Browsing Theses by Subject "peptide"
Now showing items 1-8 of 8
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Design, Characterization and Application of Amphipathic Peptides for siRNA Delivery
(University of Waterloo, 2013-01-25)Short interfering RNAs (siRNAs) are 21-23 nucleotide-long double-stranded RNA molecules that can trigger the RNA interference (RNAi). RNAi is a post-transcriptional gene silencing process whereby siRNAs induce the ... -
Endosomolytic arginine-rich peptides for therapeutic siRNA delivery
(University of Waterloo, 2014-07-23)At the forefront of revolutionizing medicine, gene therapy provides an effective way to treat a range of diseases by regulating defective genes at the root of the disease. Short interfering RNA (siRNA) holds great promise ... -
Interactions of Cationic Peptides and Ions with Negatively Charged Lipid Bilayers
(University of Waterloo, 2006)In this thesis we study the interactions of ions and cationic peptides with a negatively charged lipid bilayer in an ionic solution where the electrostatic interactions are screened. <br /><br /> We first examine the ... -
Ionic-complementary Peptide Modified Electrode for Biosensing Application
(University of Waterloo, 2009-09-17)Self-assembling peptides have emerged as new nanobiomaterials and received considerable attention in the areas of nanoscience and biomedical engineering. One important type is the ionic-complementary peptide, which contains ... -
Multifunctional Nano MOF Particle for Anticancer Drug Delivery
(University of Waterloo, 2022-01-05)PCN-224 MOF nano particles were modified with a peptide named NPKMTX to deliver dox to cancer cells. -
Peptide Mediated siRNA Delivery: Physicochemical and in vitro Characterizations
(University of Waterloo, 2008-01-22)Short interfering RNAs (siRNAs) trigger RNA interference (RNAi) both in vitro and in vivo, where the expression of the encoded protein is silenced. Its potential use as a therapeutic agent is limited by its rapid enzymatic ... -
Seeding Induced Assembly of Ionic-Complementary Peptide EAK16-II
(University of Waterloo, 2004)Seeding is an important variable in controlling or directing the assembly of peptides. The presence of impurities, responsible for creating a 'dip' in the surface tension versus peptide concentration profile, is used to ... -
Synthesis and Study of the Cyclic Lipopeptide Antibiotics Paenibacterin and Daptomycin
(University of Waterloo, 2021-09-23)Cyclic lipopeptides present a rich source of antimicrobial compounds with diverse modes of action. Paenibacterin is a cyclic lipopeptide antibiotic produced by Paenibacillus thaminolyticus that exhibits activity against a ...