The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern
| dc.contributor.author | Lin, Wei Ting David | |
| dc.contributor.author | Huang, Po-Jung Jimmy | |
| dc.contributor.author | Pautler, Rachel | |
| dc.contributor.author | Liu, Juewen | |
| dc.date.accessioned | 2017-02-27T20:36:50Z | |
| dc.date.available | 2017-02-27T20:36:50Z | |
| dc.date.issued | 2014-07-18 | |
| dc.description.abstract | Using sensitized Tb3+ luminescence spectroscopy as a tool, binding of 14 lanthanides to a lanthanide-dependent DNAzyme is studied, where the binding affinity is symmetric across the series and the tightest binding occurs with Nd3+ and Ho3+. This trend does not correlate with DNAzyme activity, suggesting that metal binding may not be the rate-limiting step of the DNAzyme catalysis. | en |
| dc.description.sponsorship | University of Waterloo || Canadian Foundation for Innovation || Natural Sciences and Engineering Research Council || Ontario Ministry of Research and Innovation || | en |
| dc.identifier.uri | http://dx.doi.org/10.1039/C4CC05551A | |
| dc.identifier.uri | http://hdl.handle.net/10012/11369 | |
| dc.language.iso | en | en |
| dc.publisher | Royal Society of Chemistry | en |
| dc.subject | DNA | en |
| dc.subject | DNAzymes | en |
| dc.subject | metal binding | en |
| dc.subject | Cleavage | en |
| dc.title | The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern | en |
| dc.type | Article | en |
| dcterms.bibliographicCitation | Lin, W. T. D., Huang, P.-J. J., Pautler, R., & Liu, J. (2014). The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern. Chem. Commun., 50(80), 11859–11862. https://doi.org/10.1039/C4CC05551A | en |
| uws.contributor.affiliation1 | Faculty of Science | en |
| uws.contributor.affiliation2 | Chemistry | en |
| uws.contributor.affiliation2 | Waterloo Institute for Nanotechnology (WIN) | en |
| uws.peerReviewStatus | Reviewed | en |
| uws.scholarLevel | Faculty | en |
| uws.typeOfResource | Text | en |