Morphological and Apoptotic Alterations in Skeletal Muscle of Mice Deficient in Apoptosis Repressor with Caspase Recruitment Domain
(University of Waterloo, 2012-01-05)Altered apoptotic signaling in skeletal muscle has been observed in a number of disease states associated with skeletal muscle atrophy. Therefore, understanding the mechanisms that lead to increased skeletal muscle apoptosis ... -
An Obese Genotype Affects Apoptosis Related Gene Expression
(University of Waterloo, 2009-01-15)Apoptosis is a genetically regulated form of cell death that occurs when the cell is exposed to physiological, pathogenic, or cytotoxic stimuli. Unregulated apoptosis (too much or too little apoptosis) at any time from ... -
The Role of Apoptosis Repressor with Caspase Recruitment Domain in Aging Mouse Skeletal Muscle Morphology and Apoptotic Signaling
(University of Waterloo, 2015-01-23)Abstract Aging is associated with a loss of skeletal muscle mass, known as sarcopenia, which results in numerous degenerative alterations and decreased strength. One of the major mechanisms influencing muscle wasting in ...