Browsing Chemistry by Subject "Calmodulin"
Now showing items 1-7 of 7
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Biophysical Investigations of the Interactions between Calmodulin and Nitric Oxide Synthase Enzymes
(University of Waterloo, 2017-12-15)Nitric Oxide (•NO) is an essential biomolecule that has physiological functions in neurotransmission, vasodilation and immune response. •NO is produced by a family of enzymes known as nitric oxide synthases (NOS). NOS ... -
Calmodulin Binding and Activation of Mammalian Nitric Oxide Synthases
(University of Waterloo, 2008-05-12)Calmodulin (CaM) is a ubiquitous cytosolic Ca2+-binding protein involved in the binding and regulation of more than three-hundred intracellular target proteins. CaM consists of two globular domains joined by a central ... -
Chemical shift assignments of calmodulin constructs with EF hand mutations
(Springer, 2016-04-01)Calmodulin (CaM) is a ubiquitous cytosolic Ca2+-binding protein able to bind and regulate hundreds of different proteins. It consists of two globular domains joined by a flexible central linker region. Each one of these ... -
Chemical shift perturbations induced by residue specific mutations of CaM interacting with NOS peptides
(Springer, 2015-10-01)The regulation of nitric oxide synthase (NOS) by calmodulin (CaM) plays a major role in a number of key physiological and pathological processes. A detailed molecular level picture of how this regulation is achieved is ... -
Investigation of the effect mutations of CaM have upon in vitro and ex vivo function
(University of Waterloo, 2010-01-22)Calmodulin (CaM) is a calcium-binding protein that has promiscuous regulatory interactions with over three hundred intracellular protein targets. The focus of this study was to characterize the functional role of phosphorylated ... -
NMR Studies of Protein and Peptide Structure and Dynamics
(University of Waterloo, 2016-04-18)Calmodulin (CaM) is a small, acidic cytosolic calcium binding protein that responds to increases in intracellular Ca2+ concentrations. It is proposed to be involved in binding to and regulating over 300 functionally and ... -
NMR Study of Calmodulin’s Interaction with Inducible Nitric Oxide Synthase
(University of Waterloo, 2010-01-22)The increase of calcium in the cell can induce cellular functions such as fertilization, cell division and cell communication. Calcium (Ca2+) carries out these processes through proteins called calcium sensors. An important ...