Browsing Theses by Subject "oxidative stress"
Now showing items 1-6 of 6
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An Assessment of Pyridoxine as a Biological Response Modifier During Colon Carcinogenesis
(University of Waterloo, 2007-10-05)The main objective of this proposal was to investigate the effect of vitamin B6 on colon carcinogenesis in vivo. Two in vivo studies were conducted to determine the role of vitamin B6 as a biological modifier of colon ... -
Contact Lenses and Tear Film Lipids.
(University of Waterloo, 2017-12-20)Introduction Lipids are essential tear components that aid the stability of the tear film (TF) to protect it from excess evaporation. The composition, conformation, and function of TF lipids are jeopardized by external ... -
Improving Productivity in Bioreactors through Control of Cell Heterogeneity
(University of Waterloo, 2022-12-22)Whooping cough, also referred to as pertussis, is a highly contagious bacterial respiratory tract disease. At Sanofi Pasteur, the fermentation step in the manufacturing of the vaccine for pertussis involves a sequence of ... -
An in vitro model of oxidative damage in bovine cortical bone to induce bone fragility
(University of Waterloo, 2021-08-19)Increased bone fragility can stem from age-related and chronic bone affecting diseases (such as osteoporosis, diabetes and kidney disease), chemotherapeutic and radiation-based cancer treatments, and/or trauma and results ... -
Mechanisms of over-active endothelium-derived contracting factor signaling causing common carotid artery endothelial vasomotor dysfunction in hypertension and aging
(University of Waterloo, 2011-03-09)Background and Purpose: The endothelium is a single-cell layer positioned at the blood-vascular wall interface, where in response to blood-borne signals and hemodynamic forces, endothelial cells act as central regulators ... -
The role of phospholamban (PLN) in potential protection of sarc(endo)plasmic reticulum Ca2+-ATPase (SERCA) against oxidative stress
(University of Waterloo, 2015-01-23)Sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) sequesters Ca2+ from the cytosol to: i) aid in muscular relaxation and ii) refill SR Ca2+ stores for release upon subsequent stimulus for contraction. SERCA function is ...