Browsing Science (Faculty of) by Author "Bols, Niels C."
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The characterization of γH2AX and p53 as biomarkers of genotoxic stress in a rainbow trout (Oncorhynchus mykiss) brain cell line
Hamilton, Mark Evan; Bols, Niels C.; Duncker, Bernard P. (Elsevier, 2018-06-01)Rainbow trout cell cultures were exposed to three genotoxicants and examined for effects on γH2AX and p53 levels by western blotting and on cell viability using the indicator dyes Alamar Blue (AB) for energy metabolism and ... -
CK-2 of rainbow trout (Oncorhynchus mykiss) has two differentially regulated alleles that encode a functional chemokine
Semple, Shawna L.; Eshaque, Shathi; Fujiki, Kazuhiro; Tang, Cynthia; Mitchell, Leslie; Bols, Niels C.; Dixon, Brian (Elsevier, 2018-04)Rainbow trout chemokine 2 (CK-2) is currently the only known CC chemokine to have a mucin stalk. Further analysis of the mucin stalk region revealed a second, related CC chemokine sequence, denoted here as CK-2.1. This ... -
Tapasin's protein interactions in the rainbow trout peptide-loading complex
Sever, Lital; Vo, Nguyen T. K.; Bols, Niels C.; Dixon, Brian (Elsevier, 2018-04-01)Major histocompatibility complex (MHC) class I receptors play a key role in the immune system by presenting non-self peptides to T cell lymphocytes. In humans, the assembly of the MHC class I with a peptide is mediated by ... -
VER-155008 induced Hsp70 proteins expression in fish cell cultures while impeding replication of two RNA viruses
Pham, Phuc Hoang; Sokeechand, Bibi S.H.; Hamilton, Mark Evan; Misk, Ehab; Jones, Ginny; Lee, Lucy E.J.; Lumsden, John S.; Bols, Niels C. (Elsevier, 2019-02-01)The heat-shock protein 70 (Hsp70) inhibitor, VER-155008 (VER), was explored as a potential antiviral agent for two RNA viruses important to fish aquaculture, viral hemorrhagic septicemia virus (VHSV) and infectious pancreatic ...