Browsing Theses by Subject "autophagy"
Now showing items 1-5 of 5
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Apoptotic signalling and structural alterations in autophagy-deficient murine skeletal muscle
(University of Waterloo, 2014-10-15)Autophagy is a catabolic process by which the cell targets and degrades cytoplasmic materials, such as proteins and organelles. Autophagy is required for the control of muscle mass under catabolic conditions, but is also ... -
Autophagic cell death during Drosophila embryogenesis
(University of Waterloo, 2012-01-23)The amnioserosa (AS) is an extraembryonic tissue that undergoes programmed cell death (PCD) during the normal course of Drosophila embryogenesis. AS degeneration involves morphological evidence of autophagy as well as ... -
Examining the role of autophagy in modulating apoptotic signaling and skeletal muscle recovery after cardiotoxin injury in tamoxifen-inducible, skeletal muscle-specific Atg7 knockdown mice
(University of Waterloo, 2015-10-06)Skeletal muscle is a unique tissue composed of multinucleated, post-mitotic fibers. Despite its post-mitotic nature, skeletal muscle has an astounding ability to regenerate after injury largely thanks to muscle-specific ... -
Investigating the Importance of RAB7 in C2C12 Myoblast Differentiation
(University of Waterloo, 2021-06-01)Prior research has shown that autophagy and mitophagy are intimately linked to skeletal muscle differentiation and myogenesis. Recent studies show that the RAB7 cycle is crucial in multiple stages of autophagy and mitophagy; ... -
Optimizing protein S-acylation detection in autophagy
(University of Waterloo, 2021-06-04)S-acylation, sometimes referred to as S-palmitoylation or simply palmitoylation, is a posttranslational protein modification involving the covalent addition of a fatty acid to cysteine residues. Since the first characterization ...