Browsing Theses by Title
Now showing items 10864-10883 of 15573
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Peptide Mediated siRNA Delivery: Physicochemical and in vitro Characterizations
(University of Waterloo, 2008-01-22)Short interfering RNAs (siRNAs) trigger RNA interference (RNAi) both in vitro and in vivo, where the expression of the encoded protein is silenced. Its potential use as a therapeutic agent is limited by its rapid enzymatic ... -
Peptide Sequencing with Deep Learning
(University of Waterloo, 2020-09-30)In shotgun proteomics, de novo peptide sequencing from tandem mass spectrometry data is the key technology for finding new peptide or protein sequences. It has successful applications in assembling monoclonal antibody ... -
Peptide-Driven Tri-Modal Gene Delivery Systems (PDTMG): Novel Versatile Peptide-Based Lipopolyplexes Incorporating Peptide-Functionalized Gemini Surfactants for Targeted Gene Therapy- Implementation of RGD Motifs as a Means for Endosomal Escape
(University of Waterloo, 2018-09-04)The development of non-viral gene delivery vectors is highly challenging and aims to provide a safe while cost-effective manufacturing alternative to viral vectors. Eleven novel gemini surfactants (G4-G14) were designed ... -
Peptide-Mediated Anticancer Drug Delivery
(University of Waterloo, 2009-08-21)An ideal drug delivery system should contain an appropriate therapeutic agent and biocompatible carrier. In this study, we investigated the ability of the all-complementary self-assembling peptide AC8 in stabilizing the ... -
Perceived Barriers to Exercise among Older Adults with MCI and Early Dementia
(University of Waterloo, 2017-09-08)Increasing evidence suggests that exercise can benefit physical and cognitive function among older adults with mild cognitive impairment (MCI) and early dementia (MCI/dementia). Unfortunately, many older adults with ... -
Perceived Emotional Synchrony in Virtual Watch Parties
(University of Waterloo, 2022-02-28)The appeal of many leisure activities emerges from “shared experience,” wherein participants feel an emotional synchrony with fellow participants. Essentially, participants’ emotions are enhanced by their awareness of and ... -
Perceived Risk of Tobacco Products among Adult Tobacco Users in Bangladesh and India
(University of Waterloo, 2014-10-27)There is considerable evidence demonstrating that smokers underestimate or minimize their own perceived risk of harm from smoking, and that smokers’ perceptions of risk play a key role in their behaviour, notably quitting. ... -
Perceived Stress, Physiological Stress, and Mental Health in Parents and Children
(University of Waterloo, 2021-09-23)Background: Elevated stress levels have been linked to a variety of health concerns, including mental disorders, making stress an important topic of research and clinical assessment. The human stress response involves the ... -
Perceived Susceptibility to Developing Cancer and Cancer Screening Behaviour: A Longitudinal Analysis of Alberta’s Tomorrow Project
(University of Waterloo, 2017-10-25)Background: Screening for cancer is a secondary prevention strategy that relies on early detection of disease. Screening is given to asymptomatic individuals who are at risk of developing cancer to identify and halt the ... -
Perceived Timing of Active Head Movements at Different Speeds
(University of Waterloo, 2018-06-11)The central nervous system must determine which sensory events occur at the same time. Actively moving the head corresponds with large changes in the relationship between the observer and the environment, sensorimotor ... -
Perceived Timing of Auditory and Inertial Cues During a Postural Perturbation In Younger and Older Adults
(University of Waterloo, 2015-10-05)How the perceived timing of sensory events changes during a fall is relatively unknown. Common anecdotal reports suggest that people often report distortions in their perception of time with very little recollection of ... -
The perceived unmet need for home care and impact on frailty related health outcomes among community-dwelling middle-aged and older adults in Canada
(University of Waterloo, 2020-04-22)With the aging population, there is an increased need for the development of interventions and prevention programs to mitigate the impact of frailty on the health and well-being of older Canadians. The association between ... -
Perceiving direct and averted gaze during emotion discrimination, affective empathy and affective theory of mind judgements: electrophysiological and behavioural effects
(University of Waterloo, 2020-08-05)Our observations about the eye-gaze of others inform how we interact with them. Perception of direct gaze has been shown to impact emotional and self-referential processing differently than perception of averted gaze, which ... -
Perception and Evaluation of Land Management Strategies in Borneo for Novelty and Sustainability
(University of Waterloo, 2015-07-10)This thesis examines subsistence production and state-level government forestry land management strategies as practiced in Sarawak, Malaysia. Subsistence farmers in Rumah Siba Perdu and Sarawak Forestry officials practice ... -
Perception and Prediction in Multi-Agent Urban Traffic Scenarios for Autonomous Driving
(University of Waterloo, 2023-09-21)In multi-agent urban scenarios, autonomous vehicles navigate an intricate network of interactions with a variety of agents, necessitating advanced perception modeling and trajectory prediction. Research to improve perception ... -
Perception of Compliance in Laparoscopic Surgery
(University of Waterloo, 2009-05-21)Laparoscopic surgery provides major benefits to patients in terms of decreased pain and post-operative hospital stays, but also increases their risks of intra-operative injuries because of the reduction in feedback in the ... -
Perception of Importance and Performance of Certified Costa Rican Ecolodges
(University of Waterloo, 2013-01-02)With the growth ecotourism and of nature-based tourism, ecolodges are becoming more popular as an accommodation choice by tourists. There is currently no universal certification program ensuring service quality or environmental ... -
The perception of mental health amongst medical students and instructors in Libya: A qualitative study
(University of Waterloo, 2023-09-14)Background: Medical students that reside in high-conflict areas are at risk for developing mental health challenges. Moreover, the stigmatization of mental disorders in Libya have reduced the collection and reporting of ... -
Perception of Naturalness in a Hybrid Landscape: A Case Study of Citizens Engaged in Oak Ridges Moraine Conservation
(University of Waterloo, 2011-01-24)Conservation in Canada is increasingly driven by land use planning processes. Approaches to governing nature conservation have shifted dramatically from protecting isolated pristine areas to greater attention to the remaining ... -
Perception of Probabilities which are Subject to Change
(University of Waterloo, 2022-08-29)To navigate stochastic and changing environments, people need to keep track of ongoing probabilities as those probabilities are subject to change. Two distinct theories of mental-model updating are compared. In trial-by-trial ...