Browsing Theses by Title
Now showing items 7897-7916 of 15573
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Investigating the influence of the transcription factor Hindsight in a Notch-induced tumour model
(University of Waterloo, 2023-01-24)In Drosophila development, the adult salivary gland and hindgut are derived from populations of undifferentiated cells that are found in the larval stages and are known as the salivary gland imaginal ring (SGIR) and hindgut ... -
Investigating the Influences of Tree Coverage and Road Network Density on Property Crime: A Case Study in the City of Vancouver, British Columbia, Canada
(University of Waterloo, 2016-05-18)With the development of Geographic Information Systems (GIS), crime mapping becomes an effective approach to investigate the spatial pattern of crime in a defined area. Understanding the relationship between crime and its ... -
Investigating the Interactions of Fatty Acids, Amyloid Beta & SARS-CoV-2 Spike Protein Fragment
(University of Waterloo, 2023-05-16)There is no cure for Alzheimer’s disease (AD), and the negative implications of having AD were further exacerbated in recent years, as patients with dementia are at the highest risk for mortality upon contracting COVID-19. ... -
Investigating the involvement of FHA domain lateral surfaces in DNA damage and cell cycle checkpoint responses in Saccharomyces cerevisiae
(University of Waterloo, 2023-08-30)Since the discovery of the Forkhead-associated (FHA) domain in 1995, research groups have pursued the characterization of FHA domains and the interactions that they regulate through the lens of their pThr-epitope binding ... -
Investigating the localization and functional significance of adenine phosphoribosyltransferase1 in Arabidopsis chloroplasts
(University of Waterloo, 2014-09-02)Adenine phosphoribosyltransferase (APT) is a housekeeping enzyme that catalyses the principal route of adenine recycling in plants. Of the five APT genes encoded in the Arabidopsis genome, APT1 is the most highly expressed. ... -
Investigating the Location Pattern of Information and Communication Technology Firms: Case of Vancouver
(University of Waterloo, 2012-01-24)Despite the volume of literature examining the role of producer amenities (e.g., highways and airports) in firms’ selection of a location, almost no quantitative studies regard the impact of consumer amenities (e.g., ... -
Investigating the long-term effects of concussion on sensory gating
(University of Waterloo, 2018-01-08)The prefrontal cortex (PFC) is a brain region critical for an abundance of neural processes. A vast amount of research employing both behavioural and neurophysiological methods has demonstrated significant impairments in ... -
Investigating the neuroprotective potential of short-term 5-HT7 receptor activation against neuronal excitotoxicity
(University of Waterloo, 2015-10-05)The pathophysiology of cerebral ischemia or acute ischemic stroke involves what is called neuronal "excitotoxicity", where an initial failure in intracellular energy metabolism causes excessive pre-synaptic glutamate release ... -
Investigating the Outer Envelope Localization of OEP 18 in A. thaliana Chloroplasts
(University of Waterloo, 2021-10-26)Plastids are plant organelles with specialized functions including photosynthesis. The specialized function of each plastid is informed by its distinct and dynamically regulated proteome. The majority of plastid proteins ... -
Investigating the Physicochemical Properties of B12X122− (X = H, F, Cl, Br, I)
(University of Waterloo, 2019-09-24)This thesis focuses on B12X122– (X = H, F, Cl, Br, I) experimentally and computationally to understand the fundamental behaviour of this multiply charged anion (MCA) in the gas and solution phases. The thesis explores three ... -
Investigating the Process of Developing a KDD Model for the Classification of Cases with Cardiovascular Disease Based on a Canadian Database
(University of Waterloo, 2013-01-10)Medicine and health domains are information intensive fields as data volume has been increasing constantly from them. In order to make full use of the data, the technique of Knowledge Discovery in Databases (KDD) has ... -
Investigating the relation between boredom and media multitasking
(University of Waterloo, 2020-09-09)Media multitasking entails simultaneously engaging in multiple tasks when at least one of the tasks is based in media. Despite the abundance of research devoted to understanding the antecedents of media multitasking, little ... -
Investigating the Relationship between Householders’ Engagement with Feedback and Electricity Consumption: An Ontario, Canada Case-Study
(University of Waterloo, 2014-01-22)In this study, 22 homes in Milton, Ontario had their electricity consumption monitored for between seven and 15 months, and they were provided access to their data via an online webportal. The webportal provided appliance-level ... -
Investigating the Role of Deoxyhypusine Synthase in the Invasiveness of PC3 Cells Using siRNA
(University of Waterloo, 2008-08-11)Deoxyhypusine synthase (DHS) catalyzes the first step in the hypusination of eukaryotic translation initiation factor 5A (eIF5A). In human cells, two eIF5A isoforms are present, eIF5A-1 and eIF5A-2, and DHS catalyzes the ... -
Investigating the Role of Intergroup Contact within an Inner-City Youth Sport-for-Development Program: A Case Study
(University of Waterloo, 2018-05-04)Sport is often viewed as having a positive impact on shaping both individual and community development. Sport, used for such developmental purposes, is commonly referred to as sport-for-development (SFD). A common goal of ... -
Investigating the role of task intensity on motor unit fatigue recovery
(University of Waterloo, 2023-01-05)Background: It is unclear how the intensity as well as the underlying contributions of larger versus smaller motor units of a performed task impacts fatigue recovery. Therefore, I tested two hypotheses: that the normalized ... -
Investigating the role of the Smoky River watershed on past ice-jam flood regimes at the Peace-Athabasca Delta via analysis of oxbow lake sediment cores
(University of Waterloo, 2022-06-06)The Peace-Athabasca Delta (PAD) in northern Alberta has been a focus of concern for decades due to decline in frequency and magnitude of ice-jam floods that sustain ecologically and culturally significant shallow perched ... -
Investigating the Role of Water Quality on the Galvanic Corrosion of Lead in Hard Drinking Water with a Focus on NOM
(University of Waterloo, 2020-05-25)Although the use of lead in water distribution systems is currently prohibited in Canada, old lead service lines, lead solder, and lead containing plumbing fixtures continue to be sources of lead in the tap water of many ... -
Investigating the Spatial Patterns of Income Inequality and Crime: Applications of Spatiotemporal Data Analysis Techniques
(University of Waterloo, 2021-10-25)Income inequality and crime are two social problems concerning many nations around the world. Such social issues can have detrimental effects on society and are interconnected, meaning that high crime rates may be associated ... -
Investigating the structures and properties of DMS-selected amino acid ions
(University of Waterloo, 2020-11-06)This thesis outlines gas-phase studies of ionized amino acids in which their structures and interactions within ion cluster complexes are probed using mass spectrometry, differential ion mobility, and laser spectroscopy. ...