Browsing Optometry and Vision Science by Type "Doctoral Thesis"
Now showing items 41-60 of 73
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Motion Processing of Reverse Phi
(University of Waterloo, 2019-11-18)Introduction: When the contrast of the successive images is reversed for a target in an apparent motion stimulus, the perceived direction is reversed, i.e., opposite of phi motion, which is an integration of the sequential ... -
Near addition lenses as a tool to investigate vergence adaptation in myopic children
(University of Waterloo, 2011-08-12)Accommodation and vergence are two interacting ocular motor systems that function to maintain clear and single vision across a wide range of distances. Sustained fixation results in the adaptation of these ocular motor ... -
Neural modulation of the human visual cortex
(University of Waterloo, 2020-09-30)Neuroplasticity is a phenomenon that refers to the brain’s ability to reorganize, strengthen, and form neural connections, a process that becomes increasingly more difficult with age. Gamma amino-butyric acid (GABA), the ... -
Non-invasive brain stimulation of the primary visual cortex of healthy adults and individuals with amblyopia
(University of Waterloo, 2021-05-03)Introduction: Amblyopia is a neurological condition that affects the visual cortex and causes visual deficits, typically in one eye. Recovery from amblyopia requires significant visual cortex neuroplasticity to allow for ... -
A novel Automatic Optic Disc and Cup Image Segmentation System for Diagnosing Glaucoma using RIGA dataset
(University of Waterloo, 2016-04-07)The optic nerve head (ONH) of the retina is a very important landmark of the fundus and is altered in optic nerve pathology especially glaucoma. Numerous imaging systems are available to capture the retinal fundus and from ... -
Ocular Surface Sensory Processing and Signal Detection Theory
(University of Waterloo, 2021-09-28)Purpose: The main aim of the experiments in this thesis is to evaluate the feasibility of using signal detection theory (SDT) to determine the detectability and bias of various ocular surface pneumatic stimuli. Chapter ... -
Overnight Corneal Swelling and Deswelling with Silicone Hydrogel Lenses
(University of Waterloo, 2019-12-13)Purpose: To compare central corneal swelling (CS) after eight hours of sleep in eyes wearing 12 different silicone hydrogel (SiHy) contact lenses (CLs) and to model between-subject variability in CS and deswelling. Methods: ... -
Patient compliance with contemporary contact lenses: Impact on successful contact lens wear
(University of Waterloo, 2013-04-15)Purpose: Contact lens (CL) materials, modalities of wear and replacement, and care systems have changed considerably since the early studies of CL compliance were first conducted. Silicone hydrogel (SiHy) and daily disposable ... -
The Phenotype of Tear Neutrophils and Their Role in Ocular Homeostasis and Inflammation
(University of Waterloo, 2023-07-31)Introduction: Neutrophils (polymorphonuclear neutrophils, PMNs) are part of the innate immune system with potent killing mechanisms against pathogens. Although the anterior segment of the eye has a unique characteristic, ... -
Protein Deposition and Bacterial Adhesion to Conventional and Silicone Hydrogel Contact Lens Materials
(University of Waterloo, 2009-04-27)Introduction Contact lenses suffer from the same problems of deposition that other biomaterials exhibit, being rapidly coated with a variety of proteins, lipids and mucins. The first event observed at the interface between ... -
Protein sorption to contact lenses and intraocular lenses
(University of Waterloo, 2009-12-22)Purpose: To locate protein sorption on the surface and inside the matrix of soft contact lens materials and intraocular lenses (IOL). Methods: The proteins albumin and lysozyme were investigated as they are highly ... -
Psychophysical and Clinical Investigations of Ocular Discomfort
(University of Waterloo, 2012-09-26)Purpose To investigate ocular surface sensations, specifically ocular discomfort using psychophysical and clinical techniques. The measurement of discomfort on the ocular surface has been limited to the use of traditional ... -
Psychophysical Studies Of Motion Perception In Autism Spectrum Disorders
(University of Waterloo, 2019-05-23)Introduction Studies have shown considerable evidence of visual dysfunction in Autism Spectrum Disorders (ASD). Motion perception research in ASD reports a superior performance in processing motion information of fine ... -
Retinal and Optic Nerve Head Vascular Reactivity in Primary Open Angle Glaucoma
(University of Waterloo, 2009-05-14)The global aim of this thesis was to assess retinal vascular reactivity in glaucoma patients using a standardised hypercapnic stimulus. There is a suggestion of disturbance in the regulation of retinal and optic nerve head ... -
Retinal Blood Flow and Vascular Reactivity in Diabetic Retinopathy
(University of Waterloo, 2006-12-18)Introduction Retinal vascular reactivity is impaired in patients with diabetes and is thought to be involved in the onset and progression of diabetic retinopathy (DR). Previous studies that have utilized hyperoxia to ... -
Retinal Blood Oxygen Saturation and Angiogenic and Inflammatory Biomarkers in Type 2 Diabetes
(University of Waterloo, 2015-01-16)Introduction: Diabetic retinopathy (DR) is a major source of visual loss in the world, including North America. A number of hyperglycemia-related pathways have been associated with DR onset and progression. Disturbances ... -
Retinal Haemodynamics in Primary Open Angle Glaucoma Patients with Differing Nocturnal Blood Pressure Profiles
(University of Waterloo, 2014-08-14)The impairment of ocular haemodynamics has been reported in primary open angle glaucoma (POAG) patients using various blood flow measurement techniques. Studies have shown hypotension may accelerate progression in POAG and ... -
Retinal perfusion changes in radiation retinopathy-post brachytherapy for choroidal melanoma
(University of Waterloo, 2017-04-21)Introduction: Radiation retinopathy (RR) is a chronic progressive vasculopathy developing secondary to the impact of ionizing radiation to the retina. RR develops post radiation therapy using radioactive plaque to treat ... -
The Role of MMPs, Smad3 and Heat Shock Proteins in TGF-β-Induced Anterior Subcapsular Cataract Development
(University of Waterloo, 2007-06-18)Transforming growth factor beta (TGF-β) has been implicated in anterior subcapsular cataract (ASC) development. In the first section of this thesis, an in-vitro rat lens model was used to determine the role of matrix ... -
Sensitivity Across the Ocular Surface—Fundamental Findings and Clinical Applications
(University of Waterloo, 2010-04-29)Current understanding of sensitivity and sensation experienced across the ocular surface remains limited. This project explored the regional variation of corneal sensitivity and transducer function, interaction of sensory ...