Browsing Mechanical and Mechatronics Engineering by Author "Chen, Xiaoming"
Now showing items 1-7 of 7
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Droplet Microfluidic System with On-Demand Trapping and Releasing of Droplet for Drug Screening Applications
Courtney, Matthew; Chen, Xiaoming; Chan, Sarah; Mohamed, Tarek; Rao, Praveen P.N.; Ren, Carolyn L. (American Chemical Society (ACS), 2017-01-03)96-Well plate has been the traditional method used for screening drug compounds libraries for potential bioactivity. Although this method has been proven successful in testing doseÐresponse analysis, the microliter consumption ... -
Droplet-based Microfluidic Chip Design for High Throughput Screening Applications
Chen, Xiaoming (University of Waterloo, 2015-12-11)Droplet-based microfluidics has been considered as a prospective tool for high throughput screening analysis, which is highly demanded in a wide range of areas including but not limited to life science research, drug ... -
A droplet-based microfluidic platform for rapid immobilization of quantum dots on individual magnetic microbeads
Nguyen, Thu H.; Chen, Xiaoming; Sedighi, Abootaleb; Krull, Ulrich J.; Ren, Carolyn L. (Springer Nature, 2018-06-01)Quantum dots (QDs) provide opportunities for the development of bioassays, biosensors, and drug delivery strategies. Decoration of the surface of QDs offers unique functions such as resistance to non-specific adsorption, ... -
Experimental study on droplet generation in flow focusing devices considering a stratified flow with viscosity contrast
Chen, Xiaoming; Ren, Carolyn L. (Elsevier BV, 2017-05-18)High throughput analysis is highly demanded in a variety of chemical reactions. Droplet microfluidics offers unique advantages over traditional multi-well plate systems for high throughput analysis such as providing a ... -
A microfluidic chip integrated with droplet generation, pairing, trapping, merging, mixing and releasing
Chen, Xiaoming; Ren, Carolyn L. (Royal Society of Chemistry (RSC), 2017-03-16)Developing a microfluidic chip with multiple functions is highly demanded for practical applications, such as chemical analysis, diagnostics, particles synthesis and drug screening. This work demonstrates a microfluidic ... -
A simple droplet merger design for controlled reaction volumes
Chen, Xiaoming; Brukson, Alexander; Ren, Carolyn L. (Springer Nature, 2017-04-01)Droplet microfluidics has been proven to be a viable platform for a variety of reactions by using uniform droplets well encapsulated by an immiscible carrier medium as reaction vesicles. Merging as one of the most basic ... -
Simulation before fabrication: a case study on the utilization of simulators for the design of droplet microfluidic networks
Grimmer, Andreas; Chen, Xiaoming; Hamidovic, Medina; Haselmayr, Werner; Ren, Carolyn L.; Wille, Robert (Royal Society of Chemistry (RSC), 2018-10-10)The functional performance of passively operated droplet microfluidics is sensitive with respect to the dimensions of the channel network, the fabrication precision as well as the applied pressure because the entire network ...