Browsing Theses by Subject "monoclonal antibodies"
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Physiologically Based Pharmacokinetic Modeling of Monoclonal Antibodies in Children
(University of Waterloo, 2021-06-25)The following thesis chapters chronicle evolving efforts throughout 2016 – 2021 to support research toward improving the pediatric clinical pharmacology of monoclonal antibodies (mAbs). Translating the benefits of successful ... -
Production of a camelid antibody in CHO cells and its potential for the in vitro modification of its N-glycan using N- acetylglucosaminyltransferase III produced in insect cells
(University of Waterloo, 2015-01-07)Monoclonal antibodies have been extensively used for clinical diagnosis over the years. Beyond their ability to bind antigens, their ability to invoke or evade immune responses has also led to their use in therapeutic ...