Browsing Theses by Subject "evolution"
Now showing items 1-11 of 11
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Alternative splicing of Lymnaea Cav3 and NALCN ion channel genes serves to alter biophysical properties, membrane expression, and ion selectivity
(University of Waterloo, 2012-08-30)Evidence is presented that Lymnaea contains homologues for mammalian Cav3 and NALCN 4-domain ion channels, which retain key amino acid sequence motifs that differentiate these channels from other 4-domain types. Molecular ... -
Catalytic Potential and Ligand Binding Properties of the Malachite Green RNA Aptamer
(University of Waterloo, 2008-09-18)The malachite green aptamer was originally engineered for binding specificity to malachite green (MG). The environment inside the aptamer’s electronegative binding pocket was previously harnessed to catalyze an ester ... -
Computational Design of Protein Structure and Prediction of Ligand Binding
(University of Waterloo, 2016-08-23)Proteins perform a tremendous array of finely-tuned functions which are not only critical in living organisms, but can be used for industrial and medical purposes. The ability to rationally design these molecular machines ... -
A Data Mining Approach for Detecting Evolutionary Divergence in Transcriptomic Data
(University of Waterloo, 2019-11-19)It has become common to produce genome sequences for organisms of scientific or popular interest. Although these genome projects provide insight into the gene and protein complements of a species including their evolutionary ... -
Data, Debt & Daemons: Systemic Asymmetries on Spaceship Earth
(University of Waterloo, 2019-10-17)Day by day, the rate at which we create new data increases exponentially. Our capacity to learn cannot keep up. We are tiny members of a vast universal network, incapable of discerning cause and effect. Instead, we develop ... -
Forging links between innovation and sustainability:An empirical examination of the effects on a firm’s financial performance
(University of Waterloo, 2016-04-29)Greenhouse gas (GHG) emissions from the North American energy and energy-intensive materials production sectors account for more than 50 percent of total GHG emissions. Based on the argument that CO2 emissions need to be ... -
From Peptides to Proteins: Exploring Modular Evolution Through the Beta-Trefoil Fold
(University of Waterloo, 2010-01-25)Understanding the origin of protein folds, and the mechanism by which evolution has generated them, is a critically important step on a path towards rational protein design. Modifying existing proteins and designing our ... -
Mutation rates of Escherichia coli with different balanced growth rates: a new fluctuation test protocol and phenotypic lag adjustments
(University of Waterloo, 2020-10-23)Bacteria are the oldest, most abundant life form on the planet, and every other organism’s livelihood is dependent on them. The bacteria Escherichia coli (E. coli) is commonly used in microbiology as a model organism to ... -
Obus: Intent and Inhabitation
(University of Waterloo, 2019-09-23)First proposed by Le Corbusier for the city of Algiers in 1932 but never built, the Plan Obus is Le Corbusier’s ultimate city planning project. The forerunner of the megastructures projects of the 1960s, it sits squarely ... -
Paleoevolution of Pore Fluids in Glaciated Geologic Settings
(University of Waterloo, 2009-06-17)Nuclear power generation is being regarded as a solution to ever increasing demand for electricity, and concerns over global warming and climate change due to the use of fossil fuels. Although nuclear power generation is ... -
The Psychology of Nature: Our Dwellings, Well-being, and Evolutionary Preferences
(University of Waterloo, 2023-08-28)Nature has always played a significant role in the human experience. Throughout prehistory, our early ancestors experienced life through a purely natural world. As an evolutionary mechanism aiding their survival and ...