Browsing Chemistry by Author "Liu, Chang"
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Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry
Liu, Chang; Le Blanc, J. C. Yves; Schneider, Bradley B.; Shields, Jefry; Federico, James J.; Zhang, Hui; Stroh, Justin G.; Kauffman, Gregory W.; Kung, Daniel W.; Ieritano, Christian; Shepherdson, Evan; Verbuyst, Mitch; Melo, Luke; Hasan, Moaraj; Naser, Dalia; Janiszewski, John S.; Hopkins, W. Scott; Campbell, J. Larry (American Chemical Society, 2017-02-22)The microsolvated state of a molecule, represented by its interactions with only a small number of solvent molecules, can play a key role in determining the observable bulk properties of the molecule. This is especially ... -
Fast quantitation of opioid isomers in human plasma by differential mobility spectrometry/mass spectrometry via SPME/open-port probe sampling interface
Liu, Chang; Gómez-Ríos, Germán Augusto; Schneider, Bradley B.; Le Blanc, J. C. Yves; Reyes-Garcés, Nathaly; Arnold, Don W.; Covey, Thomas R.; Pawliszyn, Janusz (Elsevier, 2017-10-23)Mass spectrometry (MS) based quantitative approaches typically require a thorough sample clean-up and a decent chromatographic step in order to achieve needed figures of merit. However, in most cases, such processes are ... -
Open Port Probe Sampling Interface for the Direct Coupling of Biocompatible Solid-Phase Microextraction to Atmospheric Pressure Ionization Mass Spectrometry
Gomez-Rios, German Augusto; Liu, Chang; Tascon, Marcos; Reyes-Garcés, Nathaly; Arnold, Don W.; Covey, Thomas R.; Pawliszyn, Janusz (American Chemical Society, 2017-04-04)In recent years, the direct coupling of solid phase microextraction (SPME) and mass spectrometry (MS) has shown its great potential to improve limits of quantitation, accelerate analysis throughput, and diminish potential ... -
Using differential mobility spectrometry to measure ion solvation: An examination of the roles of solvents and ionic structures in separating quinoline-based drugs
Liu, Chang; Le Blanc, J. C. Yves; Shields, Jefry; Janiszewski, John S.; Ieritano, Christian; Ye, Gene F.; Hawes, Gillian F.; Hopkins, W. Scott; Campbell, J. Larry (Royal Society of Chemistry, 2015)Understanding the mechanisms and energetics of ion solvation is critical in many scientific areas. Here, we present a methodlogy for studying ion solvation using differential mobility spectrometry (DMS) coupled to mass ...