Browsing University of Waterloo by Author "Dave, Neeshma"
Now showing items 1-14 of 14
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Amplifying the Macromolecular Crowding Effect Using Nanoparticles
Zaki, Ahmed; Liu, Juewen; Dave, Neeshma (American Chemical Society, 2012-01-11)The melting temperature (Tm) of DNA is affected not only by salt but also by the presence of high molecular weight (MW) solutes, such as polyethylene glycol (PEG), acting as a crowding agent. For short DNAs in a solution ... -
Aptamer-Functionalized Hydrogel Microparticles for Fast Visual Detection of Mercury(II) and Adenosine
Helwa, Youssef; Dave, Neeshma; Froidevaux, Romain; Samadi, Azadeh; Liu, Juewen (American Chemical Society, 2012-04-25)With a low optical background, high loading capacity, and good biocompatibility, hydrogels are ideal materials for immobilization of biopolymers to develop optical biosensors. We recently immobilized mercury and lead binding ... -
Assembly of DNA-Functionalized Gold Nanoparticles with Gaps and Overhangs in Linker DNA
Smith, Brendan D.; Dave, Neeshma; Huang, Po-Jung Jimmy; Liu, Juewen (American Chemical Society, 2011-04-28)DNA-directed assembly of gold nanoparticles (AuNPs) has been extensively studied because of its important applications in analytical chemistry, materials science, and nanomedicine. In a typical system, two DNA-functionalized ... -
Biomimetic sensing based on chemically induced assembly of a signaling DNA aptamer on a fluid bilayer membrane
Dave, Neeshma; Liu, Juewen (Royal Society of Chemistry, 2012-04-18)The adenosine aptamer was split into two halves and linked to a fluid liposome surface; addition of adenosine resulted in aptamer assembly, which did not occur if the split aptamer was attached to silica nanoparticles, ... -
Dissociation and Degradation of Thiol-Modified DNA on Gold Nanoparticles in Aqueous and Organic Solvents
Bhatt, Nishi; Huang, Po-Jung Jimmy; Dave, Neeshma; Liu, Juewen (American Chemical Society, 2011-05-17)Gold nanoparticles functionalized with thiol-modified DNA have been widely used in making various nanostructures, colorimetric biosensors, and drug delivery vehicles. Over the past 15 years, significant progress has been ... -
DNA functionalized soft materials: preparation, biophysical properties and analytical applications.
Dave, Neeshma (University of Waterloo, 2013-01-02)Bio-nanotechnology is the use of biomolecules to control both the structure and property of nanomaterials. No biomolecule has been employed more often than DNA as exemplified in the numerous demonstrations of DNA-directed ... -
DNA-Functionalized Monolithic Hydrogels and Gold Nanoparticles for Colorimetric DNA Detection
Baeissa, Aifan; Dave, Neeshma; Smith, Brendan D.; Liu, Juewen (American Chemical Society, 2010-12-22)Highly sensitive and selective DNA detection plays a central role in many fields of research, and various assay platforms have been developed. Compared to homogeneous DNA detection, surface-immobilized probes allow washing ... -
Electrostatically Directed Visual Fluorescence Response of DNA-Functionalized Monolithic Hydrogels for Highly Sensitive Hg2+ Detection
Dave, Neeshma; Liu, Juewen; Joseph, Kevin A. (American Chemical Society, 2011-03-23)Hydrogels are cross-linked hydrophilic polymer networks with low optical background and high loading capacity for immobilization of biomolecules. Importantly, the property of hydrogel can be precisely controlled by changing ... -
Fast Molecular Beacon Hybridization in Organic Solvents with Improved Target Specificity
Dave, Neeshma; Liu, Juewen (American Chemical Society, 2010-12-02)DNA hybridization is of tremendous importance in biology, bionanotechnology, and biophysics. Molecular beacons are engineered DNA hairpins with a fluorophore and a quencher labeled on each of the two ends. A target DNA can ... -
Instantaneous Attachment of an Ultrahigh Density of Nonthiolated DNA to Gold Nanoparticles and Its Applications
Zhang, Xu; Dave, Neeshma; Servos, Mark R.; Liu, Juewen; Liu, Biwu (American Chemical Society, 2012-12-11)The last 16 years have witnessed the landmark development of polyvalent thiolated DNA-functionalized gold nanoparticles (AuNP's) possessing striking properties within the emerging field of nanobiotechnology. Many novel ... -
Programmable Assembly of DNA-Functionalized Liposomes by DNA
Dave, Neeshma; Liu, Juewen (American Chemical Society, 2011-02-22)Bionanotechnology involves the use of biomolecules to control both the structure and property of nanomaterials. One of the most studied examples is DNA-directed assembly of inorganic nanoparticles such as gold nanoparticles ... -
Protection and Promotion of UV Radiation-Induced Liposome Leakage via DNA-Directed Assembly with Gold Nanoparticles
Dave, Neeshma; Liu, Juewen (Wiley, 2011-07-26)DNA-functionalized gold nanoparticles and liposomes are assembled by a linker DNA. The gold nanoparticles can either protect the liposome from UV radiation induced leakage or can promote the leakage, depending on the DNA ... -
Regenerable DNA-Functionalized Hydrogels for Ultrasensitive, Instrument-Free Mercury(II) Detection and Removal in Water
Dave, Neeshma; Chan, Michelle Y.; Huang, Po-Jung Jimmy; Smith, Brendan D.; Liu, Juewen (American Chemical Society, 2010-09-15)Mercury is a highly toxic environmental pollutant with bioaccumulative properties. Therefore, new materials are required to not only detect but also effectively remove mercury from environmental sources such as water. We ... -
Stimuli-responsive releasing of gold nanoparticles and liposomes from aptamer-functionalized hydrogels
El-Hamed, Firas; Dave, Neeshma; Liu, Juewen (Institute of Physics, 2011-11-21)Controlled release of therapeutic agents is important for improving drug efficacy and reducing toxicity. Recently, hydrogels have been used for controlled release applications. While the majority of the previous work focused ...