Browsing Theses by Subject "metagenomics"
Now showing items 1-12 of 12
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AlignDx: Enabling Automated, Cloud-Based Workflows for Streamlined Bioinformatic-Focused Pathogen Surveillance
(University of Waterloo, 2023-07-13)The rising trends in infectious disease burden, alongside the recent COVID-19 pandemic, underline the need for effective public health disease mitigation strategies like pathogen surveillance. Improvements to surveillance ... -
Bacterial diversity and denitrifier communities in arable soils
(University of Waterloo, 2014-05-21)Agricultural management is essential for achieving optimum crop production and maintaining soil quality. Soil microorganisms are responsible for nutrient cycling and are an important consideration for effective soil ... -
Diversity of Viral Communities in a Northern Temperate Lake through Metagenomics
(University of Waterloo, 2023-04-05)Viruses in oceanic environments play pivotal roles in regulating nutrient transfer and increasing rates of carbon transport. They have also been implicated in the regulation of micro-organism community dynamics through ... -
Investigating Cyanobacterial Communities Across Canada and Characterizing the Seasonality of Cyanobacterial Toxin and Nitrogen Metabolism Genes in the Turkey Lakes Watershed Using Metagenomics
(University of Waterloo, 2023-08-08)The long evolutionary history of gram-negative cyanobacteria has enabled them to tolerate extreme conditions, succeed in numerous habitats, and exploit special nutrients, all while resisting harmful anthropogenic and climate ... -
Isolation and characterization of bacterial phosphorous metabolism genes from complex microbial communities
(University of Waterloo, 2009-10-05)Phosphorous (P) is an essential nutrient, playing a central role in the life of a bacterial cell. It is involved in cellular metabolic pathways, cell signaling and is a component of many of the cell’s macromolecules. Since ... -
A Metagenomic Examination of Virus Diversity, Host Interactions, and Genetic Potential Across Municipal Waste Sites
(University of Waterloo, 2023-09-18)Viruses are the most abundant microbial guild on the planet, impacting microbial community structure and ecosystem services. Despite this, they have been underrepresented in reference databases compared to Bacteria and ... -
Microbial diversity and cellulosic capacity in municipal waste sites
(University of Waterloo, 2019-01-25)Cellulose is the most abundant organic compound found on earth. Cellulose’s recalcitrance to hydrolysis is a major limitation to improving the efficiency of industrial applications. The biofuel, pulp and paper, agriculture, ... -
Microbial Ecology of Phototrophs in Iron-rich Boreal Shield Lakes
(University of Waterloo, 2020-09-24)The early Earth oceans of the Archaean Eon (approx. 3.8-2.5 billion years ago) are thought to have been predominantly anoxic with ferruginous waters containing high levels of dissolved ferrous iron and low levels of sulfate. ... -
MT-MAG: Accurate and interpretable machine learning for complete or partial taxonomic assignments of metagenome-assembled genomes
(University of Waterloo, 2022-05-19)We propose MT-MAG, a novel machine learning-based software tool for the complete or partial hierarchically-structured taxonomic classification of metagenome-assembled genomes (MAGs). MT-MAG is capable of classifying large ... -
The Proximon: Representation, Evaluation, and Applications of Metagenomic Functional Interactions
(University of Waterloo, 2017-09-19)The effective use of metagenomic functional interactions represents a key prospect for a variety of applications in the field of functional metagenomics. By definition, metagenomic operons represent such interactions but ... -
Targeted enrichment of cellulase genes using stable-isotope probing and metagenomics
(University of Waterloo, 2012-01-23)Cellulose is the most abundant organic compound on the planet, and is found in nearly every ecosystem. Cellulose is also the most abundant waste product produced by human activity. These enormous stores of natural cellulose ... -
Targeting novel soil glycosyl hydrolases by combining stable isotope probing and metagenomics
(University of Waterloo, 2014-02-25)Soil represents the largest global reservoir of microbial diversity for the discovery of novel genes and enzymes. Both stable-isotope probing (SIP) and metagenomics have been used to access uncultured microbial diversity, ...