Browsing Theses by Subject "systems biology"
Now showing items 1-4 of 4
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Kinetic Modeling of Pyruvate Recycling Pathways in Pancreatic β-Cells.
(University of Waterloo, 2012-09-26)A variety of signaling mechanisms are employed to maintain healthy levels of glucose in the blood stream. The hormone insulin is one of the primary regulators of glucose homeostasis. Insulin, which activates glucose ... -
Optimal Experimental Design Applied to Models of Microbial Gene Regulation
(University of Waterloo, 2020-12-22)Microbial gene expression is a comparatively well understood process, but regulatory interactions between genes can give rise to complicated behaviours. Regulatory networks can exhibit strong context dependence, time-varying ... -
A Quantitative Model of the Initiation of DNA Replication in Saccharomyces cerevisiae
(University of Waterloo, 2012-05-01)A crucial step in eukaryotic cell proliferation is the initiation of DNA replication, a tightly regulated process mediated by a multitude of protein factors. In Saccharomyces cerevisiae, this occurs as a result of the ... -
Reducing the Emergence of the Gaps: Computation for Weak Emergence
(University of Waterloo, 2014-09-29)This thesis contributes to the growing literature surrounding the importance of weak emergence by showing it can account for more phenomena than originally conceived via the use of computational reduction. Weak emergence ...