Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram ResponsesShort-Term Elevated IOP and Scotopic ERG Responses
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Date
2016-04-01
Authors
Choh, Vivian Cheng-Pei
Gurdita, Akshay
Tan, Bingyao
Prasad, Ratna C.
Bizheva, Kostadinka
Joos, Karen M.
Advisor
Journal Title
Journal ISSN
Volume Title
Publisher
Association of Research in Vision and Ophthalmology
Abstract
Moderately elevated intraocular pressure (IOP) is a risk factor for open-angle glaucoma. Some patients suffer glaucoma despite clinically measured normal IOPs. Fluctuations in IOP may have a significant role since IOPs are higher during sleep and inversion activities. Controlled transient elevations of IOPs in rats over time lead to optic nerve structural changes that are similar to the early changes observed in constant chronic models of glaucoma. Because early intervention decreases glaucoma progression, this study was done to determine if early physiological changes to the retina could be detected with noninvasive electrophysiological and optical imaging tests during moderately elevated IOP.
Description
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.
Original publication:
Choh, V., Gurdita, A., Tan, B., Prasad, R. C., Bizheva, K., & Joos, K. M. (2016). Short-Term Moderately Elevated Intraocular Pressure Is Associated With Elevated Scotopic Electroretinogram ResponsesShort-Term Elevated IOP and Scotopic ERG Responses. Investigative Ophthalmology & Visual Science, 57(4), 2140–2151. https://doi.org/10.1167/iovs.15-18770
Keywords
Eye Anatomy and Disorders, Glaucoma, Retina, Visual Neuroscience, Retinal Imaging