Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry

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dc.contributor.authorHuang, Po-Jung Jimmy
dc.contributor.authorWang, Feng
dc.contributor.authorLiu, Juewen
dc.date.accessioned2017-04-28T16:12:03Z
dc.date.available2017-04-28T16:12:03Z
dc.date.issued2015-03-15
dc.descriptionThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, © DATE American Chemical Society after peer review and technical editing by publisher. To access the final edited and published work see Huang, P.-J. J., Wang, F., & Liu, J. (2016). Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry. Langmuir, 32(10), 2458–2463. https://doi.org/10.1021/acs.langmuir.6b00006en
dc.description.abstractThe interaction between graphene oxide (GO) and lipid bilayers is important for fundamental surface science and many applications. In this work, isothermal titration calorimetry (ITC), cryo-TEM, and fluorescence spectroscopy were used to study the adsorption of three types of liposomes. Heat release was observed when GO was mixed with zwitterionic DOPC liposomes, while heat absorption occurred with cationic DOTAP liposomes. For comparison,. anionic DOPG liposomes released heat when mixed with DOTAP. DOPC was adsorbed as intact liposomes, but DOTAP ruptured and induced stacking and folding of GO sheets. This study suggests the release of more water molecules from the GO surface when mixed with DOTAP liposomes. This can be rationalized by the full rupture of the DOTAP liposomes interacting with the whole GO surface, including hydrophobic regions, while DOPC liposomes only interact with a small area on GO near the edge, which is likely to be more hydrophilic. This interesting biointerfacial observation has enhanced our fundamental understanding of lipid/GO interactions.en
dc.description.sponsorshipNatural Sciences and Engineering Research Council of Canada (NSERC)en
dc.identifier.urihttp://dx.doi.org/10.1021/acs.langmuir.6b00006
dc.identifier.urihttp://hdl.handle.net/10012/11804
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.subjectReduced Graphene Oxideen
dc.subjectNano-Grapheneen
dc.subjectMembraneen
dc.subjectSpectroscopyen
dc.subjectAdsorptionen
dc.subjectNanosheetsen
dc.subjectBacteriaen
dc.subjectDeliveryen
dc.subjectPlatformen
dc.subjectSensorsen
dc.titleLiposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetryen
dc.typeArticleen
dcterms.bibliographicCitationHuang, P.-J. J., Wang, F., & Liu, J. (2016). Liposome/Graphene Oxide Interaction Studied by Isothermal Titration Calorimetry. Langmuir, 32(10), 2458–2463. https://doi.org/10.1021/acs.langmuir.6b00006en
uws.contributor.affiliation1Faculty of Scienceen
uws.contributor.affiliation2Chemistryen
uws.contributor.affiliation3Waterloo Institute for Nanotechnology (WIN)en
uws.peerReviewStatusRevieweden
uws.scholarLevelFacultyen
uws.typeOfResourceTexten

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