The group trend of lanthanides binding to DNA and DNAzymes with a complex but symmetric pattern
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Date
2014-07-18
Authors
Lin, Wei Ting David
Huang, Po-Jung Jimmy
Pautler, Rachel
Liu, Juewen
Journal Title
Journal ISSN
Volume Title
Publisher
Royal Society of Chemistry
Abstract
Using sensitized Tb3+ luminescence spectroscopy as a tool, binding of 14 lanthanides to a lanthanide-dependent DNAzyme is studied, where the binding affinity is symmetric across the series and the tightest binding occurs with Nd3+ and Ho3+. This trend does not correlate with DNAzyme activity, suggesting that metal binding may not be the rate-limiting step of the DNAzyme catalysis.
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Keywords
DNA, DNAzymes, metal binding, Cleavage