Browsing Optometry and Vision Science by Subject "contact lens"
Now showing items 1-9 of 9
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Antifungal ocular drug delivery via contact lenses using a novel in vitro eye model
(University of Waterloo, 2016-04-21)Purpose: The purpose of this thesis was to evaluate the potential of contact lenses (CLs) as an antifungal drug delivery device, and to develop an in vitro eye model to test thereof. Methods: The first three chapters ... -
Cellular changes at the lid margin
(University of Waterloo, 2017-11-28)PURPOSE: The hypothesis underlying this thesis is that CL wear, lid wiper epitheliopathy (LWE), and symptoms of dryness and discomfort may be manifest as cellular changes of the lid marginal epithelium, as a result of ... -
Development of an in vitro eye model to better represent in vivo physiological conditions
(University of Waterloo, 2021-06-23)Purpose The purpose of this thesis was to optimize a novel in vitro blink model, the OcuBlink, to best mimic the physiological characteristics of the human eye. By improving this in vitro model, the results from in vitro ... -
Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products
(University of Waterloo, 2009-04-27)The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty ... -
Fundamentals of Protein Adsorption at the Solid-Liquid Interface over Short Time Periods
(University of Waterloo, 2014-12-16)Purpose: To directly measure the quantity and degree of denaturation of biomaterial- adsorbed proteins over short time periods. Methods: Contact lenses were used as model biomaterials as they are widely used, readily ... -
In Vitro Release of Inflammatory Cytokines from Contact Lens Materials
(University of Waterloo, 2020-12-22)The upregulation of inflammatory mediators in the tear film during contact lens wear indicates that lens wear may induce an inflammatory response on the ocular surface. Previous research has investigated the relationship ... -
Lysozyme Deposition Studies on Silicone Hydrogel Contact Lens Materials
(University of Waterloo, 2005)Over 60 proteins have been detected in the tear film and among these lysozyme has attracted the greatest attention. Several techniques for elucidating the identity, quantity and conformation of lysozyme deposited on soft ... -
Protein Deposition and Bacterial Adhesion to Conventional and Silicone Hydrogel Contact Lens Materials
(University of Waterloo, 2009-04-27)Introduction Contact lenses suffer from the same problems of deposition that other biomaterials exhibit, being rapidly coated with a variety of proteins, lipids and mucins. The first event observed at the interface between ... -
Uptake and release of preservatives from soft contact lens materials
(University of Waterloo, 2022-01-13)Purpose: The purpose of this thesis was to examine the uptake and release of myristamidopropyl dimethylamine (MAPD) and polyhexamethylene biguanide (PHMB) from soft contact lens material using various in vitro models to ...