Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram ResponsesShort-Term Elevated IOP and Scotopic ERG Responses

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dc.contributor.authorChoh, Vivian Cheng-Pei
dc.contributor.authorGurdita, Akshay
dc.contributor.authorTan, Bingyao
dc.contributor.authorPrasad, Ratna C.
dc.contributor.authorBizheva, Kostadinka
dc.contributor.authorJoos, Karen M.
dc.date.accessioned2017-02-22T14:57:50Z
dc.date.available2017-02-22T14:57:50Z
dc.date.issued2016-04-01
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed. Original publication: Choh, V., Gurdita, A., Tan, B., Prasad, R. C., Bizheva, K., & Joos, K. M. (2016). Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram ResponsesShort-Term Elevated IOP and Scotopic ERG Responses. Investigative Ophthalmology & Visual Science, 57(4), 2140–2151. https://doi.org/10.1167/iovs.15-18770en
dc.description.abstractModerately elevated intraocular pressure (IOP) is a risk factor for open-angle glaucoma. Some patients suffer glaucoma despite clinically measured normal IOPs. Fluctuations in IOP may have a significant role since IOPs are higher during sleep and inversion activities. Controlled transient elevations of IOPs in rats over time lead to optic nerve structural changes that are similar to the early changes observed in constant chronic models of glaucoma. Because early intervention decreases glaucoma progression, this study was done to determine if early physiological changes to the retina could be detected with noninvasive electrophysiological and optical imaging tests during moderately elevated IOP.en
dc.description.sponsorshipSupported by the Natural Sciences and Engineering Research Council (NSERC) of Canada Discovery Grants (VC, KB), the Ontario Research Fund (KB), the Canadian Foundation for Innovation (VC), the University of Waterloo Propel Centre Grant (VC, KB, KMJ), University of Waterloo Research Incentive Fund (KB, VC, KMJ), Joseph Ellis Family and William Black Research Funds (KMJ), VUMC Cell Imaging Shared Resource supported by Vanderbilt Vision Research Center-NIH 5P30EY008126-27 (KMJ), and Unrestricted Vanderbilt Eye Institute Departmental Grant from Research to Prevent Blindness, Inc., N.Y. (KMJ).en
dc.identifier.urihttps://doi.org/10.1167/iovs.15-18770
dc.identifier.urihttp://hdl.handle.net/10012/11328
dc.language.isoenen
dc.publisherAssociation of Research in Vision and Ophthalmologyen
dc.relation.ispartofseriesInvestigative Ophthalmology & Visual Science;57(4)en
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectEye Anatomy and Disordersen
dc.subjectGlaucomaen
dc.subjectRetinaen
dc.subjectVisual Neuroscienceen
dc.subjectRetinal Imagingen
dc.titleShort-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram ResponsesShort-Term Elevated IOP and Scotopic ERG Responsesen
dc.typeArticleen
dcterms.bibliographicCitationChoh, V., Gurdita, A., Tan, B., Prasad, R. C., Bizheva, K., & Joos, K. M. (2016). Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram ResponsesShort-Term Elevated IOP and Scotopic ERG Responses. Investigative Ophthalmology & Visual Science, 57(4), 2140–2151. https://doi.org/10.1167/iovs.15-18770en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2School of Optometry and Vision Scienceen
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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