Browsing Health (Faculty of) by Supervisor "Quadrilatero, Joe"
Now showing items 1-8 of 8
-
Autophagy Regulates the NOTCH Signaling Pathway During Skeletal Muscle Cell Differentiation
(University of Waterloo, 2021-06-01)Research has indicated a crucial role for autophagy during skeletal muscle differentiation. More so, the inhibition of autophagy using 3MA (3-methyladenine), CQ (chloroquine), and shRNA against Atg7 has been shown to impair ... -
The Development of a Green Fluorescent Protein Reporter System for Apoptosis Repressor with Caspase Recruitment Domain Promoter Analysis
(University of Waterloo, 2017-01-31)Apoptosis is a form of controlled cell death that is important to tissue homeostasis. There are a variety of pro- and anti-apoptotic proteins that play an important role in the regulation of cell death. Apoptosis repressor ... -
Examining Autophagy and Mitophagy as Inducible Mechanisms of Cellular Remodelling
(University of Waterloo, 2017-11-20)Despite an explosion of knowledge regarding the molecular regulation of autophagy since its initial characterization in yeast in the 1990s (including the 2016 Nobel Prize in Physiology or Medicine for Dr Yoshinori Ohsumi), ... -
Examining the role of autophagy and mitophagy in regulating muscle differentiation
(University of Waterloo, 2019-05-22)Autophagy is a degradative process that is used to eliminate intracellular organelles and protein aggregates. Further, a selective form of autophagy, termed mitophagy, is used to specifically degrade mitochondria. ... -
Examining the role of caspase-2 in skeletal muscle cell differentiation
(University of Waterloo, 2016-09-26)Prior research has indicated a crucial role for apoptotic signaling in skeletal muscle cell differentiation. Although a number of caspases (-3, -8, -9) have been implicated in this process, few prior investigations have ... -
Examining the Role of DNM1L-Dependent Mitochondrial Fission and Mitophagy Receptors During Skeletal Muscle Differentiation
(University of Waterloo, 2020-07-27)Mitochondrial fission is necessary for the remodelling of existing mitochondria during skeletal muscle differentiation. When there is a need for muscle regeneration or repair, stem cell-like myoblasts exit the cell cycle, ... -
Interplay between Autophagy and Apoptosis During Skeletal Muscle Differentiation
(University of Waterloo, 2020-07-07)Our previous studies showed that autophagy regulates apoptosis and is required for proper skeletal muscle differentiation. Previously, we inhibited autophagy in C2C12 cells using 3MA (3-methyladenine) treatment or shRNA ... -
Investigating the Importance of RAB7 in C2C12 Myoblast Differentiation
(University of Waterloo, 2021-06-01)Prior research has shown that autophagy and mitophagy are intimately linked to skeletal muscle differentiation and myogenesis. Recent studies show that the RAB7 cycle is crucial in multiple stages of autophagy and mitophagy; ...