Now showing items 1-8 of 8

    • Distinction of Individual Lanthanide Ions with a DNAzyme Beacon Array 

      Huang, Po-Jung Jimmy; Vazin, Mahsa; Lin, Jennifer J.; Pautler, Rachel; Liu, Juewen (American Chemical Society, 2016-06-24)
      Developing chemical probes to distinguish each lanthanide ion is a long-standing challenge. Aside from its analytical applications, solving this problem will also enhance our knowledge in metal ligand design. Using in vitro ...
    • A DNAzyme requiring two different metal ions at two distinct sites 

      Zhou, Wenhu; Zhang, Yupei; Huang, Po-Jung Jimmy; Ding, Jinsong; Liu, Juewen (Oxford University Press, 2015-12-10)
      Most previously reported RNA-cleaving DNAzymes require only a single divalent metal ion for catalysis. We recently reported a general trivalent lanthanide-dependent DNAzyme named Ce13d. This work shows that Ce13d requires ...
    • A highly specific sodium aptamer probed by 2-aminopurine for robust Na+ sensing 

      Zhou, Wenhu; Ding, Jinsong; Liu, Juewen (Oxford University Press, 2016-09-20)
      Sodium is one of the most abundant metals in the environment and in biology, playing critical ecological and physiological roles. Na+ is also the most common buffer salt for nucleic acids research, while its specific ...
    • Molecularly Imprinted Polymers with DNA Aptamer Fragments as Macromonomers 

      Zhang, Zijie; Liu, Juewen (American Chemical Society, 2016-03-16)
      Molecularly imprinted polymers (MIPs) are produced in the presence of a template molecule. After removing the template, the cavity can selectively rebind the template. MIPs are attractive functional materials with a low ...
    • A New Na+-Dependent RNA-Cleaving DNAzyme with over 1000-fold Rate Acceleration by Ethanol 

      Zhou, Wenhu; Saran, Runjhun; Chen, Qingyun; Ding, Jinsong; Liu, Juewen (Wiley, 2016-01-15)
      Enzymes working in organic solvents are important for analytical chemistry, catalysis, and mechanistic studies. Although a few protein enzymes are highly active in organic solvents, little is known regarding nucleic ...
    • A Selective Na+ Aptamer Dissected by Sensitized Tb3+ Luminescence 

      Zhou, Wenhu; Ding, Jinsong; Liu, Juewen (Wiley, 2016-08-17)
      A previous study of two RNA-cleaving DNAzymes, NaA43 and Ce13d, revealed the possibility of a common Na+ aptamer motif. Because Na+ binding to DNA is a fundamental biochemical problem, the interaction between Ce13d and Na+ ...
    • A Silver DNAzyme 

      Saran, Runjhun; Liu, Juewen (American Chemical Society, 2016-04-05)
      Silver is a very common heavy metal, and its detection is of significant analytical importance. DNAzymes are DNA-based catalysts; they typically recruit divalent and trivalent metal ions for catalysis. Herein, we report a ...
    • An Ultrasensitive Light-up Cu2+ Biosensor Using a New DNAzyme Cleaving a Phosphorothioate-Modified Substrate 

      Huang, Po-Jung Jimmy; Liu, Juewen (American Chemical Society, 2017-01-15)
      Cu2+ is a very important metal ion in biology, environmental science, and industry. Developing biosensors for Cu2+ is a key topic in analytical chemistry. DNAzyme-based sensors are highly attractive:, for their excellent ...


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