Browsing Engineering (Faculty of) by Subject "siRNA"
Now showing items 1-5 of 5
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Design, Characterization and Application of Amphipathic Peptides for siRNA Delivery
(University of Waterloo, 2013-01-25)Short interfering RNAs (siRNAs) are 21-23 nucleotide-long double-stranded RNA molecules that can trigger the RNA interference (RNAi). RNAi is a post-transcriptional gene silencing process whereby siRNAs induce the ... -
Endosomolytic arginine-rich peptides for therapeutic siRNA delivery
(University of Waterloo, 2014-07-23)At the forefront of revolutionizing medicine, gene therapy provides an effective way to treat a range of diseases by regulating defective genes at the root of the disease. Short interfering RNA (siRNA) holds great promise ... -
Matrix Metalloproteinase-2 Cleavable Peptide-Based siRNA Delivery System for Cancer Treatment
(University of Waterloo, 2019-09-23)Among all kinds of gene therapy, siRNA, a class of 20 to 25 nucleotide-long double-stranded RNA molecules, is one of the promising therapeutic solutions to regulate post-transcriptional process for cancer treatment. However, ... -
Peptide Mediated siRNA Delivery: Physicochemical and in vitro Characterizations
(University of Waterloo, 2008-01-22)Short interfering RNAs (siRNAs) trigger RNA interference (RNAi) both in vitro and in vivo, where the expression of the encoded protein is silenced. Its potential use as a therapeutic agent is limited by its rapid enzymatic ... -
Stearylated Peptides for Therapeutic siRNA Delivery and Their Cellular Uptake Mechanisms
(University of Waterloo, 2015-10-15)Small interfering RNA (siRNA) shows great potential as a powerful tool in gene therapy, due to its ability to regulate gene expression in a highly selective manner. siRNA is a double-stranded RNA consisting of 21–23 ...